TMF1 and SMARCA4

Number of citations of the paper that reports this interaction (PMID 12044884)
6

Data Source:
HPRD (two hybrid, in vitro)

		TMF1	SMARCA4
Gene Name		TATA element modulatory factor 1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Endoplasmic Reticulum Golgi Apparatus	Nuclear Chromatin Heterochromatin Extracellular Space Nucleus Nucleoplasm Nuclear Euchromatin Perichromatin Fibrils Nucleolus Membrane SWI/SNF Complex Protein Complex NpBAF Complex NBAF Complex
	Molecular Function	DNA Binding Transcription Cofactor Activity Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Coactivator Activity P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Tat Protein Binding Nucleosomal DNA Binding Protein N-terminus Binding Androgen Receptor Binding DNA Polymerase Binding Lysine-acetylated Histone Binding
	Biological Process	Acrosome Assembly Positive Regulation Of Cytokine Production Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Spermatid Nucleus Differentiation Negative Regulation Of Gene Expression Sperm Motility Luteinizing Hormone Secretion Leydig Cell Differentiation Defense Response To Bacterium Negative Regulation Of Apoptotic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Testosterone Secretion	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Vasculogenesis Blastocyst Growth Blastocyst Hatching Liver Development Neural Retina Development Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Methylation-dependent Chromatin Silencing Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Glial Cell Fate Determination DNA Methylation On Cytosine Within A CG Sequence Stem Cell Maintenance Positive Regulation Of Wnt Signaling Pathway Extracellular Matrix Organization Keratinocyte Differentiation Negative Regulation Of Cell Growth Forebrain Development Hindbrain Development Embryonic Hindlimb Morphogenesis Aortic Smooth Muscle Cell Differentiation ATP-dependent Chromatin Remodeling Positive Regulation Of DNA Binding Positive Regulation By Host Of Viral Transcription Histone H3 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Organ Morphogenesis Epidermis Morphogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Definitive Erythrocyte Differentiation Heart Trabecula Formation Negative Regulation Of Androgen Receptor Signaling Pathway Lens Fiber Cell Development Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Chromatin modifying enzymes Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer RMTs methylate histone arginines
Drugs
Diseases
GWAS			Coronary heart disease ( 21347282)
Protein-Protein Interactions		8 interactors: AR FER GFI1B ITSN2 KAT2B NR3C1 RAB6A SMARCA4	73 interactors: ACTB ACTL6A AHR AR ARID1A ARID1B ARID2 BRCA1 BRWD1 CARM1 CBX5 CCNE1 CDK19 CDK8 CDKN2A CDX2 CEBPA CEBPB CHD4 CHMP5 CIITA CREB1 CTNNB1 DPF3 ESR1 ETS2 FANCA GATA1 GMNN H2AFX H3F3A HIST1H3A HIST1H4F HIST2H2BE HIST2H3C HSF1 HSF4 IKZF1 KLF1 MBD3 MDM2 MED17 MED6 MKL1 MPHOSPH6 MPP6 MYC MYOCD NR3C1 NR4A2 PABPN1 PAX6 PBRM1 PHB RAP1A RB1 RBL1 RBL2 RELB RFXAP SIN3A SIN3B SMARCB1 SMARCC1 SMARCE1 SS18 SS18L1 STAT2 STAT3 STK11 TMF1 TP53 ZMYND11
Entrez ID		7110	6597
HPRD ID		03081	04459
Ensembl ID		ENSG00000144747	ENSG00000127616
Uniprot IDs		P82094 Q6PII6	A7E2E1 B3KNW7 P51532 Q9HBD4
PDB IDs			2GRC 2H60 3UVD
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Chromatin Modification Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity DNA-templated Transcription, Initiation Chromatin Organization Regulation Of Gluconeogenesis Histone H3 Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Hormone Peptidyl-amino Acid Modification Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Integrin Biosynthetic Process Glucocorticoid Mediated Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Gland Development Steroid Hormone Mediated Signaling Pathway Regulation Of Glucose Metabolic Process Positive Regulation Of Transcription, DNA-templated Histone Acetylation Histone H3-K9 Acetylation Regulation Of Protein ADP-ribosylation Kit Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Diapedesis Regulation Of Transcription, DNA-templated Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of NF-kappaB Transcription Factor Activity Internal Protein Amino Acid Acetylation Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Hormone-mediated Signaling Pathway Protein Acetylation Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Integrin Biosynthetic Process Minus-end-directed Organelle Transport Along Microtubule Negative Regulation Of Glucocorticoid Mediated Signaling Pathway Peptidyl-cysteine Methylation N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Gene Expression Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Cellular Biosynthetic Process	Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromosome Organization Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Organelle Organization Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Chromatin Remodeling Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Cellular Process Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Anatomical Structure Development Developmental Process Chromatin Assembly Or Disassembly System Development Multicellular Organismal Development ATP-dependent Chromatin Remodeling
Tagcloud ?			abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating
Tagcloud (Difference) ?			abnormality arid1a coinactivation copyright fish frame harboring heterozygous infancy insights malignancies missense monoploid mrts pbrm1 protected remodeling reserved rhabdoid rights screened sense snf subunits swi trisomy truncating
Tagcloud (Intersection) ?