C1QC and PTX3

Number of citations of the paper that reports this interaction (PMID 12645945)
35

Data Source:
HPRD (in vitro)

		C1QC	PTX3
Gene Name		complement component 1, q subcomponent, C chain	pentraxin 3, long
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space
	Molecular Function		Complement Component C1q Binding (1->3)-beta-D-glucan Binding Virion Binding
	Biological Process	Immune Response Complement Activation Complement Activation, Classical Pathway Negative Regulation Of Granulocyte Differentiation Innate Immune Response Negative Regulation Of Macrophage Differentiation	Response To Yeast Inflammatory Response Opsonization Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Phagocytosis Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process
Pathways		Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: C1QA C1QB FKBP2 PTX3	5 interactors: C1QA C1QB C1QC CFH FGF2
Entrez ID		714	5806
HPRD ID		00395	03928
Ensembl ID		ENSG00000159189	ENSG00000163661
Uniprot IDs		P02747	P26022
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV
Enriched GO Terms of Interacting Partners?		Innate Immune Response Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Negative Regulation Of Exo-alpha-sialidase Activity Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Immune Response Defense Response Leukocyte Mediated Immunity Adaptive Immune Response Response To Yeast Opsonization Negative Regulation Of Glycoprotein Metabolic Process Negative Regulation Of Viral Entry Into Host Cell Immune System Process Dopaminergic Neuron Differentiation Regulation Of Viral Entry Into Host Cell Sensory Organ Development Positive Regulation Of Immune Response Lens Morphogenesis In Camera-type Eye Interaction With Symbiont Lens Fiber Cell Differentiation Response To Fungus Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Immune Response Positive Regulation Of Phagocytosis Positive Regulation Of Immune System Process Regulation Of Nitric Oxide Biosynthetic Process Chaperone-mediated Protein Folding Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Stress Regulation Of Phagocytosis Negative Regulation Of Viral Process Protein Peptidyl-prolyl Isomerization Midbrain Development Positive Regulation Of Reactive Oxygen Species Metabolic Process Lens Development In Camera-type Eye Regulation Of Immune System Process Positive Regulation Of Endocytosis	Complement Activation Protein Activation Cascade Humoral Immune Response Innate Immune Response Regulation Of Immune Response Immune Response Regulation Of Immune System Process Defense Response Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Immune Response Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Immune System Process Positive Regulation Of Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Response To Stress Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Cell Fate Specification Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Chondroblast Differentiation Inositol Phosphate Biosynthetic Process Regulation Of Satellite Cell Proliferation Negative Regulation Of Granulocyte Differentiation Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Macrophage Differentiation Complement Activation, Alternative Pathway Negative Regulation Of Fibroblast Migration Hyaluronan Catabolic Process Positive Regulation Of Cell Fate Commitment Regulation Of Sprouting Angiogenesis Regulation Of Cell Fate Specification Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Migration Involved In Sprouting Angiogenesis Response To Stimulus Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Chemotaxis Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Fibroblast Migration Blood Vessel Endothelial Cell Migration Regulation Of Complement Activation Regulation Of Cell Fate Commitment Negative Regulation Of Endothelial Cell Migration Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Heart Growth
Tagcloud ?		antioxidative atf3 atf4 atf5 axonal believe c1qa c1qb c57bl chac1 chop concurrently crush defense egr1 ganglion glaucoma hmox1 ocular onc optic retinal retinas rgc seq sham srxn1 transcriptome trb3	0288mg 072pg 161mg 161pg 1beta accumulating beta1 contributes crp daily diverse divided ds enrolled epilepsy frequent generalized hs inflammatory intermittent intractable motor organs pathomechanism pathophysiology pentraxin presenting seizures treat
Tagcloud (Difference) ?		antioxidative atf3 atf4 atf5 axonal believe c1qa c1qb c57bl chac1 chop concurrently crush defense egr1 ganglion glaucoma hmox1 ocular onc optic retinal retinas rgc seq sham srxn1 transcriptome trb3	0288mg 072pg 161mg 161pg 1beta accumulating beta1 contributes crp daily diverse divided ds enrolled epilepsy frequent generalized hs inflammatory intermittent intractable motor organs pathomechanism pathophysiology pentraxin presenting seizures treat
Tagcloud (Intersection) ?