BOK and BCL2A1

Number of citations of the paper that reports this interaction (PMID 9356461)
41

Data Source:
HPRD (two hybrid)

		BOK	BCL2A1
Gene Name		BCL2-related ovarian killer	BCL2-related protein A1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane	Mitochondrial Outer Membrane
	Molecular Function	Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH Domain Binding	Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH Domain Binding
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Brain Development Cell Proliferation Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Oligodendrocyte Differentiation Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Execution Phase Of Apoptosis	Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Brain structure ( 20171287) Prostate cancer ( 23535732)
Protein-Protein Interactions		3 interactors: BCL2A1 MCL1 NOA1	15 interactors: APP BAD BAK1 BAX BBC3 BCL2L11 BID BIK BMF BOK FAM9B GRB2 HRK NR4A1 PMAIP1
Entrez ID		666	597
HPRD ID		05657	03034
Ensembl ID		ENSG00000176720	ENSG00000140379
Uniprot IDs		Q9UMX3	Q16548
PDB IDs			2VM6 3I1H 3MQP
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Death Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Mitochondrion Organization Positive Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Intracellular Signal Transduction Regulation Of Cellular Respiration Negative Regulation Of Anoikis Regulation Of Anoikis Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To DNA Damage Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Oxidative Stress Cell Fate Determination Negative Regulation Of Signaling Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Protein Transmembrane Transport Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Neuron Apoptotic Process Apoptotic Mitochondrial Changes Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Neuron Death Mitochondrial Translation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Intracellular Signal Transduction Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Ribosome Biogenesis Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway	Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Mitochondrion Organization Positive Regulation Of Protein Oligomerization Regulation Of Mitochondrion Organization Regulation Of Protein Oligomerization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Protein Homooligomerization Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Apoptotic Mitochondrial Changes Positive Regulation Of Organelle Organization Apoptotic Process Positive Regulation Of Peptidase Activity Programmed Cell Death Cell Death Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Protein Complex Assembly Activation Of Cysteine-type Endopeptidase Activity Intrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Zymogen Activation Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Peptidase Activity Positive Regulation Of Endopeptidase Activity Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Proteolysis Regulation Of Membrane Permeability Positive Regulation Of Cellular Component Biogenesis Regulation Of Protein Complex Assembly Apoptotic Signaling Pathway Regulation Of Organelle Organization Regulation Of Apoptotic Process Regulation Of Proteolysis Protein Processing Positive Regulation Of Intracellular Transport Regulation Of Cell Death Mitochondrial Membrane Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Tagcloud ?		acridine ameliorated arrested atf3 bak1 bax bromide bromodeoxyuridine cdk1 cullin cytoprotective defect diablo downregulated embryo embryos ethidium evaluating expressions morphologic mumol noxa nuclei orange pifithrin reproductive resveratrol smac toxin	aims apoptotic bax brdu cdk1 cdk4 changed cyclind1 cytometer explored facscan immunoblotting incorporation insulin manners obatoclax oncogene osteoblasts osteoclast poorly precursors promoted promotes remarkably suppressing treating ultimately
Tagcloud (Difference) ?		acridine ameliorated arrested atf3 bak1 bromide bromodeoxyuridine cullin cytoprotective defect diablo downregulated embryo embryos ethidium evaluating expressions morphologic mumol noxa nuclei orange pifithrin reproductive resveratrol smac toxin	aims apoptotic brdu cdk4 changed cyclind1 cytometer explored facscan immunoblotting incorporation insulin manners obatoclax oncogene osteoblasts osteoclast poorly precursors promoted promotes remarkably suppressing treating ultimately
Tagcloud (Intersection) ?		bax cdk1