NEDD4L and WNK4

  • Number of citations of the paper that reports this interaction (PMID 20525693)
  • 13
  • Data Source:
  • BioGRID (enzymatic study)

NEDD4L

WNK4

Gene Name neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase WNK lysine deficient protein kinase 4
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Insomnia (caffeine-induced) ( 22754043)
  • Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)
  • Response to amphetamines ( 22952603)
Protein-Protein Interactions 126 interactors: AATF ABL1 ABL2 ACVR1B ACY3 ADAP2 AICDA AKT3 APEX2 ARHGDIA AURKC BBX BMPR1A BRAF C7orf50 CACNB1 CAMK1D CDC34 CDK3 CDK5 CLIC2 CUEDC1 CYBRD1 CYP26B1 DAPK3 DAZAP2 DDX54 DECR2 DMTN DYRK3 EFEMP2 FGF12 FKBP3 GORAB H1F0 HAX1 HGS IFRD2 IKBKB KCNAB1 KCNAB2 KCNAB3 KCNB1 KIF3B KIFC3 LAPTM5 MAGEB1 MAP2 MAP3K2 MAP3K3 MAP3K5 MAPKAPK3 MARK2 MERTK MINK1 MOB3A MRPL19 NDFIP2 NHP2 NR3C1 NSRP1 NTRK1 NUDT16L1 PBX1 PRKX PRR16 PRRG1 PSMD4 RANBP10 RASL10B RASL11B RNF11 RNF7 ROBO3 RPL30 RPS6KB2 SCAMP3 SCD SCN5A SCNN1A SCNN1B SCNN1G SENP2 SERPINF1 SGK1 SGK2 SIVA1 SLC7A7 SMAD2 SMAD3 SMAD7 SNCA SPAG8 SRMS STAC STK40 TAF1B TARBP2 TBC1D7 TCEAL2 TGFB1I1 TMA16 TMEM55A TRIM41 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2J2 UBE2K UBE2L3 UBE2N VDAC2 WIBG WNK1 WNK4 YWHAG YWHAZ YY1 ZADH2 ZAK ZC3HAV1L ZDHHC3 11 interactors: AKT1 BCL6 CLDN1 CLDN2 CLDN3 CLDN4 KLHL2 KLHL3 NEDD4L SLC12A3 STK39
Entrez ID 23327 65266
HPRD ID 05903 03505
Ensembl ID ENSG00000049759 ENSG00000126562
Uniprot IDs B7Z2P9 B7Z6K0 F5H602 Q96PU5 B0LPI0 Q96J92
PDB IDs 2LAJ 2LB2 2LTY 2NSQ 2ONI 3JVZ 3JW0 2V3S
Enriched GO Terms of Interacting Partners?
Tagcloud ?
2cl  antihypertensive  cotransporter  defective  demonstrating  emerging  enac  exchanger  highlight  hypertension  interactor  interesting  liddle  ligase  makes  na  ncc  nephron  nhe3  nkcc2  originally  progress  salt  sensitive  thiazide  transporters  ubiquitin  ubiquitylates 
aii  cotransporter  cul3  cullin  depletion  directing  hyperkalemia  hypertension  impair  inverse  kelch  klhl3  ligase  maximize  maximized  missense  nacl  obligatory  obscure  phenocopy  physiologic  posited  prevents  reabsorption  s433  salt  volume  wnk1  wnks 
Tagcloud (Difference) ?
2cl  antihypertensive  defective  demonstrating  emerging  enac  exchanger  highlight  interactor  interesting  liddle  makes  na  ncc  nephron  nhe3  nkcc2  originally  progress  sensitive  thiazide  transporters  ubiquitin  ubiquitylates 
aii  cul3  cullin  depletion  directing  hyperkalemia  impair  inverse  kelch  klhl3  maximize  maximized  missense  nacl  obligatory  obscure  phenocopy  physiologic  posited  prevents  reabsorption  s433  volume  wnk1  wnks 
Tagcloud (Intersection) ?
cotransporter  hypertension  ligase  salt