C1QA and C1QC

Number of citations of the paper that reports this interaction (PMID 12960167)
39

Data Source:
HPRD (in vitro)

		C1QA	C1QC
Gene Name		complement component 1, q subcomponent, A chain	complement component 1, q subcomponent, C chain
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Trimer Complement Component C1 Complex Extracellular Vesicular Exosome	Extracellular Region Collagen Trimer Extracellular Space Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Binding
	Biological Process	Complement Activation Complement Activation, Classical Pathway Cell-cell Signaling Innate Immune Response	Immune Response Complement Activation Complement Activation, Classical Pathway Negative Regulation Of Granulocyte Differentiation Innate Immune Response Negative Regulation Of Macrophage Differentiation
Pathways		Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System	Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: APCS BAG6 C1QB C1QBP C1QC C1R C1S CD93 COL2A1 CR1 CRP CSPG4 DCN FN1 GNPNAT1 HIPK3 HRG PIAS2 PPP1CA PPP1CC PTX3 SGTA SLC25A47 UBQLN1 UBQLN2	4 interactors: C1QA C1QB FKBP2 PTX3
Entrez ID		712	714
HPRD ID		00393	00395
Ensembl ID		ENSG00000173372	ENSG00000159189
Uniprot IDs		P02745	P02747
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV	1PK6 2JG8 2JG9 2WNU 2WNV
Enriched GO Terms of Interacting Partners?		Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Defense Response Protein Metabolic Process Positive Regulation Of Immune Response Immune System Process Innate Immune Response Response To Stress Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Response Regulation Of Immune System Process Acute-phase Response Response To Stimulus Regulation Of Protein Metabolic Process Dermatan Sulfate Biosynthetic Process Opsonization Regulation Of Acute Inflammatory Response Acute Inflammatory Response Negative Regulation Of Signal Transduction Negative Regulation Of Glycoprotein Metabolic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Negative Regulation Of Signaling Extracellular Matrix Disassembly Negative Regulation Of Viral Entry Into Host Cell Proteoglycan Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Metabolic Process Regulation Of Viral Entry Into Host Cell Triglyceride Catabolic Process Chondroitin Sulfate Biosynthetic Process Entrainment Of Circadian Clock By Photoperiod Wound Healing Chondroitin Sulfate Proteoglycan Biosynthetic Process Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process	Innate Immune Response Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Protein Activation Cascade Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Negative Regulation Of Exo-alpha-sialidase Activity Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Humoral Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Immune Response Defense Response Leukocyte Mediated Immunity Adaptive Immune Response Response To Yeast Opsonization Negative Regulation Of Glycoprotein Metabolic Process Negative Regulation Of Viral Entry Into Host Cell Immune System Process Dopaminergic Neuron Differentiation Regulation Of Viral Entry Into Host Cell Sensory Organ Development Positive Regulation Of Immune Response Lens Morphogenesis In Camera-type Eye Interaction With Symbiont Lens Fiber Cell Differentiation Response To Fungus Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Immune Response Positive Regulation Of Phagocytosis Positive Regulation Of Immune System Process Regulation Of Nitric Oxide Biosynthetic Process Chaperone-mediated Protein Folding Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Stress Regulation Of Phagocytosis Negative Regulation Of Viral Process Protein Peptidyl-prolyl Isomerization Midbrain Development Positive Regulation Of Reactive Oxygen Species Metabolic Process Lens Development In Camera-type Eye Regulation Of Immune System Process Positive Regulation Of Endocytosis
Tagcloud ?		abeta affect allele alzheimer appps1 burden conferred copies copy deposition developing il1a influences intrem2 marked microglia microglial month morphological nos2 old pathology phagocytic plaque thought towards trem2 trends variant	antioxidative atf3 atf4 atf5 axonal believe c1qa c1qb c57bl chac1 chop concurrently crush defense egr1 ganglion glaucoma hmox1 ocular onc optic retinal retinas rgc seq sham srxn1 transcriptome trb3
Tagcloud (Difference) ?		abeta affect allele alzheimer appps1 burden conferred copies copy deposition developing il1a influences intrem2 marked microglia microglial month morphological nos2 old pathology phagocytic plaque thought towards trem2 trends variant	antioxidative atf3 atf4 atf5 axonal believe c1qb c57bl chac1 chop concurrently crush defense egr1 ganglion glaucoma hmox1 ocular onc optic retinal retinas rgc seq sham srxn1 transcriptome trb3
Tagcloud (Intersection) ?		c1qa