SIX3 and NR4A3

Number of citations of the paper that reports this interaction (PMID 12543801)
9

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		SIX3	NR4A3
Gene Name		SIX homeobox 3	nuclear receptor subfamily 4, group A, member 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Transcription Corepressor Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Histone Deacetylase Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Steroid Hormone Receptor Activity Thyroid Hormone Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Protein Import Into Nucleus, Translocation Eye Development Epithelial Cell Maturation Lens Development In Camera-type Eye Optic Vesicle Morphogenesis Transcription From RNA Polymerase II Promoter Brain Development Visual Perception Proximal/distal Axis Specification Neuroblast Differentiation Telencephalon Development Forebrain Anterior/posterior Pattern Specification Forebrain Dorsal/ventral Pattern Formation Cell Proliferation In Forebrain Telencephalon Regionalization Pituitary Gland Development Negative Regulation Of Wnt Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Circadian Behavior Lens Induction In Camera-type Eye Regulation Of Neural Retina Development Lens Fiber Cell Differentiation Neuroblast Migration Regulation Of Cell Cycle Phase Transition Regulation Of Neuroblast Proliferation Apoptotic Process Involved In Development Lens Fiber Cell Apoptotic Process Regulation Of Neural Precursor Cell Proliferation	Mesoderm Formation Transcription Initiation From RNA Polymerase II Promoter Axon Guidance Biological_process Gene Expression Hippocampus Development Intracellular Receptor Signaling Pathway Adult Behavior Organ Regeneration Response To Hydrogen Peroxide Steroid Hormone Mediated Signaling Pathway Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Semicircular Canal Morphogenesis Neuromuscular Process Controlling Balance Vestibular Reflex Positive Regulation Of Leukocyte Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Alcohol and nictotine co-dependence ( 22488850) Metabolite levels ( 21909109)	Dental caries ( 23064961)
Protein-Protein Interactions		7 interactors: AES EYA1 GMNN NR4A3 PAX6 TLE1 TLE3	5 interactors: COPS5 RPS6KA1 SIX3 TRIM28 VHL
Entrez ID		6496	8013
HPRD ID		04756	02766
Ensembl ID		ENSG00000138083	ENSG00000119508
Uniprot IDs		O95343	Q92570
PDB IDs
Enriched GO Terms of Interacting Partners?		Organ Morphogenesis Anatomical Structure Morphogenesis Organ Development Semicircular Canal Morphogenesis System Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Semicircular Canal Development RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Anoikis Multicellular Organismal Development Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Neuron Fate Specification Developmental Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Wnt Signaling Pathway Establishment Of Mitotic Spindle Orientation Gene Expression Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Cellular Macromolecule Biosynthetic Process Embryonic Organ Morphogenesis Macromolecule Biosynthetic Process Spindle Localization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neuron Fate Commitment Embryonic Organ Development Negative Regulation Of Gene Expression Pancreatic A Cell Development Forebrain-midbrain Boundary Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Somatic Motor Neuron Fate Commitment Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Cell Fate Specification Inner Ear Morphogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Apoptotic Process Establishment Of Cell Polarity Sensory Organ Development	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Neuroblast Migration Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Negative Regulation Of DNA Demethylation Optic Vesicle Morphogenesis Positive Regulation Of Hepatic Stellate Cell Activation Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Anatomical Structure Morphogenesis Regulation Of Neural Retina Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Lens Fiber Cell Apoptotic Process Neuroblast Differentiation Exosomal Secretion Cell Morphogenesis Negative Regulation Of Transcription, DNA-templated Proximal/distal Axis Specification Convergent Extension Involved In Axis Elongation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Genetic Imprinting DNA Methylation Involved In Embryo Development Cellular Protein Modification Process Negative Regulation Of Gene Expression Stem Cell Differentiation Negative Regulation Of Biosynthetic Process Forebrain Anterior/posterior Pattern Specification Cullin Deneddylation Forebrain Dorsal/ventral Pattern Formation Lens Induction In Camera-type Eye Protein Deneddylation Cellular Response To Stress Regulation Of Cell Differentiation Convergent Extension Telencephalon Regionalization Negative Regulation Of Viral Release From Host Cell Regulation Of Metabolic Process
Tagcloud ?		accompany acetyltransferases alphaa alphab aphakia cbp conditional crystallins discontinuation ectoderm ectodermal embryologic fate integral k18 k27 k27me3 k4me3 k9ac lens organogenesis pax6 placode posttranslational prone sox2 specification subtly unaltered	annotation ccaat cebpd crosstalk cytoscape degs dissect downloaded encyclopedia fbj fosb gse14245 gse21654 gse32676 hub klf5 kruppel kyoto logarithm logfc omnibus ontology pentraxin ppi ptx3 sfn stratifin tfs trasfac
Tagcloud (Difference) ?		accompany acetyltransferases alphaa alphab aphakia cbp conditional crystallins discontinuation ectoderm ectodermal embryologic fate integral k18 k27 k27me3 k4me3 k9ac lens organogenesis pax6 placode posttranslational prone sox2 specification subtly unaltered	annotation ccaat cebpd crosstalk cytoscape degs dissect downloaded encyclopedia fbj fosb gse14245 gse21654 gse32676 hub klf5 kruppel kyoto logarithm logfc omnibus ontology pentraxin ppi ptx3 sfn stratifin tfs trasfac
Tagcloud (Intersection) ?