SHB and SLC39A1

Number of citations of the paper that reports this interaction (PMID 10477520)
19

Data Source:
HPRD (two hybrid)

		SHB	SLC39A1
Gene Name		Src homology 2 domain containing adaptor protein B	solute carrier family 39 (zinc transporter), member 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Receptor Binding Zinc Ion Transmembrane Transporter Activity Inorganic Cation Transmembrane Transporter Activity
	Biological Process	Angiogenesis Apoptotic Process Signal Transduction Positive Regulation Of Signal Transduction Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway	Cation Transport Transmembrane Transport Zinc Ion Transmembrane Transport
Pathways		EPHA-mediated growth cone collapse Axon guidance Signaling by VEGF EPH-Ephrin signaling VEGFA-VEGFR2 Pathway	Metal ion SLC transporters Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Zinc influx into cells by the SLC39 gene family Zinc transporters SLC-mediated transmembrane transport
Drugs
Diseases
GWAS		Brain structure ( 20171287)	Lentiform nucleus volume ( 22903471)
Protein-Protein Interactions		18 interactors: CRK EPS8 GRAP2 GRB2 IL2RB IL2RG JAK1 JAK3 KDR LAT LCP2 PDGFRA PIK3R1 PLCG1 SLC39A1 SRC VAV1 ZAP70	8 interactors: CERS2 KCNAB1 KCNAB2 NOTCH3 PLEKHM2 PRKCZ SHB SLC39A2
Entrez ID		6461	27173
HPRD ID		02635	11984
Ensembl ID			ENSG00000143570
Uniprot IDs		Q15464	B4DDY7 Q9NY26
PDB IDs
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Fc Receptor Signaling Pathway Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune System Process Immune Response-regulating Signaling Pathway Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Defense Response Platelet Activation Cell Migration Fc-epsilon Receptor Signaling Pathway Cell Motility Positive Regulation Of Immune System Process Positive Regulation Of Signal Transduction Positive Regulation Of Immune Response Blood Coagulation Hemostasis Cell Activation Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of T Cell Activation ERBB Signaling Pathway Intracellular Signal Transduction Response To Interleukin-2 Peptidyl-tyrosine Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Signal Transduction Positive Regulation Of T Cell Activation Regulation Of Body Fluid Levels Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Homotypic Cell-cell Adhesion T Cell Receptor Signaling Pathway Wound Healing Leukocyte Migration Regulation Of Signal Transduction Neurotrophin Signaling Pathway Locomotion Regulation Of Lymphocyte Activation Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Signaling Cell Communication Response To Wounding	Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Interleukin-5 Secretion Synaptic Transmission Protein Heterooligomerization Positive Regulation Of Interleukin-10 Secretion Positive Regulation Of T-helper 2 Cell Cytokine Production NADPH Oxidation Activation Of Phospholipase D Activity Potassium Ion Transmembrane Transport Potassium Ion Transport Metal Ion Transport Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-5 Production Cell-cell Signaling Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of T Cell Cytokine Production Cation Transmembrane Transport Positive Regulation Of T-helper 2 Cell Differentiation Glomerular Capillary Formation Learning Or Memory Regulation Of Interleukin-10 Secretion Cognition Positive Regulation Of Interleukin-4 Production Positive Regulation Of Insulin Receptor Signaling Pathway Angiogenesis Regulation Of T Cell Cytokine Production Cation Transport Regulation Of Interleukin-5 Production Glomerulus Morphogenesis Positive Regulation Of Type 2 Immune Response
Tagcloud ?		associate clone cloning csk cytokine element elk far fos gh ghr grb10 grb4 hepatoma huh library member p85 phosphatidylinositol radiolabeled reporter screen sh2 shc spi2 stat5 superfamily transducers transfections	aco1 annotations atp7b caco conditioned dcytb duodenal enterocyte fech fth1 hemochromatosis heph hfe1 highlight invariant iron metabolism microarrays modulated nucleocytoplasmic ontological place regard slc11a2 slc11a3 taking tf transcriptomic xenobiotic
Tagcloud (Difference) ?		associate clone cloning csk cytokine element elk far fos gh ghr grb10 grb4 hepatoma huh library member p85 phosphatidylinositol radiolabeled reporter screen sh2 shc spi2 stat5 superfamily transducers transfections	aco1 annotations atp7b caco conditioned dcytb duodenal enterocyte fech fth1 hemochromatosis heph hfe1 highlight invariant iron metabolism microarrays modulated nucleocytoplasmic ontological place regard slc11a2 slc11a3 taking tf transcriptomic xenobiotic
Tagcloud (Intersection) ?