C1QC and C1QB

Number of citations of the paper that reports this interaction (PMID 12960167)
39

Data Source:
HPRD (in vitro)

		C1QC	C1QB
Gene Name		complement component 1, q subcomponent, C chain	complement component 1, q subcomponent, B chain
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Collagen Trimer Complement Component C1 Complex Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function		Protein Binding Protein Homodimerization Activity
	Biological Process	Immune Response Complement Activation Complement Activation, Classical Pathway Negative Regulation Of Granulocyte Differentiation Innate Immune Response Negative Regulation Of Macrophage Differentiation	Complement Activation Complement Activation, Classical Pathway Innate Immune Response Inner Ear Development
Pathways		Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System	Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: C1QA C1QB FKBP2 PTX3	10 interactors: C1QA C1QC C1R DEFA1 EDA2R HRG IL32 MYOC PTX3 RELA
Entrez ID		714	713
HPRD ID		00395	00394
Ensembl ID		ENSG00000159189	ENSG00000173369
Uniprot IDs		P02747	P02746
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV	1PK6 2JG8 2JG9 2WNU 2WNV
Enriched GO Terms of Interacting Partners?		Innate Immune Response Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Negative Regulation Of Exo-alpha-sialidase Activity Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Immune Response Defense Response Leukocyte Mediated Immunity Adaptive Immune Response Response To Yeast Opsonization Negative Regulation Of Glycoprotein Metabolic Process Negative Regulation Of Viral Entry Into Host Cell Immune System Process Dopaminergic Neuron Differentiation Regulation Of Viral Entry Into Host Cell Sensory Organ Development Positive Regulation Of Immune Response Lens Morphogenesis In Camera-type Eye Interaction With Symbiont Lens Fiber Cell Differentiation Response To Fungus Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Immune Response Positive Regulation Of Phagocytosis Positive Regulation Of Immune System Process Regulation Of Nitric Oxide Biosynthetic Process Chaperone-mediated Protein Folding Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Stress Regulation Of Phagocytosis Negative Regulation Of Viral Process Protein Peptidyl-prolyl Isomerization Midbrain Development Positive Regulation Of Reactive Oxygen Species Metabolic Process Lens Development In Camera-type Eye Regulation Of Immune System Process Positive Regulation Of Endocytosis	Defense Response Immune Response Innate Immune Response Response To Fungus Humoral Immune Response Positive Regulation Of Immune Response Immune System Process Response To Stress Regulation Of Immune Response Positive Regulation Of Immune System Process Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Response To Stimulus Protein Activation Cascade Positive Regulation Of Focal Adhesion Assembly Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Positive Regulation Of Adherens Junction Organization Defense Response To Fungus Regulation Of Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Other Organism Leukocyte Mediated Immunity Adaptive Immune Response Response To Biotic Stimulus Regulation Of Focal Adhesion Assembly Positive Regulation Of Cell-matrix Adhesion Regulation Of Cell Junction Assembly ERBB2-ERBB3 Signaling Pathway Skeletal Muscle Hypertrophy Acetaldehyde Metabolic Process Cellular Response To Tumor Necrosis Factor ERBB2 Signaling Pathway Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Positive Regulation Of Schwann Cell Differentiation Heme Export Positive Regulation Of Blood Vessel Remodeling Negative Regulation Of Exo-alpha-sialidase Activity Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Schwann Cell Differentiation Negative Regulation Of Lamellipodium Assembly Response To Tumor Necrosis Factor Negative Regulation Of Endothelial Cell Chemotaxis Response To Cobalamin Defense Response To Virus Regulation Of Locomotion
Tagcloud ?		antioxidative atf3 atf4 atf5 axonal believe c1qa c1qb c57bl chac1 chop concurrently crush defense egr1 ganglion glaucoma hmox1 ocular onc optic retinal retinas rgc seq sham srxn1 transcriptome trb3	antioxidative atf3 atf4 atf5 axonal believe c1qa c1qc c57bl chac1 chop concurrently crush defense egr1 ganglion glaucoma hmox1 ocular onc optic retinal retinas rgc seq sham srxn1 transcriptome trb3
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		antioxidative atf3 atf4 atf5 axonal believe c1qa c1qb c1qc c57bl chac1 chop concurrently crush defense egr1 ganglion glaucoma hmox1 ocular onc optic retinal retinas rgc seq sham srxn1 transcriptome trb3