TJP1 and CTNNA1

Number of citations of the paper that reports this interaction (PMID 9214391)
127

Data Source:
HPRD (in vitro, in vivo)

		TJP1	CTNNA1
Gene Name		tight junction protein 1	catenin (cadherin-associated protein), alpha 1, 102kDa
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Adherens Junction Gap Junction Tight Junction Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cell Junction Apical Junction Complex Apical Part Of Cell Intercellular Canaliculus	Acrosomal Vesicle Cytosol Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Intercalated Disc Actin Cytoskeleton Catenin Complex Lamellipodium
	Molecular Function	Protein Binding Calmodulin Binding Protein C-terminus Binding Protein Domain Specific Binding	Structural Molecule Activity Protein Binding Beta-catenin Binding Vinculin Binding Poly(A) RNA Binding Gamma-catenin Binding Cadherin Binding Actin Filament Binding
	Biological Process	Blastocyst Formation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell-cell Junction Assembly Sensory Perception Of Sound Response To Lipopolysaccharide Hippo Signaling Response To Drug Negative Regulation Of Vascular Permeability Response To Ethanol Membrane Organization Response To Magnetism Cellular Response To Glucose Stimulus Establishment Of Endothelial Intestinal Barrier Cell-cell Signaling Involved In Cell-cell Junction Organization	Ovarian Follicle Development Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Neuroblast Proliferation Aging Male Gonad Development Gap Junction Assembly Axon Regeneration Cell Junction Assembly Adherens Junction Organization Cellular Protein Localization Odontogenesis Of Dentin-containing Tooth Muscle Cell Differentiation Apical Junction Assembly Response To Estrogen Cell-cell Junction Organization Positive Regulation Of Smoothened Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Muscle Cell Differentiation Protein Heterooligomerization Cellular Response To Indole-3-methanol Epithelial Cell-cell Adhesion Negative Regulation Of Cell Motility Negative Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Apoptotic cleavage of cell adhesion proteins c-src mediated regulation of Cx43 function and closure of gap junctions Apoptotic cleavage of cellular proteins Signaling by Hippo Gap junction trafficking and regulation Programmed Cell Death Apoptotic execution phase Regulation of gap junction activity	Cell junction organization Cell-cell junction organization CDO in myogenesis Myogenesis Signaling by VEGF Adherens junctions interactions VEGFR2 mediated vascular permeability VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943)
Protein-Protein Interactions		38 interactors: ACTA1 ACTN4 ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL MLLT4 PTPN14 TJP2 TJP3 TRPC4 UBN1 YBX3	27 interactors: ACTN1 AJUBA APC APP ARMC8 CA9 CDH1 CDH15 CDH2 CDH3 CDH5 CTBP1 CTNNB1 DLG1 FAM84B JUP MLLT4 PKD1 PSEN1 RNF219 SPTAN1 SPTBN1 SUMO1 TJP1 TJP2 VCL ZGPAT
Entrez ID		7082	1495
HPRD ID		03002	00285
Ensembl ID		ENSG00000104067	ENSG00000044115
Uniprot IDs		G3V1L9 Q07157 Q6MZU1	P35221
PDB IDs		2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ	1H6G 4EHP 4IGG
Enriched GO Terms of Interacting Partners?		Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Organization Cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cell Junction Assembly Cell-cell Junction Assembly Gap Junction Assembly Cell Development Establishment Of Endothelial Intestinal Barrier Anatomical Structure Development Cellular Component Assembly Developmental Process Epithelial Cell Development Apical Junction Assembly Establishment Of Endothelial Barrier Endothelium Development Neuron Projection Development Regulation Of Body Fluid Levels Response To Abiotic Stimulus Regulation Of Actin Filament-based Process Anatomical Structure Morphogenesis Tight Junction Assembly Transmembrane Transport Endothelial Cell Development Response To Organic Substance System Development Movement Of Cell Or Subcellular Component Neuron Development Cell Differentiation Atrial Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication Multicellular Organismal Development Locomotion Cell Communication Single Organismal Cell-cell Adhesion Epithelial Cell Differentiation Cell Morphogenesis Axon Development Endothelial Cell Differentiation Neuron Differentiation Cell-cell Signaling Involved In Cardiac Conduction Cell Projection Organization Positive Regulation Of Rap GTPase Activity Neurological System Process Establishment Of Skin Barrier Adherens Junction Organization Skin Development Neuron Projection Morphogenesis Cell-cell Signaling	Cell Junction Assembly Cell-cell Junction Organization Adherens Junction Organization Cell Adhesion Cellular Component Assembly Epithelium Development Developmental Process Anatomical Structure Development Cell-cell Junction Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Single Organismal Cell-cell Adhesion Execution Phase Of Apoptosis Adherens Junction Assembly Cell Differentiation Tissue Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cell Development Cellular Response To Indole-3-methanol Establishment Of Endothelial Barrier Apical Junction Assembly Anatomical Structure Morphogenesis Establishment Of Endothelial Intestinal Barrier Regulation Of Protein Complex Assembly Regulation Of Cellular Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Skin Development Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Endothelial Cell Development Tight Junction Assembly Positive Regulation Of Protein Metabolic Process Locomotion Endomembrane System Organization Neurogenesis Apoptotic Process Regulation Of Epithelial Cell Proliferation Regulation Of Signaling Cell Morphogenesis Involved In Differentiation Programmed Cell Death Morphogenesis Of An Epithelium Cell Death Death Cell-matrix Adhesion Positive Regulation Of Protein Complex Assembly Positive Regulation Of Cellular Protein Metabolic Process Endothelial Cell Differentiation Neuron Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Protein Localization
Tagcloud ?		abp androgen ar blots clonal clu constitutes fshr hampering immortalized immunocytochemistry inhbb investigations loose mediators microarrays posttranslational responsiveness rhox5 sc sertoli sox9 spermatogenesis spinlw1 st38c stabilization testosterone undergoes wt1	alphae alphat cardiomyocyte cardiomyocytes catenin catenins coactivator contractility cre delete divide dying gained heart hearts injured knockout lose perinatal proof rationale regulators replace shortly transgenes unable yap yes
Tagcloud (Difference) ?		abp androgen ar blots clonal clu constitutes fshr hampering immortalized immunocytochemistry inhbb investigations loose mediators microarrays posttranslational responsiveness rhox5 sc sertoli sox9 spermatogenesis spinlw1 st38c stabilization testosterone undergoes wt1	alphae alphat cardiomyocyte cardiomyocytes catenin catenins coactivator contractility cre delete divide dying gained heart hearts injured knockout lose perinatal proof rationale regulators replace shortly transgenes unable yap yes
Tagcloud (Intersection) ?