BCL2A1 and BCL2L11

Number of citations of the paper that reports this interaction (PMID 16697956)
236

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		BCL2A1	BCL2L11
Gene Name		BCL2-related protein A1	BCL2-like 11 (apoptosis facilitator)
Image
Gene Ontology Annotations	Cellular Component	Mitochondrial Outer Membrane	Mitochondrial Outer Membrane Cytosol Microtubule Endomembrane System Extrinsic Component Of Membrane BIM-BCL-xl Complex BIM-BCL-2 Complex
	Molecular Function	Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH Domain Binding	Protein Binding Microtubule Binding
	Biological Process	Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	In Utero Embryonic Development B Cell Homeostasis B Cell Apoptotic Process Kidney Development Myeloid Cell Homeostasis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell-matrix Adhesion Spermatogenesis Brain Development Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mammary Gland Development Positive Regulation Of Protein Homooligomerization Response To Endoplasmic Reticulum Stress Tube Formation Odontogenesis Of Dentin-containing Tooth T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ear Development Positive Regulation Of Cell Cycle Regulation Of Organ Growth Neurotrophin TRK Receptor Signaling Pathway Developmental Pigmentation Regulation Of Developmental Pigmentation Spleen Development Thymus Development Post-embryonic Organ Morphogenesis Positive Regulation Of Apoptotic Process By Virus Cellular Process Regulating Host Cell Cycle In Response To Virus Thymocyte Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Activation of BIM and translocation to mitochondria NRAGE signals death through JNK Programmed Cell Death Activation of BH3-only proteins p75 NTR receptor-mediated signalling BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS			Chronic lymphocytic leukemia ( 18758461) Dehydroepiandrosterone sulphate levels ( 21533175) Primary sclerosing cholangitis ( 21151127)
Protein-Protein Interactions		15 interactors: APP BAD BAK1 BAX BBC3 BCL2L11 BID BIK BMF BOK FAM9B GRB2 HRK NR4A1 PMAIP1	26 interactors: AKT1 APP ATP6V1G1 AURKB BCL2 BCL2A1 BCL2L1 BCL2L2 BTK DYNLL1 DYNLL2 FEM1C FGL1 GNB2L1 GTF2I MAGEA11 MAPK10 MAPK8 MAPK9 MCL1 MEX3D RIOK3 SMARCB1 TRIM2 VDAC1 YWHAB
Entrez ID		597	10018
HPRD ID		03034	04828
Ensembl ID		ENSG00000140379	ENSG00000153094
Uniprot IDs		Q16548	O43521
PDB IDs		2VM6 3I1H 3MQP	1F95 2K7W 2NL9 2V6Q 2VM6 2WH6 2YQ6 3D7V 3FDL 3IO8 3IO9 3KJ0 3KJ1 3KJ2 4B4S
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Mitochondrion Organization Positive Regulation Of Protein Oligomerization Regulation Of Mitochondrion Organization Regulation Of Protein Oligomerization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Protein Homooligomerization Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Apoptotic Mitochondrial Changes Positive Regulation Of Organelle Organization Apoptotic Process Positive Regulation Of Peptidase Activity Programmed Cell Death Cell Death Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Protein Complex Assembly Activation Of Cysteine-type Endopeptidase Activity Intrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Zymogen Activation Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Peptidase Activity Positive Regulation Of Endopeptidase Activity Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Proteolysis Regulation Of Membrane Permeability Positive Regulation Of Cellular Component Biogenesis Regulation Of Protein Complex Assembly Apoptotic Signaling Pathway Regulation Of Organelle Organization Regulation Of Apoptotic Process Regulation Of Proteolysis Protein Processing Positive Regulation Of Intracellular Transport Regulation Of Cell Death Mitochondrial Membrane Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Programmed Cell Death Cell Death Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand JUN Phosphorylation Intracellular Signal Transduction Apoptotic Mitochondrial Changes Regulation Of Signal Transduction Response To Radiation Positive Regulation Of Signal Transduction Response To Light Stimulus Regulation Of Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Stress Positive Regulation Of Intracellular Transport Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Response To UV Regulation Of Establishment Of Protein Localization Fc Receptor Signaling Pathway Negative Regulation Of Cell Death Immune Response-regulating Signaling Pathway Regulation Of Neuron Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Defense Response Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Anoikis
Tagcloud ?		aims apoptotic bax brdu cdk1 cdk4 changed cyclind1 cytometer explored facscan immunoblotting incorporation insulin manners obatoclax oncogene osteoblasts osteoclast poorly precursors promoted promotes remarkably suppressing treating ultimately	akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Difference) ?		aims apoptotic bax brdu cdk1 cdk4 changed cyclind1 cytometer explored facscan immunoblotting incorporation insulin manners obatoclax oncogene osteoblasts osteoclast poorly precursors promoted promotes remarkably suppressing treating ultimately	akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Intersection) ?