TG and HSPA5

Number of citations of the paper that reports this interaction (PMID 11294872)
4

Data Source:
HPRD (in vitro)

		TG	HSPA5
Gene Name		thyroglobulin	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleus Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Focal Adhesion COP9 Signalosome Cell Surface Membrane Integral Component Of Endoplasmic Reticulum Membrane Midbody Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Vesicular Exosome
	Molecular Function	Hormone Activity Carboxylic Ester Hydrolase Activity	Glycoprotein Binding Calcium Ion Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Ribosome Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding
	Biological Process	Signal Transduction Iodide Transport Thyroid Gland Development Regulation Of Myelination Thyroid Hormone Metabolic Process Hormone Biosynthetic Process	Platelet Degranulation ER Overload Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Blood Coagulation Cerebellum Structural Organization Cerebellar Purkinje Cell Layer Development Substantia Nigra Development Platelet Activation Positive Regulation Of Cell Migration ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Maintenance Of Protein Localization In Endoplasmic Reticulum Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Response To Antibiotic Cellular Response To Interleukin-4 Toxin Transport
Pathways			Platelet degranulation Antigen Presentation: Folding, assembly and peptide loading of class I MHC ATF6-alpha activates chaperone genes IRE1alpha activates chaperones Response to elevated platelet cytosolic Ca2+ Class I MHC mediated antigen processing & presentation Platelet activation, signaling and aggregation ATF6-alpha activates chaperones PERK regulates gene expression Unfolded Protein Response (UPR) Adaptive Immune System
Drugs			Antihemophilic Factor
Diseases
GWAS		Graves' disease ( 23612905) Temperament ( 22832960)
Protein-Protein Interactions		9 interactors: APCS ASGR1 CANX CTSD CTSL HSP90B1 HSPA5 LRP2 P4HB	53 interactors: A2M APC APOB BCAR1 CASP7 CPT1A DDX24 DNAJC1 DNAJC10 DPH1 DPYSL5 EIF2AK3 ERN1 ERP29 F8 FCHSD2 GRB2 GRIA1 HLA-C HSPBP1 HTR3A ID2 IGHM KRT14 KRT18 KRT8 LCT LDLR METTL21A MTNR1A MTNR1B NDRG1 PAWR PCSK7 PRNP PSME3 RPN1 SEC61A1 SH3BP4 SIL1 SREBF2 STMN1 SUMO4 TCERG1 TG TMEM132A TMEM62 TRA TSHR UBQLN4 VHL VWF YWHAB
Entrez ID		7038	3309
HPRD ID		01782	00682
Ensembl ID		ENSG00000042832	ENSG00000044574
Uniprot IDs		P01266	P11021
PDB IDs			3IUC 3LDL 3LDN 3LDO 3LDP
Enriched GO Terms of Interacting Partners?		Protein Folding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Receptor-mediated Endocytosis Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Response To Endoplasmic Reticulum Stress Endocytosis Protein Metabolic Process Antigen Processing And Presentation Of Peptide Antigen Vesicle-mediated Transport ER-associated Ubiquitin-dependent Protein Catabolic Process Proteolysis Antigen Processing And Presentation Cellular Protein Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Collagen Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Protein Folding In Endoplasmic Reticulum Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Extracellular Matrix Disassembly Immune System Process Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Toll-like Receptor Signaling Pathway Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Actin Rod Assembly Cerebellum Structural Organization Negative Regulation Of Exo-alpha-sialidase Activity Macrophage Apoptotic Process Cellular Response To Topologically Incorrect Protein Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Pattern Recognition Receptor Signaling Pathway Response To Unfolded Protein Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein Catabolic Process Sequestering Of Calcium Ion Positive Regulation Of Innate Immune Response Negative Regulation Of Monocyte Differentiation Cellular Response To Extracellular Stimulus Innate Immune Response Myeloid Cell Apoptotic Process Catabolic Process	Response To Stimulus Cellular Response To Stimulus Apoptotic Signaling Pathway Response To Stress Blood Coagulation, Intrinsic Pathway Cell Activation Signal Transduction Apoptotic Process Positive Regulation Of Metabolic Process Programmed Cell Death Signaling Positive Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway Cell Death Death Cell Communication Platelet Activation Regulation Of Proteolysis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Body Fluid Levels Negative Regulation Of Cellular Protein Metabolic Process Blood Coagulation Negative Regulation Of Cellular Metabolic Process Protein Oligomerization Hemostasis Response To External Stimulus Cellular Response To Organic Substance Protein Folding Regulation Of Lipid Metabolic Process Response To Organic Substance Response To Inorganic Substance Negative Regulation Of Protein Metabolic Process Platelet Degranulation Lipoprotein Catabolic Process Regulation Of Apoptotic Process Regulation Of Cholesterol Homeostasis Hepatocyte Apoptotic Process Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cholesterol Storage Negative Regulation Of T Cell Receptor Signaling Pathway Axonogenesis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Viral Process Cellular Response To Stress Cell Development Anatomical Structure Morphogenesis
Tagcloud ?		amplify aspiration checked cytological cytology deiodinase di diagnostically dii dilutions fine fnab fnabs ftc ie iodide iodothyronine isolation mentioned needle nis obtaining preparing rendered routinely smears suspicious symporter thyroglobulin thyroid	17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 lies linkage loci map mmu2 nf1 occupy painting places probable rxra syntenic telomeric thirds
Tagcloud (Difference) ?		amplify aspiration checked cytological cytology deiodinase di diagnostically dii dilutions fine fnab fnabs ftc ie iodide iodothyronine isolation mentioned needle nis obtaining preparing rendered routinely smears suspicious symporter thyroglobulin thyroid	17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 lies linkage loci map mmu2 nf1 occupy painting places probable rxra syntenic telomeric thirds
Tagcloud (Intersection) ?