SP100 and L3MBTL3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SP100	L3MBTL3
Gene Name		SP100 nuclear antigen	l(3)mbt-like 3 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm PML Body Mre11 Complex Nuclear Periphery	Nucleus
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Kinase Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Chromo Shadow Domain Binding	Molecular_function
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Telomere Maintenance Chromatin Remodeling Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Endothelial Cell Migration Viral Process Cytokine-mediated Signaling Pathway Response To Retinoic Acid Negative Regulation Of Viral Transcription Response To Cytokine Response To Type I Interferon Response To Interferon-gamma Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Protein Export From Nucleus Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cellular Component Movement Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Fas Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Chromatin Modification Macrophage Differentiation Granulocyte Differentiation Erythrocyte Maturation
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			Height ( 20881960 23563607 18391951)
Protein-Protein Interactions		38 interactors: ACTN2 AMOTL2 ARID3A CASP8AP2 CBX1 CBX3 CBX5 CREM DNMT3A DYRK2 ETS1 GIPC2 HIPK2 L3MBTL3 LZTR1 MX1 MYB NIPBL PHC1 PML RANBP2 RBM39 RTP5 SAE1 SENP1 SNIP1 SUMO1 SUMO2 SUMO3 TERF1 TERF2 TERF2IP TRAF3IP3 TRIM29 UBA2 UBE2I USPL1 ZC2HC1A	26 interactors: ASB6 BANP BYSL KDM1A LRRK2 LSM4 LZTR1 MAPK3 MAPK9 MORF4L1 MORF4L2 NGB OAZ3 PDE6G PHC2 PIK3R3 PLEKHF1 PLEKHF2 POLR2L PRKAA1 PRKAA2 SNRPB SP100 SUMO1P1 THRA TTC19
Entrez ID		6672	84456
HPRD ID		06844	11222
Ensembl ID		ENSG00000067066	ENSG00000198945
Uniprot IDs		E7EUA7 P23497 Q6ZMK3	Q96JM7
PDB IDs		1H5P	1WJQ 1WJS 3UT1 4FL6 4L59
Enriched GO Terms of Interacting Partners?		Protein Sumoylation PML Body Organization Regulation Of Metabolic Process Peptidyl-lysine Modification Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Telomere Maintenance Post-translational Protein Modification Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Nucleus Organization Regulation Of Transcription, DNA-templated Peptidyl-amino Acid Modification Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process Regulation Of Cellular Process SMT3-dependent Protein Catabolic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Organelle Organization Positive Regulation Of Proteolysis RNA-dependent DNA Replication Positive Regulation Of Cellular Metabolic Process Telomeric Loop Formation Age-dependent Telomere Shortening Negative Regulation Of Chromosome Organization Chromosome Organization Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Protein Desumoylation Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomere Lengthening Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Telomere Capping Chromatin Modification Positive Regulation Of Cellular Protein Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase	Positive Regulation Of Autophagy Chromatin Modification Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Binding RNA Metabolic Process Regulation Of Autophagy Chromatin Organization Transcription, DNA-templated Positive Regulation Of Metabolic Process RNA Biosynthetic Process Regulation Of Lipid Metabolic Process Cellular Response To Stress Activation Of MAPK Activity Insulin Receptor Signaling Pathway Negative Regulation Of Protein Binding Negative Regulation Of Transport Chromosome Organization Gene Expression Positive Regulation Of MAP Kinase Activity Cellular Response To Insulin Stimulus Regulation Of Energy Homeostasis Regulation Of Apoptotic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Intracellular Protein Transport Fatty Acid Homeostasis Positive Regulation Of Gene Expression Cellular Response To Organonitrogen Compound Regulation Of Cell Death Cellular Nitrogen Compound Metabolic Process Regulation Of Binding Regulation Of Circadian Rhythm Organelle Organization Response To Organonitrogen Compound Regulation Of Metabolic Process Activation Of Protein Kinase Activity Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Nucleobase-containing Compound Metabolic Process Regulation Of MAP Kinase Activity Response To Insulin Negative Regulation Of Intracellular Transport Histone-serine Phosphorylation Regulation Of Signal Transduction Peptidyl-serine Phosphorylation Regulation Of Intracellular Signal Transduction Cellular Response To Peptide Hormone Stimulus Cellular Response To Hormone Stimulus Response To Stress Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Glucose Starvation
Tagcloud ?		aml1 autoregulatory cdnas cofactor deaf deformed deoxyribonuclease displaced dnase fetus germ immunocytochemistry inductions monkey mtg8 nonhomeodomain nudr oncoprotein prodynorphin proenkephalin rares shifts similarities testicular thymidine transfections transferable ttcg ttcgggnntttccgg
Tagcloud (Difference) ?		aml1 autoregulatory cdnas cofactor deaf deformed deoxyribonuclease displaced dnase fetus germ immunocytochemistry inductions monkey mtg8 nonhomeodomain nudr oncoprotein prodynorphin proenkephalin rares shifts similarities testicular thymidine transfections transferable ttcg ttcgggnntttccgg
Tagcloud (Intersection) ?