SIX3 and AES

Number of citations of the paper that reports this interaction (PMID 12050133)
52

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		SIX3	AES
Gene Name		SIX homeobox 3	amino-terminal enhancer of split
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Transcription Corepressor Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Histone Deacetylase Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Protein Import Into Nucleus, Translocation Eye Development Epithelial Cell Maturation Lens Development In Camera-type Eye Optic Vesicle Morphogenesis Transcription From RNA Polymerase II Promoter Brain Development Visual Perception Proximal/distal Axis Specification Neuroblast Differentiation Telencephalon Development Forebrain Anterior/posterior Pattern Specification Forebrain Dorsal/ventral Pattern Formation Cell Proliferation In Forebrain Telencephalon Regionalization Pituitary Gland Development Negative Regulation Of Wnt Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Circadian Behavior Lens Induction In Camera-type Eye Regulation Of Neural Retina Development Lens Fiber Cell Differentiation Neuroblast Migration Regulation Of Cell Cycle Phase Transition Regulation Of Neuroblast Proliferation Apoptotic Process Involved In Development Lens Fiber Cell Apoptotic Process Regulation Of Neural Precursor Cell Proliferation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Transcription, DNA-templated Multicellular Organismal Development Organ Morphogenesis Negative Regulation Of Gene Expression Wnt Signaling Pathway Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Binding Regulation Of Growth Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Anoikis
Pathways			APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Signaling by Wnt repression of WNT target genes APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer truncations of AMER1 destabilize the destruction complex
Drugs
Diseases
GWAS		Alcohol and nictotine co-dependence ( 22488850) Metabolite levels ( 21909109)
Protein-Protein Interactions		7 interactors: AES EYA1 GMNN NR4A3 PAX6 TLE1 TLE3	138 interactors: ABI2 AEN AR ARHGAP32 ATN1 BAHD1 BCL6 BHLHE40 BIRC7 BYSL C1orf109 C1orf216 C1orf94 C6orf165 CALCOCO2 CAPN1 CARD9 CCDC57 CCL7 CCNJL CCNK CIB3 CPSF7 CRACR2A CRX CTAGE5 DDX6 DGCR6 DIP2A EAF1 EIF4E2 FAM124A FAM124B FBF1 FOXP2 FRS3 FSD2 GABARAP GFAP GFI1B GOLGA2 GORASP2 GRB2 GTF2E1 HMGB1 HNF1A HNRNPF HOMEZ IKZF3 KANK2 KIFC3 KRT13 KRT15 KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 L3MBTL2 LDOC1 LINC00526 LMO1 LMO2 LMO4 LSM2 MAGOHB MAPK14 MBNL1 MED31 MED4 MFAP1 MLX MORF4L2 MSX1 MTUS2 MVP MYO15B NAB2 NCDN NEK6 NOTCH2NL NUDT22 OLIG3 OSGIN1 PARVG POU2F1 PPP1R16A PRDM1 PRKAA1 PRKAA2 PRPF31 PRR3 PTRH2 QARS RBM10 RBPMS REL RELA RFX6 RHOXF2 RIMBP3 RNF31 RPL18A RUNX1 SCNM1 SDCBP SH3GL3 SIX1 SIX2 SIX3 SIX6 SKIL SMAD3 SNCAIP SNRPC SOX5 SRPK2 STK16 STX11 TBX3 TCF4 TMCC2 TRAF1 TRAF2 TRIM26 TRIM27 TRIM41 TSC22D4 TSGA10 TSSK3 U2AF2 UBXN11 VPS37B VPS37C ZBTB24 ZGPAT ZNF576
Entrez ID		6496	166
HPRD ID		04756	02556
Ensembl ID		ENSG00000138083	ENSG00000104964
Uniprot IDs		O95343	Q08117 Q8WY48
PDB IDs
Enriched GO Terms of Interacting Partners?		Organ Morphogenesis Anatomical Structure Morphogenesis Organ Development Semicircular Canal Morphogenesis System Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Semicircular Canal Development RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Anoikis Multicellular Organismal Development Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Neuron Fate Specification Developmental Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Wnt Signaling Pathway Establishment Of Mitotic Spindle Orientation Gene Expression Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Cellular Macromolecule Biosynthetic Process Embryonic Organ Morphogenesis Macromolecule Biosynthetic Process Spindle Localization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neuron Fate Commitment Embryonic Organ Development Negative Regulation Of Gene Expression Pancreatic A Cell Development Forebrain-midbrain Boundary Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Somatic Motor Neuron Fate Commitment Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Cell Fate Specification Inner Ear Morphogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Apoptotic Process Establishment Of Cell Polarity Sensory Organ Development	RNA Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Process Multicellular Organismal Development Cellular Metabolic Process Developmental Process Anatomical Structure Development Positive Regulation Of Cellular Biosynthetic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Organ Morphogenesis Embryo Development Tissue Development RNA Processing RNA Splicing In Utero Embryonic Development Regulation Of Cell Death Organ Development
Tagcloud ?		accompany acetyltransferases alphaa alphab aphakia cbp conditional crystallins discontinuation ectoderm ectodermal embryologic fate integral k18 k27 k27me3 k4me3 k9ac lens organogenesis pax6 placode posttranslational prone sox2 specification subtly unaltered	auger bonefit branemark depths differently friatec germany goteborg implants imz mannheim nobelpharma osseointegrated osseointegration outermost peaks photoelectron pure shifted spectroscopy speculated spray straumann sweden switzerland tio2 titanium waldenburg xps
Tagcloud (Difference) ?		accompany acetyltransferases alphaa alphab aphakia cbp conditional crystallins discontinuation ectoderm ectodermal embryologic fate integral k18 k27 k27me3 k4me3 k9ac lens organogenesis pax6 placode posttranslational prone sox2 specification subtly unaltered	auger bonefit branemark depths differently friatec germany goteborg implants imz mannheim nobelpharma osseointegrated osseointegration outermost peaks photoelectron pure shifted spectroscopy speculated spray straumann sweden switzerland tio2 titanium waldenburg xps
Tagcloud (Intersection) ?