HIF3A and VHL

Number of citations of the paper that reports this interaction (PMID 12538644)
45

Data Source:
HPRD (in vivo, in vitro)

		HIF3A	VHL
Gene Name		hypoxia inducible factor 3, alpha subunit	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleus Nucleoplasm Mitochondrion Endoplasmic Reticulum Cytosol Membrane Intermediate Filament Cytoskeleton
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Signal Transducer Activity Protein Dimerization Activity	Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Enzyme Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Negative Regulation Of Nucleic Acid-templated Transcription	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Regulation Of Transcription, DNA-templated Proteolysis Negative Regulation Of Cell Proliferation Protein Ubiquitination Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription, DNA-templated Protein Stabilization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia
Pathways		Cellular response to hypoxia Transcriptional regulation of pluripotent stem cells Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Regulation of gene expression by Hypoxia-inducible Factor	Cellular response to hypoxia Antigen processing: Ubiquitination & Proteasome degradation Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: EGLN1 EGLN2 EGLN3 HIF1A HSP90AA1 VHL	85 interactors: ACTB APP AR AURKA CAPN7 CAPZB CBR1 CBX1 CBX3 CCT3 CD44 CDC34 CHEK2 CLU CSNK2A1 CUL2 CUL5 DGKI DNAJA3 DVL2 E2F1 EEF1B2 EPAS1 FKBP8 FLNA FN1 HDAC1 HDAC2 HDAC3 HIF1A HIF1AN HIF3A HIST1H1C HIST1H2BL HIST4H4 HNRNPA2B1 HNRNPD HSPA5 HSPA8 JADE1 KIF2C KIF3A KLF4 LANCL1 MDFI NCL NR4A1 NR4A2 NR4A3 PDCD5 PLD1 POLR2G PRDX1 PRKCD PRKCI PRMT1 PRMT8 PSMC3 RB1CC1 RBPMS RBPMS2 RBX1 RNF139 RPL21 RPL5 RPS15A SARNP SAT2 SKP2 SLC2A1 SLC3A2 SON SP1 TCEB1 TCEB2 TRIM28 UBE2D1 USP20 USP33 UXT VAPB VBP1 YY1AP1 ZNF197 ZNF512B
Entrez ID		64344	7428
HPRD ID		17104	01905
Ensembl ID		ENSG00000124440
Uniprot IDs		B2RBI6 F5H884 H0YDZ5 Q9Y2N7	P40337
PDB IDs			1LM8 1LQB 1VCB 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Peptidyl-proline Hydroxylation Response To Abiotic Stimulus 4-hydroxyproline Metabolic Process Protein Hydroxylation Cellular Response To Stress Oxygen Homeostasis Monocarboxylic Acid Metabolic Process Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Neuron Apoptotic Process Cellular Modified Amino Acid Metabolic Process Alpha-amino Acid Metabolic Process Regulation Of Neuron Death Regulation Of Nitric-oxide Synthase Activity Carboxylic Acid Metabolic Process Small Molecule Metabolic Process Organic Acid Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Amino Acid Metabolic Process Regulation Of Oxidoreductase Activity Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Death Neural Fold Elevation Formation Cardiac Ventricle Development Positive Regulation Of Metabolic Process Embryonic Placenta Development Cellular Response To Stimulus Elastin Metabolic Process Negative Regulation Of CAMP Catabolic Process Cardiac Chamber Development Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Vascular Endothelial Growth Factor Production Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Protein Import Into Mitochondrial Outer Membrane Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Intestinal Epithelial Cell Maturation Placenta Development Regulation Of Transcription, DNA-templated	Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Gene Expression Cellular Metabolic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated RNA Metabolic Process Transcription, DNA-templated Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Metabolic Process Cellular Response To Stress Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Nucleobase-containing Compound Metabolic Process Cellular Response To Oxygen Levels Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Death Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Blood Coagulation Positive Regulation Of Cellular Protein Metabolic Process Hemostasis Heterocycle Metabolic Process Positive Regulation Of Gene Expression Cellular Aromatic Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Body Fluid Levels Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Regulation Of Transcription From RNA Polymerase II Promoter Wound Healing Regulation Of Signal Transduction Response To Stimulus
Tagcloud ?		10b 181a 193a 20a 23b 376c 3p 5p 92b anhydrase ca9 carbonic chemoresistance deep gbm glioblastoma glioma hif1a hypoxia hypoxic isomirs micrornas mir mirnas player signature transcriptome u251mg u87mg	ankyrin attenuates bc belonging binds box collection degenerate elongation elongin hippel inhibiting initially interacting jak lindau motif multifunctional multiprotein participates pol repeat skp1 socs spry stat suppressor von wd
Tagcloud (Difference) ?		10b 181a 193a 20a 23b 376c 3p 5p 92b anhydrase ca9 carbonic chemoresistance deep gbm glioblastoma glioma hif1a hypoxia hypoxic isomirs micrornas mir mirnas player signature transcriptome u251mg u87mg	ankyrin attenuates bc belonging binds box collection degenerate elongation elongin hippel inhibiting initially interacting jak lindau motif multifunctional multiprotein participates pol repeat skp1 socs spry stat suppressor von wd
Tagcloud (Intersection) ?