SHB and LAT

Number of citations of the paper that reports this interaction (PMID 12084069)
3

Data Source:
HPRD (in vivo)

		SHB	LAT
Gene Name		Src homology 2 domain containing adaptor protein B	linker for activation of T cells
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane	Immunological Synapse Plasma Membrane Cell-cell Junction COP9 Signalosome Integral Component Of Membrane Mast Cell Granule Membrane Raft
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding
	Biological Process	Angiogenesis Apoptotic Process Signal Transduction Positive Regulation Of Signal Transduction Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway	Lymphocyte Homeostasis Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Blood Coagulation Positive Regulation Of Signal Transduction Gene Expression Calcium-mediated Signaling Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Mast Cell Degranulation Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of T Cell Activation
Pathways		EPHA-mediated growth cone collapse Axon guidance Signaling by VEGF EPH-Ephrin signaling VEGFA-VEGFR2 Pathway	TCR signaling Generation of second messenger molecules GPVI-mediated activation cascade Platelet activation, signaling and aggregation Adaptive Immune System
Drugs
Diseases
GWAS		Brain structure ( 20171287)	Crohn's disease ( 21102463)
Protein-Protein Interactions		18 interactors: CRK EPS8 GRAP2 GRB2 IL2RB IL2RG JAK1 JAK3 KDR LAT LCP2 PDGFRA PIK3R1 PLCG1 SLC39A1 SRC VAV1 ZAP70	28 interactors: CBL CD244 CD4 CD8A FCGR1A FCGR2A FYN GAB2 GRAP GRAP2 GRB2 ITK LCK LCP2 MAP4K1 PIK3R1 PLCG1 PLCG2 PTPN1 PTPRJ SGTA SH3BP2 SHB SLA SYK VAV1 ZAP70 ZHX2
Entrez ID		6461	27040
HPRD ID		02635	03832
Ensembl ID			ENSG00000213658
Uniprot IDs		Q15464	B7WPI0 G5E9K3 O43561
PDB IDs
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Fc Receptor Signaling Pathway Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune System Process Immune Response-regulating Signaling Pathway Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Defense Response Platelet Activation Cell Migration Fc-epsilon Receptor Signaling Pathway Cell Motility Positive Regulation Of Immune System Process Positive Regulation Of Signal Transduction Positive Regulation Of Immune Response Blood Coagulation Hemostasis Cell Activation Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of T Cell Activation ERBB Signaling Pathway Intracellular Signal Transduction Response To Interleukin-2 Peptidyl-tyrosine Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Signal Transduction Positive Regulation Of T Cell Activation Regulation Of Body Fluid Levels Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Homotypic Cell-cell Adhesion T Cell Receptor Signaling Pathway Wound Healing Leukocyte Migration Regulation Of Signal Transduction Neurotrophin Signaling Pathway Locomotion Regulation Of Lymphocyte Activation Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Signaling Cell Communication Response To Wounding	Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune Response Innate Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Fc-epsilon Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of Signal Transduction Immune Response Defense Response Positive Regulation Of Cell Activation Blood Coagulation Hemostasis Immune System Process Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Signal Transduction Signaling Cell Communication Platelet Activation Regulation Of Body Fluid Levels Response To Stress Wound Healing Positive Regulation Of T Cell Activation Regulation Of Signaling Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Activation Leukocyte Activation T Cell Costimulation Leukocyte Migration Positive Regulation Of Cell-cell Adhesion Response To Wounding Positive Regulation Of Cell Adhesion Phagocytosis Lymphocyte Activation Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of T Cell Activation Leukocyte Differentiation
Tagcloud ?		associate clone cloning csk cytokine element elk far fos gh ghr grb10 grb4 hepatoma huh library member p85 phosphatidylinositol radiolabeled reporter screen sh2 shc spi2 stat5 superfamily transducers transfections	abolish acting amp beginning besides box contributed cre deleting element elements exciting extension full herpes initiator lap1 latency latently lats positioned primer simplex start substitution tata true unexplored usf
Tagcloud (Difference) ?		associate clone cloning csk cytokine elk far fos gh ghr grb10 grb4 hepatoma huh library member p85 phosphatidylinositol radiolabeled reporter screen sh2 shc spi2 stat5 superfamily transducers transfections	abolish acting amp beginning besides box contributed cre deleting elements exciting extension full herpes initiator lap1 latency latently lats positioned primer simplex start substitution tata true unexplored usf
Tagcloud (Intersection) ?		element