SHB and IL2RB

Number of citations of the paper that reports this interaction (PMID 12200137)
4

Data Source:
HPRD (in vivo)

		SHB	IL2RB
Gene Name		Src homology 2 domain containing adaptor protein B	interleukin 2 receptor, beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Interleukin-2 Receptor Activity Interleukin-2 Binding
	Biological Process	Angiogenesis Apoptotic Process Signal Transduction Positive Regulation Of Signal Transduction Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway	Protein Complex Assembly Signal Transduction Viral Process Cytokine-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Negative Regulation Of Apoptotic Process
Pathways		EPHA-mediated growth cone collapse Axon guidance Signaling by VEGF EPH-Ephrin signaling VEGFA-VEGFR2 Pathway	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs			Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases
GWAS		Brain structure ( 20171287)	Asthma ( 20860503) Rheumatoid arthritis ( 21653640) Type 1 diabetes autoantibodies ( 21829393)
Protein-Protein Interactions		18 interactors: CRK EPS8 GRAP2 GRB2 IL2RB IL2RG JAK1 JAK3 KDR LAT LCP2 PDGFRA PIK3R1 PLCG1 SLC39A1 SRC VAV1 ZAP70	27 interactors: CISH EIF3B FYN GNB2L1 GRB2 HGS IL15 IL15RA IL2 IL2RA IL2RG JAK1 JAK3 LCK LYN PIK3R1 PTPN6 RAF1 SHB SHC1 SOCS1 SOCS3 STAT1 STAT3 STAT5A STAT5B SYK
Entrez ID		6461	3560
HPRD ID		02635	00896
Ensembl ID			ENSG00000100385
Uniprot IDs		Q15464	P14784
PDB IDs			1ILM 1ILN 2B5I 2ERJ 3QAZ 4GS7
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Fc Receptor Signaling Pathway Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune System Process Immune Response-regulating Signaling Pathway Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Defense Response Platelet Activation Cell Migration Fc-epsilon Receptor Signaling Pathway Cell Motility Positive Regulation Of Immune System Process Positive Regulation Of Signal Transduction Positive Regulation Of Immune Response Blood Coagulation Hemostasis Cell Activation Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of T Cell Activation ERBB Signaling Pathway Intracellular Signal Transduction Response To Interleukin-2 Peptidyl-tyrosine Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Signal Transduction Positive Regulation Of T Cell Activation Regulation Of Body Fluid Levels Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Homotypic Cell-cell Adhesion T Cell Receptor Signaling Pathway Wound Healing Leukocyte Migration Regulation Of Signal Transduction Neurotrophin Signaling Pathway Locomotion Regulation Of Lymphocyte Activation Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Signaling Cell Communication Response To Wounding	Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Hormone Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune Response Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide JAK-STAT Cascade Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Cellular Response To Hormone Stimulus Positive Regulation Of Cell-cell Adhesion Cellular Response To Organic Substance Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Response To Organic Substance Response To Organonitrogen Compound Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Immune Response Regulation Of Lymphocyte Activation Defense Response Response To Hormone Cytokine-mediated Signaling Pathway Immune System Process Regulation Of Cell Activation Cell Activation Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Proliferation Cellular Response To Cytokine Stimulus Intracellular Signal Transduction Regulation Of Cell Adhesion Innate Immune Response Regulation Of Signaling Signaling Regulation Of Lymphocyte Differentiation Regulation Of JAK-STAT Cascade Cell Communication Response To Cytokine Response To Interleukin-2 Regulation Of Protein Metabolic Process Platelet Activation
Tagcloud ?		associate clone cloning csk cytokine element elk far fos gh ghr grb10 grb4 hepatoma huh library member p85 phosphatidylinositol radiolabeled reporter screen sh2 shc spi2 stat5 superfamily transducers transfections	attenuation autocrine coculture coexpression conundrum defining engagement explanation favorable heterotrimer il15 il15ra il2rg infiltrations jak1 leucocyte mechanistic offer overexpress paracrine paradoxical pras40 rnai stat2 stroma subsets tnbc unlike
Tagcloud (Difference) ?		associate clone cloning csk cytokine element elk far fos gh ghr grb10 grb4 hepatoma huh library member p85 phosphatidylinositol radiolabeled reporter screen sh2 shc spi2 stat5 superfamily transducers transfections	attenuation autocrine coculture coexpression conundrum defining engagement explanation favorable heterotrimer il15 il15ra il2rg infiltrations jak1 leucocyte mechanistic offer overexpress paracrine paradoxical pras40 rnai stat2 stroma subsets tnbc unlike
Tagcloud (Intersection) ?