SLC6A2 and STX1A

Number of citations of the paper that reports this interaction (PMID 12629174)
35

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SLC6A2	STX1A
Gene Name		solute carrier family 6 (neurotransmitter transporter), member 2	syntaxin 1A (brain)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Neuron Projection Membrane Raft	Extracellular Region Cytosol Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane Cell Junction Secretory Granule Synaptic Vesicle Membrane SNARE Complex Actomyosin Neuron Projection Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex
	Molecular Function	Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Alpha-tubulin Binding Beta-tubulin Binding	SNARE Binding Glycoprotein Binding SNAP Receptor Activity Protein Binding Myosin Binding Calcium Channel Inhibitor Activity Chloride Channel Inhibitor Activity Kinase Binding Protein Domain Specific Binding Protein Binding, Bridging Myosin Head/neck Binding ATP-dependent Protein Binding Protein Heterodimerization Activity Protein N-terminus Binding Calcium-dependent Protein Binding
	Biological Process	Transport Neurotransmitter Transport Synaptic Transmission Monoamine Transport Norepinephrine Transport Response To Drug Response To Pain Transmembrane Transport	Positive Regulation Of Neurotransmitter Secretion Energy Reserve Metabolic Process Intracellular Protein Transport Synaptic Transmission Neurotransmitter Secretion Pathogenesis Response To Gravity Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Docking Calcium Ion-dependent Exocytosis Synaptic Vesicle Fusion To Presynaptic Membrane Secretion By Cell Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Exocytosis Vesicle Docking Regulation Of Insulin Secretion Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways		Na+/Cl- dependent neurotransmitter transporters Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds SLC-mediated transmembrane transport	Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Peptide hormone metabolism Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Insulin processing Serotonin Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Transmission across Chemical Synapses
Drugs		Phentermine Tramadol Guanadrel Sulfate Reboxetine Venlafaxine Atomoxetine Amitriptyline Protriptyline Methylphenidate Imipramine Duloxetine Nortriptyline Amoxapine Mazindol Ergotamine Paroxetine Trimipramine Phenmetrazine Pseudoephedrine Cocaine Maprotiline Diethylpropion Sibutramine Chlorpheniramine Doxepin Nefazodone Desipramine Bupropion Guanethidine Orphenadrine Escitalopram Clomipramine Ephedra Ephedrine Ginkgo biloba MMDA 3,4-Methylenedioxymethamphetamine Dextroamphetamine Methamphetamine Phendimetrazine Nomifensine Amineptine Debrisoquin Milnacipran Mianserin Tapentadol Desvenlafaxine Dexmethylphenidate Levonordefrin Levomilnacipran
Diseases
GWAS
Protein-Protein Interactions		2 interactors: PPP2R1A STX1A	58 interactors: ABCC9 APBA1 ATP4B ATP6V1B1 CACNA1D CCSER2 CDK5 CFTR CPLX1 CSNK2A1 CSNK2A2 DAPK1 KCNB1 NAPA NAPB NSF PSMA3 RAB27A RIMS1 SCNN1A SCNN1B SCNN1G SDCBP SEPT2 SEPT5 SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A9 SNAP23 SNAP25 SNAP29 SNPH STX8 STXBP1 STXBP2 STXBP5 STXBP6 SUMO1P1 SYT1 SYT4 SYT7 SYTL4 TRDMT1 TXLNA TXLNB UNC13B VAMP1 VAMP2 VAMP5 VAMP7 VAMP8 VAPB VIM VPS11 VPS18
Entrez ID		6530	6804
HPRD ID		01232	01721
Ensembl ID		ENSG00000103546	ENSG00000106089
Uniprot IDs		B4DX48 P23975	A8MZ54 Q16623 Q75ME0
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptidyl-serine Dephosphorylation Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Mitotic Nuclear Envelope Reassembly Synaptic Vesicle Fusion To Presynaptic Membrane Nuclear Envelope Reassembly Response To Gravity Positive Regulation Of Neurotransmitter Secretion Membrane Organization Negative Regulation Of JAK-STAT Cascade Glutamate Secretion Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Inactivation Of MAPK Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Synaptic Vesicle Transport Positive Regulation Of Membrane Potential Calcium Ion-dependent Exocytosis Negative Regulation Of Peptidyl-tyrosine Phosphorylation Vesicle Fusion Synaptic Vesicle Exocytosis Acid Secretion Positive Regulation Of Exocytosis Vesicle Docking Involved In Exocytosis Nuclear Envelope Organization Regulation Of Neurotransmitter Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Organelle Fusion Regulation Of Postsynaptic Membrane Potential Regulation Of Cellular Component Organization Vesicle Docking Dicarboxylic Acid Transport Negative Regulation Of MAP Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of JAK-STAT Cascade Membrane Docking Ceramide Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Neurotransmitter Secretion Synaptic Vesicle Transport Positive Regulation Of Synaptic Transmission Membrane Depolarization G2/M Transition Of Mitotic Cell Cycle Nucleus Organization Regulation Of DNA Replication Membrane Fusion Negative Regulation Of Protein Serine/threonine Kinase Activity	Exocytosis Secretion By Cell Neurotransmitter Transport Secretion Regulation Of Exocytosis Regulation Of Neurotransmitter Levels Transport Vesicle-mediated Transport Regulation Of Secretion Neurotransmitter Secretion Synaptic Transmission Cell-cell Signaling Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Synaptic Vesicle Transport Synaptic Vesicle Exocytosis Cellular Localization Positive Regulation Of Exocytosis Regulation Of Cellular Localization Membrane Fusion Glutamate Secretion Establishment Of Vesicle Localization Vesicle Localization Ion Transport Vesicle Fusion Protein Transport Establishment Of Protein Localization Amino Acid Transport Vesicle Docking Organelle Fusion Membrane Docking Establishment Of Organelle Localization Membrane Organization Acid Secretion Vesicle Organization Positive Regulation Of Secretion Organelle Localization Protein Localization Monovalent Inorganic Cation Transport Anion Transport Dicarboxylic Acid Transport Regulated Secretory Pathway Metal Ion Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transport Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Sodium Ion Transport Organic Anion Transport
Tagcloud ?		9k arrb1 atg14 atg4b cage1 cald1 cd9 chrna7 chrnb1 col1 expressional fn1 frap hey1 humn il10r il12 il13 il15 il27 immunochemical informational kpna4 oas vegfc villi villous villus voluntarily	colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence
Tagcloud (Difference) ?		9k arrb1 atg14 atg4b cage1 cald1 cd9 chrna7 chrnb1 col1 expressional fn1 frap hey1 humn il10r il12 il13 il15 il27 immunochemical informational kpna4 oas vegfc villi villous villus voluntarily	colitis colonized died h7 hemolytic hemorrhagic hus isogenic k3995 lysogenic o157 outbreak outbreaks phage phages rabbits reflects shiga spinach stec streptomycin stx2 stx2a stx2c succumbed toxin uremic virulence
Tagcloud (Intersection) ?