CCL3 and ACKR2

Number of citations of the paper that reports this interaction (PMID 9405404)
30

Data Source:
HPRD (in vivo)

		CCL3	ACKR2
Gene Name		chemokine (C-C motif) ligand 3	atypical chemokine receptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Cytoplasm Cytosol	Early Endosome Actin Filament Plasma Membrane Integral Component Of Plasma Membrane Recycling Endosome
	Molecular Function	Protein Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Binding Chemokine Activity Phospholipase Activator Activity Kinase Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Chemoattractant Activity Identical Protein Binding	Chemokine Receptor Activity Scavenger Receptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	MAPK Cascade Osteoblast Differentiation Cell Activation Monocyte Chemotaxis Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Cytoskeleton Organization Cell-cell Signaling Behavior Regulation Of Cell Shape Response To Toxic Substance Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Signaling Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Neutrophil Chemotaxis Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Catalytic Activity Eosinophil Degranulation Protein Kinase B Signaling Positive Regulation Of Neuron Apoptotic Process Astrocyte Cell Migration Negative Regulation By Host Of Viral Transcription Negative Regulation Of Osteoclast Differentiation Eosinophil Chemotaxis Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Inflammatory Response Positive Regulation Of Calcium-mediated Signaling Positive Chemotaxis Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Positive Regulation Of ERK1 And ERK2 Cascade Response To Cholesterol Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Granulocyte Chemotaxis Positive Regulation Of Calcium Ion Import Positive Regulation Of Natural Killer Cell Chemotaxis	Receptor-mediated Endocytosis Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Multicellular Organismal Development Neutrophil Activation Chemokine-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ACKR2 CCL4 CCR1 CCR3 CCR4 CCR5 CEBPB SRGN TGFB1	16 interactors: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8
Entrez ID		6348	1238
HPRD ID		01656	09095
Ensembl ID		ENSG00000006075	ENSG00000144648
Uniprot IDs		A0N0R1 P10147	O00590
PDB IDs		1B50 1B53 2X69 2X6G 3FPU 3H44 3KBX 3TN1
Enriched GO Terms of Interacting Partners?		Inflammatory Response Chemokine-mediated Signaling Pathway Defense Response Regulation Of Ossification Response To External Stimulus Negative Regulation Of Ossification Chemotaxis Response To Stress Cellular Calcium Ion Homeostasis Locomotion Calcium Ion Homeostasis Immune Response Positive Regulation Of Chemotaxis Positive Regulation Of Behavior Regulation Of Chemotaxis Cellular Metal Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Cation Homeostasis Cytokine-mediated Signaling Pathway Cellular Ion Homeostasis Metal Ion Homeostasis Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Cellular Response To Organic Substance Cellular Chemical Homeostasis Ion Homeostasis Cellular Response To Cytokine Stimulus Immune System Process Regulation Of Bone Mineralization Cellular Homeostasis Response To Cytokine Response To Other Organism Response To Biotic Stimulus Response To Lipopolysaccharide Tolerance Induction Response To Molecule Of Bacterial Origin Response To Organic Substance Positive Regulation Of Locomotion Cell Migration Chemical Homeostasis Cell Motility Cellular Response To Stimulus Dendritic Cell Chemotaxis Regulation Of Fat Cell Differentiation Response To Bacterium Negative Regulation Of Bone Mineralization Cell Chemotaxis G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Biomineral Tissue Development Response To Cholesterol	Cell Chemotaxis Chemotaxis Cell Migration Locomotion Immune Response Cell Motility Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Movement Of Cell Or Subcellular Component Cellular Metal Ion Homeostasis Inflammatory Response Response To External Stimulus Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Leukocyte Migration Cellular Chemical Homeostasis Immune System Process Ion Homeostasis Cellular Homeostasis Leukocyte Chemotaxis Eosinophil Chemotaxis Leukocyte Migration Chemical Homeostasis Eosinophil Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Lymphocyte Migration Defense Response Positive Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Cell Migration Positive Regulation Of Behavior Regulation Of Cell Motility Granulocyte Chemotaxis Regulation Of Chemotaxis Homeostatic Process Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Behavior Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Monocyte Chemotaxis Negative Regulation Of Leukocyte Tethering Or Rolling Negative Regulation Of Leukocyte Migration Cellular Response To Stimulus Response To Stress Regulation Of Granulocyte Chemotaxis
Tagcloud ?		backgroundmonocyte ccl4 ccl7 cd45 chemokines conclusionsour contrasted contributors cxcl1 cxcl10 degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe
Tagcloud (Difference) ?		backgroundmonocyte ccl4 ccl7 cd45 chemokines conclusionsour contrasted contributors cxcl1 cxcl10 degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe
Tagcloud (Intersection) ?