SIX3 and EYA1

Number of citations of the paper that reports this interaction (PMID 10490620)
53

Data Source:
HPRD (in vivo, in vitro)

		SIX3	EYA1
Gene Name		SIX homeobox 3	EYA transcriptional coactivator and phosphatase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Transcription Corepressor Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Histone Deacetylase Binding	RNA Binding Protein Tyrosine Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	Protein Import Into Nucleus, Translocation Eye Development Epithelial Cell Maturation Lens Development In Camera-type Eye Optic Vesicle Morphogenesis Transcription From RNA Polymerase II Promoter Brain Development Visual Perception Proximal/distal Axis Specification Neuroblast Differentiation Telencephalon Development Forebrain Anterior/posterior Pattern Specification Forebrain Dorsal/ventral Pattern Formation Cell Proliferation In Forebrain Telencephalon Regionalization Pituitary Gland Development Negative Regulation Of Wnt Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Circadian Behavior Lens Induction In Camera-type Eye Regulation Of Neural Retina Development Lens Fiber Cell Differentiation Neuroblast Migration Regulation Of Cell Cycle Phase Transition Regulation Of Neuroblast Proliferation Apoptotic Process Involved In Development Lens Fiber Cell Apoptotic Process Regulation Of Neural Precursor Cell Proliferation	Establishment Of Mitotic Spindle Orientation Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Outflow Tract Morphogenesis Double-strand Break Repair Transcription, DNA-templated Pattern Specification Process Sensory Perception Of Sound Anatomical Structure Morphogenesis Response To Ionizing Radiation Striated Muscle Tissue Development Histone Dephosphorylation Protein Sumoylation Cellular Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Peptidyl-tyrosine Dephosphorylation Aorta Morphogenesis Outer Ear Morphogenesis Middle Ear Morphogenesis Regulation Of Neuron Differentiation Positive Regulation Of DNA Repair Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Fate Specification Embryonic Skeletal System Morphogenesis Semicircular Canal Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Pharyngeal System Development Lung Epithelial Cell Differentiation Otic Vesicle Morphogenesis Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Cochlea Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Drugs
Diseases
GWAS		Alcohol and nictotine co-dependence ( 22488850) Metabolite levels ( 21909109)	Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Sleepiness ( 17903308)
Protein-Protein Interactions		7 interactors: AES EYA1 GMNN NR4A3 PAX6 TLE1 TLE3	7 interactors: DACH1 GNAI2 GNAZ GSK3B SIX1 SIX2 SIX3
Entrez ID		6496	2138
HPRD ID		04756	03388
Ensembl ID		ENSG00000138083	ENSG00000104313
Uniprot IDs		O95343	A6NCB9 Q99502
PDB IDs
Enriched GO Terms of Interacting Partners?		Organ Morphogenesis Anatomical Structure Morphogenesis Organ Development Semicircular Canal Morphogenesis System Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Semicircular Canal Development RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Anoikis Multicellular Organismal Development Regulation Of Gene Expression Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Neuron Fate Specification Developmental Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Wnt Signaling Pathway Establishment Of Mitotic Spindle Orientation Gene Expression Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Cellular Macromolecule Biosynthetic Process Embryonic Organ Morphogenesis Macromolecule Biosynthetic Process Spindle Localization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neuron Fate Commitment Embryonic Organ Development Negative Regulation Of Gene Expression Pancreatic A Cell Development Forebrain-midbrain Boundary Formation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Somatic Motor Neuron Fate Commitment Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Cell Fate Specification Inner Ear Morphogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Apoptotic Process Establishment Of Cell Polarity Sensory Organ Development	Protein Localization To Organelle Negative Regulation Of Biosynthetic Process Protein Localization To Nucleus Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Cell Proliferation Mesenchyme Development Middle Ear Morphogenesis Cell Proliferation Nucleocytoplasmic Transport Nuclear Transport Cell Migration Regulation Of Transcription From RNA Polymerase II Promoter Cell Fate Commitment Cell Motility Stem Cell Differentiation Embryonic Organ Morphogenesis Developmental Induction Negative Regulation Of Cellular Metabolic Process Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Locomotion Nephron Morphogenesis Positive Regulation Of Cellular Metabolic Process Pattern Specification Process Embryonic Organ Development Positive Regulation Of Transcription, DNA-templated Neuroblast Migration Mesenchymal Stem Cell Proliferation Cellular Protein Localization Cell Fate Specification Epithelial Cell Differentiation Kidney Morphogenesis Regulation Of Neuron Differentiation Metanephros Development Movement Of Cell Or Subcellular Component Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Stem Cell Proliferation Axis Specification Sensory Organ Development Positive Regulation Of Gene Expression Protein Import Into Nucleus Nuclear Import Ear Morphogenesis Regulation Of Cell Differentiation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Development
Tagcloud ?		accompany acetyltransferases alphaa alphab aphakia cbp conditional crystallins discontinuation ectoderm ectodermal embryologic fate integral k18 k27 k27me3 k4me3 k9ac lens organogenesis pax6 placode posttranslational prone sox2 specification subtly unaltered	amphiphysin bmp7 bred cited1 e13 e15 endowment ensures gammah2ax hypo lhx1 mdm mesenchyme metanephroi nephrogenic nephron npc organogenesis patchy pax2 pax8 pockets renewing sall1 six2 superficially susceptibile thinning wnt4
Tagcloud (Difference) ?		accompany acetyltransferases alphaa alphab aphakia cbp conditional crystallins discontinuation ectoderm ectodermal embryologic fate integral k18 k27 k27me3 k4me3 k9ac lens pax6 placode posttranslational prone sox2 specification subtly unaltered	amphiphysin bmp7 bred cited1 e13 e15 endowment ensures gammah2ax hypo lhx1 mdm mesenchyme metanephroi nephrogenic nephron npc patchy pax2 pax8 pockets renewing sall1 six2 superficially susceptibile thinning wnt4
Tagcloud (Intersection) ?		organogenesis