SP100 and RANBP2

Number of citations of the paper that reports this interaction (PMID 15608651)
38

Data Source:
BioGRID (enzymatic study)

		SP100	RANBP2
Gene Name		SP100 nuclear antigen	RAN binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm PML Body Mre11 Complex Nuclear Periphery	Nuclear Pore Mitochondrion Cytosol Membrane Nuclear Membrane Nuclear Inclusion Body Nuclear Pore Nuclear Basket
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Kinase Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Chromo Shadow Domain Binding	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Zinc Ion Binding Ran GTPase Binding Ligase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Telomere Maintenance Chromatin Remodeling Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Endothelial Cell Migration Viral Process Cytokine-mediated Signaling Pathway Response To Retinoic Acid Negative Regulation Of Viral Transcription Response To Cytokine Response To Type I Interferon Response To Interferon-gamma Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Protein Export From Nucleus Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cellular Component Movement Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Fas Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription	Mitotic Cell Cycle Protein Peptidyl-prolyl Isomerization Carbohydrate Metabolic Process Protein Folding Protein Import Into Nucleus Mitotic Nuclear Envelope Disassembly Hexose Transport Pathogenesis Gene Expression Regulation Of Glucose Transport Glucose Transport Viral Process Protein Sumoylation Viral Life Cycle Viral Transcription Cytokine-mediated Signaling Pathway Negative Regulation Of Glucokinase Activity Small Molecule Metabolic Process MRNA Transport Transmembrane Transport Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system	Mitotic Prometaphase Separation of Sister Chromatids Mitotic Prophase HIV Infection Nuclear import of Rev protein Regulatory RNA pathways Rev-mediated nuclear export of HIV RNA Nuclear Envelope Breakdown Mitotic Anaphase SLC-mediated transmembrane transport M Phase Influenza Life Cycle HIV Life Cycle Influenza Viral RNA Transcription and Replication Rev-mediated nuclear export of HIV RNA Myoclonic epilepsy of Lafora Glycogen storage diseases Transcriptional regulation by small RNAs Vpr-mediated nuclear import of PICs ISG15 antiviral mechanism Interferon Signaling Host Interactions of HIV factors Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear Pore Complex (NPC) Disassembly Cytokine Signaling in Immune system Interactions of Vpr with host cellular proteins Interactions of Rev with host cellular proteins Influenza Infection Hexose transport Cell Cycle, Mitotic Late Phase of HIV Life Cycle Antiviral mechanism by IFN-stimulated genes Resolution of Sister Chromatid Cohesion Viral Messenger RNA Synthesis Metabolism of carbohydrates Glucose transport Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: ACTN2 AMOTL2 ARID3A CASP8AP2 CBX1 CBX3 CBX5 CREM DNMT3A DYRK2 ETS1 GIPC2 HIPK2 L3MBTL3 LZTR1 MX1 MYB NIPBL PHC1 PML RANBP2 RBM39 RTP5 SAE1 SENP1 SNIP1 SUMO1 SUMO2 SUMO3 TERF1 TERF2 TERF2IP TRAF3IP3 TRIM29 UBA2 UBE2I USPL1 ZC2HC1A	34 interactors: AKAP13 ARID4B CALM1 CDCA8 CUL1 FHOD1 HDAC4 IFT140 IPO5 KPNA1 KPNA2 KPNB1 LRPAP1 MDM2 NUP62 NXF1 OPN1LW OPN1MW PARK2 RAN RANGAP1 SAE1 SENP1 SP100 SUMO1 TAF1 TNPO1 TOP2B TP53 UBA2 UBE2I UBTD1 XPO1 XPOT
Entrez ID		6672	5903
HPRD ID		06844	03111
Ensembl ID		ENSG00000067066	ENSG00000153201
Uniprot IDs		E7EUA7 P23497 Q6ZMK3	P49792
PDB IDs		1H5P	1RRP 1XKE 1Z5S 3UIN 3UIO 3UIP 4GA0 4I9Y 4L6E 4LQW
Enriched GO Terms of Interacting Partners?		Protein Sumoylation PML Body Organization Regulation Of Metabolic Process Peptidyl-lysine Modification Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Telomere Maintenance Post-translational Protein Modification Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Nucleus Organization Regulation Of Transcription, DNA-templated Peptidyl-amino Acid Modification Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process Regulation Of Cellular Process SMT3-dependent Protein Catabolic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Organelle Organization Positive Regulation Of Proteolysis RNA-dependent DNA Replication Positive Regulation Of Cellular Metabolic Process Telomeric Loop Formation Age-dependent Telomere Shortening Negative Regulation Of Chromosome Organization Chromosome Organization Telomere Maintenance Via Telomere Shortening Protection From Non-homologous End Joining At Telomere Protein Desumoylation Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomere Lengthening Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Telomere Capping Chromatin Modification Positive Regulation Of Cellular Protein Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase	Viral Process Nucleocytoplasmic Transport Nuclear Transport Protein Localization To Nucleus Protein Localization To Organelle Cytoplasmic Transport Peptidyl-lysine Modification Protein Import Into Nucleus Nuclear Import Cellular Localization Protein Sumoylation Protein Import NLS-bearing Protein Import Into Nucleus Positive Regulation Of Metabolic Process Cellular Protein Localization Establishment Of Localization In Cell Intracellular Transport Mitotic Cell Cycle Regulation Of Protein Export From Nucleus Intracellular Transport Of Virus Protein Localization Regulation Of Intracellular Transport Regulation Of Nucleocytoplasmic Transport Establishment Of Protein Localization To Organelle Nuclear Export Cellular Response To Organic Substance Regulation Of Protein Localization Regulation Of Protein Catabolic Process Cell Cycle Regulation Of Intracellular Protein Transport Protein Targeting Protein Modification By Small Protein Conjugation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Binding Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Establishment Of Protein Localization SMT3-dependent Protein Catabolic Process Intracellular Protein Transport Positive Regulation Of Cellular Protein Catabolic Process Response To Organic Substance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Establishment Of Protein Localization Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Positive Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Gene Expression Peptidyl-amino Acid Modification Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		aml1 autoregulatory cdnas cofactor deaf deformed deoxyribonuclease displaced dnase fetus germ immunocytochemistry inductions monkey mtg8 nonhomeodomain nudr oncoprotein prodynorphin proenkephalin rares shifts similarities testicular thymidine transfections transferable ttcg ttcgggnntttccgg	adar colorectal contain dcaf12l2 exomes glt1d1 hot instability itga7 map1b microsatellite mrgprx4 oncogenes personalized profiling psrc1 respective rps6kl1 sequenced sncaip spot spots tceal6 tubb6 validated validation vegfb wbp5 zbtb2
Tagcloud (Difference) ?		aml1 autoregulatory cdnas cofactor deaf deformed deoxyribonuclease displaced dnase fetus germ immunocytochemistry inductions monkey mtg8 nonhomeodomain nudr oncoprotein prodynorphin proenkephalin rares shifts similarities testicular thymidine transfections transferable ttcg ttcgggnntttccgg	adar colorectal contain dcaf12l2 exomes glt1d1 hot instability itga7 map1b microsatellite mrgprx4 oncogenes personalized profiling psrc1 respective rps6kl1 sequenced sncaip spot spots tceal6 tubb6 validated validation vegfb wbp5 zbtb2
Tagcloud (Intersection) ?