HIF3A and EGLN2

Number of citations of the paper that reports this interaction (PMID 15474027)
19

Data Source:
HPRD (in vitro)

		HIF3A	EGLN2
Gene Name		hypoxia inducible factor 3, alpha subunit	egl-9 family hypoxia-inducible factor 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytosol
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Signal Transducer Activity Protein Dimerization Activity	Protein Binding Ferrous Iron Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Oxygen Sensor Activity L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Negative Regulation Of Nucleic Acid-templated Transcription	Regulation Of Cell Growth Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Intracellular Estrogen Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Cell Redox Homeostasis Positive Regulation Of Protein Catabolic Process Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia
Pathways		Cellular response to hypoxia Transcriptional regulation of pluripotent stem cells Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Regulation of gene expression by Hypoxia-inducible Factor	Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs
Diseases
GWAS			Chronic obstructive pulmonary disease ( 22080838) Smoking behavior ( 20418890)
Protein-Protein Interactions		6 interactors: EGLN1 EGLN2 EGLN3 HIF1A HSP90AA1 VHL	7 interactors: A2M EPAS1 FAM46A HIF1A HIF3A MOB4 SRPK2
Entrez ID		64344	112398
HPRD ID		17104	06970
Ensembl ID		ENSG00000124440	ENSG00000269858
Uniprot IDs		B2RBI6 F5H884 H0YDZ5 Q9Y2N7	Q96KS0
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Peptidyl-proline Hydroxylation Response To Abiotic Stimulus 4-hydroxyproline Metabolic Process Protein Hydroxylation Cellular Response To Stress Oxygen Homeostasis Monocarboxylic Acid Metabolic Process Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Neuron Apoptotic Process Cellular Modified Amino Acid Metabolic Process Alpha-amino Acid Metabolic Process Regulation Of Neuron Death Regulation Of Nitric-oxide Synthase Activity Carboxylic Acid Metabolic Process Small Molecule Metabolic Process Organic Acid Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Amino Acid Metabolic Process Regulation Of Oxidoreductase Activity Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Death Neural Fold Elevation Formation Cardiac Ventricle Development Positive Regulation Of Metabolic Process Embryonic Placenta Development Cellular Response To Stimulus Elastin Metabolic Process Negative Regulation Of CAMP Catabolic Process Cardiac Chamber Development Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Vascular Endothelial Growth Factor Production Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Protein Import Into Mitochondrial Outer Membrane Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Intestinal Epithelial Cell Maturation Placenta Development Regulation Of Transcription, DNA-templated	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Response To Hypoxia Stem Cell Differentiation Angiogenesis Blood Vessel Morphogenesis Nuclear Speck Organization Neural Fold Elevation Formation Blood Vessel Development Vasculature Development Tissue Remodeling Embryonic Placenta Development Iron Ion Homeostasis Elastin Metabolic Process Negative Regulation Of Complement Activation, Lectin Pathway Cell Maturation Transition Metal Ion Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Vascular Endothelial Growth Factor Production Response To Stress Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Intestinal Epithelial Cell Maturation Placenta Development Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Oxidative Stress Cardiovascular System Development Transcription From RNA Polymerase II Promoter Hemoglobin Biosynthetic Process Axon Transport Of Mitochondrion Wound Healing Involved In Inflammatory Response Oxygen Homeostasis Negative Regulation Of Thymocyte Apoptotic Process Myoblast Fate Commitment Regulation Of Neuron Apoptotic Process Homeostasis Of Number Of Cells B-1 B Cell Homeostasis Stem Cell Development Negative Regulation Of Oxidative Stress-induced Neuron Death Anatomical Structure Formation Involved In Morphogenesis Regulation Of Transforming Growth Factor Beta2 Production Response To Abiotic Stimulus Positive Regulation Of Receptor Biosynthetic Process Lactate Metabolic Process
Tagcloud ?		10b 181a 193a 20a 23b 376c 3p 5p 92b anhydrase ca9 carbonic chemoresistance deep gbm glioblastoma glioma hif1a hypoxia hypoxic isomirs micrornas mir mirnas player signature transcriptome u251mg u87mg	altering avenue cyclin d1 deubiquitinase egln1 egln3 foxo foxo3a hif hydroxylases hydroxylate hydroxylation insights leads pharmacologically prevents prolyl promotes promoting proteasomal regulate repress stability suppresses thereby turn usp9x
Tagcloud (Difference) ?		10b 181a 193a 20a 23b 376c 3p 5p 92b anhydrase ca9 carbonic chemoresistance deep gbm glioblastoma glioma hif1a hypoxia hypoxic isomirs micrornas mir mirnas player signature transcriptome u251mg u87mg	altering avenue cyclin d1 deubiquitinase egln1 egln3 foxo foxo3a hif hydroxylases hydroxylate hydroxylation insights leads pharmacologically prevents prolyl promotes promoting proteasomal regulate repress stability suppresses thereby turn usp9x
Tagcloud (Intersection) ?