SDC1 and CD63

Number of citations of the paper that reports this interaction (PMID 22660413)
51

Data Source:
BioGRID (pull down)

		SDC1	CD63
Gene Name		syndecan 1	CD63 molecule
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Lysosomal Lumen Protein Complex Extracellular Vesicular Exosome	Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Platelet Dense Granule Membrane Intrinsic Component Of Plasma Membrane Late Endosome Membrane Endosome Lumen Melanosome Extracellular Vesicular Exosome Multivesicular Body, Internal Vesicle
	Molecular Function	Glycoprotein Binding Protein Binding Protein C-terminus Binding	Protein Binding
	Biological Process	Retinoid Metabolic Process Ureteric Bud Development Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Inflammatory Response Phototransduction, Visible Light Pathogenesis Response To Toxic Substance Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Wound Healing Lipoprotein Metabolic Process Odontogenesis Response To Hydrogen Peroxide Small Molecule Metabolic Process Myoblast Development Response To Glucocorticoid Response To CAMP Response To Calcium Ion Striated Muscle Cell Development Sertoli Cell Development Canonical Wnt Signaling Pathway Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Vesicular Exosome Assembly	Positive Regulation Of Receptor Internalization Platelet Degranulation Cell-matrix Adhesion Blood Coagulation Protein Transport Cell Migration Platelet Activation Cellular Protein Localization Endosome To Melanosome Transport Pigment Granule Maturation Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Rubidium Ion Transport Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Lipoprotein metabolism MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Metabolism of lipids and lipoproteins Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chylomicron-mediated lipid transport Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Lipid digestion, mobilization, and transport Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Syndecan interactions Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome	Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: APP CASK CCL5 CD63 CTSG CXCL8 ELANE FGF2 HGF IGFBP7 LACRT MDK MMP14 PTN SDCBP	13 interactors: AP4M1 CD82 CD9 HLA-DMB HLA-DRA ITGA6 PI4K2A PTGFRN SDC1 SDCBP SRF TIMP1 VKORC1
Entrez ID		6382	967
HPRD ID		01718	01121
Ensembl ID		ENSG00000115884	ENSG00000135404
Uniprot IDs		P18827	P08962
PDB IDs		4GVC 4GVD
Enriched GO Terms of Interacting Partners?		Cell Migration Locomotion Cell Motility Positive Regulation Of Cellular Metabolic Process Movement Of Cell Or Subcellular Component Response To External Stimulus Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Behavior Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Lipid Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Response To Stress Positive Chemotaxis Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Chemotaxis Interaction With Symbiont Regulation Of Growth Positive Regulation Of Cell Migration Regulation Of Protein Metabolic Process Regulation Of Chemotaxis Positive Regulation Of Cell Motility Secretion Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Locomotion Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Stimulus Response To Organic Substance Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Defense Response Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Protein Metabolic Process Killing By Host Of Symbiont Cells Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Platelet Degranulation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Organ Development Regulation Of Body Fluid Levels	Wound Healing Response To Wounding Blood Coagulation Positive Regulation Of Extracellular Vesicular Exosome Assembly Hemostasis Peptide Antigen Assembly With MHC Class II Protein Complex Regulation Of Extracellular Vesicular Exosome Assembly MHC Class II Protein Complex Assembly Regulation Of Body Fluid Levels Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Positive Regulation Of Organelle Assembly Platelet Activation Cell Junction Assembly Cellular Component Assembly Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Myoblast Differentiation Cell Activation Positive Regulation Of Exocytosis Positive Regulation Of Cellular Component Biogenesis Response To Stress Basophil Degranulation Contractile Actin Filament Bundle Assembly Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Exocytosis Platelet Degranulation Response To Stimulus Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Basophil Activation Polysaccharide Assembly With MHC Class II Protein Complex Myoblast Development Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Beta-amyloid Clearance Negative Regulation Of Trophoblast Cell Migration Cell-cell Junction Assembly Secretion By Cell Establishment Of Localization In Cell Odontogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Regulation Of Exocytosis Immune System Process Striated Muscle Cell Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Positive Regulation Of Transcription By Glucose
Tagcloud ?		alpha3beta1 alpha6beta4 beta4 block c2 competes coupling depends egf engagement engaging extreme her1 integrin laminin ln332 matrix migration penetrating platform qeexyx recognize sdc4 shares spreading syndecan syndecans utilized	acquire apply candidates catabolic cathepsin cathepsins colocalization compartments documents endosomal eventually follows golgi gun hete limp lysosomal mediator proform proteolysis scatters secretable secretory shot sorting storage supposed triggers unstimulated
Tagcloud (Difference) ?		alpha3beta1 alpha6beta4 beta4 block c2 competes coupling depends egf engagement engaging extreme her1 integrin laminin ln332 matrix migration penetrating platform qeexyx recognize sdc4 shares spreading syndecan syndecans utilized	acquire apply candidates catabolic cathepsin cathepsins colocalization compartments documents endosomal eventually follows golgi gun hete limp lysosomal mediator proform proteolysis scatters secretable secretory shot sorting storage supposed triggers unstimulated
Tagcloud (Intersection) ?