CD63 and PI4K2A

Number of citations of the paper that reports this interaction (PMID 11113129)
55

Data Source:
HPRD (in vivo)

		CD63	PI4K2A
Gene Name		CD63 molecule	phosphatidylinositol 4-kinase type 2 alpha
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Platelet Dense Granule Membrane Intrinsic Component Of Plasma Membrane Late Endosome Membrane Endosome Lumen Melanosome Extracellular Vesicular Exosome Multivesicular Body, Internal Vesicle	Mitochondrion Lysosomal Membrane Endosome Golgi Apparatus Cytosol Integral Component Of Plasma Membrane Membrane Cell Junction Dendrite Synaptic Vesicle Membrane BLOC-1 Complex Intrinsic Component Of Membrane Cytoplasmic Vesicle Early Endosome Membrane Growing Cell Tip Presynaptic Membrane Neuron Projection Neuronal Cell Body Perikaryon Host Cell Presynaptic Membrane Membrane Raft Exocytic Vesicle
	Molecular Function	Protein Binding	Magnesium Ion Binding 1-phosphatidylinositol 4-kinase Activity Protein Binding ATP Binding AP-3 Adaptor Complex Binding
	Biological Process	Positive Regulation Of Receptor Internalization Platelet Degranulation Cell-matrix Adhesion Blood Coagulation Protein Transport Cell Migration Platelet Activation Cellular Protein Localization Endosome To Melanosome Transport Pigment Granule Maturation Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Rubidium Ion Transport Positive Regulation Of Integrin-mediated Signaling Pathway	Basophil Degranulation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Phospholipid metabolism PI Metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: AP4M1 CD82 CD9 HLA-DMB HLA-DRA ITGA6 PI4K2A PTGFRN SDC1 SDCBP SRF TIMP1 VKORC1	5 interactors: APP CD63 ECSIT NOS3 RAD23A
Entrez ID		967	55361
HPRD ID		01121	11431
Ensembl ID		ENSG00000135404	ENSG00000155252
Uniprot IDs		P08962	Q9BTU6
PDB IDs
Enriched GO Terms of Interacting Partners?		Wound Healing Response To Wounding Blood Coagulation Positive Regulation Of Extracellular Vesicular Exosome Assembly Hemostasis Peptide Antigen Assembly With MHC Class II Protein Complex Regulation Of Extracellular Vesicular Exosome Assembly MHC Class II Protein Complex Assembly Regulation Of Body Fluid Levels Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Positive Regulation Of Organelle Assembly Platelet Activation Cell Junction Assembly Cellular Component Assembly Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Myoblast Differentiation Cell Activation Positive Regulation Of Exocytosis Positive Regulation Of Cellular Component Biogenesis Response To Stress Basophil Degranulation Contractile Actin Filament Bundle Assembly Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Exocytosis Platelet Degranulation Response To Stimulus Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Basophil Activation Polysaccharide Assembly With MHC Class II Protein Complex Myoblast Development Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Beta-amyloid Clearance Negative Regulation Of Trophoblast Cell Migration Cell-cell Junction Assembly Secretion By Cell Establishment Of Localization In Cell Odontogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Regulation Of Exocytosis Immune System Process Striated Muscle Cell Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Positive Regulation Of Transcription By Glucose	Blood Coagulation Hemostasis Response To Stress Platelet Degranulation Regulation Of Oxidoreductase Activity Regulation Of Body Fluid Levels Wound Healing Response To Wounding Smooth Muscle Hyperplasia Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Platelet Activation Smooth Muscle Adaptation Collateral Sprouting Regulation Of Systemic Arterial Blood Pressure By Endothelin Axon Midline Choice Point Recognition Negative Regulation Of Muscle Hyperplasia Regulation Of Rubidium Ion Transport Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Translation Axon Choice Point Recognition Locomotion Regulation Of The Force Of Heart Contraction By Chemical Signal Arginine Catabolic Process Pigment Granule Maturation Endosome To Melanosome Transport Cellular Response To Stimulus Neuron Remodeling Exocytosis Positive Regulation Of Integrin-mediated Signaling Pathway Cellular Pigment Accumulation Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Guanylate Cyclase Activity Movement Of Cell Or Subcellular Component Ovulation From Ovarian Follicle Negative Regulation Of Hydrolase Activity Nitric Oxide Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Metabolic Process Nitric Oxide Mediated Signal Transduction Posttranscriptional Regulation Of Gene Expression Positive Regulation Of CGMP Biosynthetic Process Negative Regulation Of Platelet Activation Cellular Copper Ion Homeostasis Response To External Stimulus Positive Regulation Of Receptor Internalization Positive Regulation Of CGMP Metabolic Process Arginine Metabolic Process Positive Regulation Of MRNA Catabolic Process Ovulation
Tagcloud ?		acquire apply candidates catabolic cathepsin cathepsins colocalization compartments documents endosomal eventually follows golgi gun hete limp lysosomal mediator proform proteolysis scatters secretable secretory shot sorting storage supposed triggers unstimulated	attachment claims cognate endosomes ethylmaleimide fairly iialpha owing perinuclear phosphatidylinositol phospholipids promiscuous ptdins4p q recycling reside retrograde segregation shielding snare snares subcellular trafficking transferrin tubulo vamp3 vesicle vesicular vti1a
Tagcloud (Difference) ?		acquire apply candidates catabolic cathepsin cathepsins colocalization compartments documents endosomal eventually follows golgi gun hete limp lysosomal mediator proform proteolysis scatters secretable secretory shot sorting storage supposed triggers unstimulated	attachment claims cognate endosomes ethylmaleimide fairly iialpha owing perinuclear phosphatidylinositol phospholipids promiscuous ptdins4p q recycling reside retrograde segregation shielding snare snares subcellular trafficking transferrin tubulo vamp3 vesicle vesicular vti1a
Tagcloud (Intersection) ?