CCL3 and CCL4

Number of citations of the paper that reports this interaction (PMID 11278300)
3

Data Source:
HPRD (in vivo)

		CCL3	CCL4
Gene Name		chemokine (C-C motif) ligand 3	chemokine (C-C motif) ligand 4
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Cytoplasm Cytosol	Extracellular Region Extracellular Space
	Molecular Function	Protein Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Binding Chemokine Activity Phospholipase Activator Activity Kinase Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Chemoattractant Activity Identical Protein Binding	Cytokine Activity Protein Binding Chemokine Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Identical Protein Binding
	Biological Process	MAPK Cascade Osteoblast Differentiation Cell Activation Monocyte Chemotaxis Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Cytoskeleton Organization Cell-cell Signaling Behavior Regulation Of Cell Shape Response To Toxic Substance Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Signaling Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Neutrophil Chemotaxis Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Catalytic Activity Eosinophil Degranulation Protein Kinase B Signaling Positive Regulation Of Neuron Apoptotic Process Astrocyte Cell Migration Negative Regulation By Host Of Viral Transcription Negative Regulation Of Osteoclast Differentiation Eosinophil Chemotaxis Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Inflammatory Response Positive Regulation Of Calcium-mediated Signaling Positive Chemotaxis Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Positive Regulation Of ERK1 And ERK2 Cascade Response To Cholesterol Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Granulocyte Chemotaxis Positive Regulation Of Calcium Ion Import Positive Regulation Of Natural Killer Cell Chemotaxis	Movement Of Cell Or Subcellular Component Inflammatory Response Immune Response Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell-cell Signaling Response To Virus Response To Toxic Substance Negative Regulation By Host Of Viral Transcription Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ACKR2 CCL4 CCR1 CCR3 CCR4 CCR5 CEBPB SRGN TGFB1	8 interactors: ACKR2 CCL3 CCR1 CCR3 CCR5 CCR8 CXCL8 SLC30A2
Entrez ID		6348	6351
HPRD ID		01656	01657
Ensembl ID		ENSG00000006075
Uniprot IDs		A0N0R1 P10147	P13236
PDB IDs		1B50 1B53 2X69 2X6G 3FPU 3H44 3KBX 3TN1	1HUM 1HUN 1JE4 2FFK 2FIN 2X6L 3TN2
Enriched GO Terms of Interacting Partners?		Inflammatory Response Chemokine-mediated Signaling Pathway Defense Response Regulation Of Ossification Response To External Stimulus Negative Regulation Of Ossification Chemotaxis Response To Stress Cellular Calcium Ion Homeostasis Locomotion Calcium Ion Homeostasis Immune Response Positive Regulation Of Chemotaxis Positive Regulation Of Behavior Regulation Of Chemotaxis Cellular Metal Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Cation Homeostasis Cytokine-mediated Signaling Pathway Cellular Ion Homeostasis Metal Ion Homeostasis Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Cellular Response To Organic Substance Cellular Chemical Homeostasis Ion Homeostasis Cellular Response To Cytokine Stimulus Immune System Process Regulation Of Bone Mineralization Cellular Homeostasis Response To Cytokine Response To Other Organism Response To Biotic Stimulus Response To Lipopolysaccharide Tolerance Induction Response To Molecule Of Bacterial Origin Response To Organic Substance Positive Regulation Of Locomotion Cell Migration Chemical Homeostasis Cell Motility Cellular Response To Stimulus Dendritic Cell Chemotaxis Regulation Of Fat Cell Differentiation Response To Bacterium Negative Regulation Of Bone Mineralization Cell Chemotaxis G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Biomineral Tissue Development Response To Cholesterol	Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Chemotaxis Response To Cytokine Positive Regulation Of Cytosolic Calcium Ion Concentration Inflammatory Response Cytokine-mediated Signaling Pathway Cytosolic Calcium Ion Homeostasis Locomotion Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Leukocyte Chemotaxis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Response To External Stimulus Cellular Ion Homeostasis Cellular Response To Organic Substance Cell Chemotaxis Metal Ion Homeostasis Cellular Chemical Homeostasis G-protein Coupled Receptor Signaling Pathway Ion Homeostasis Leukocyte Migration Immune Response Defense Response Cellular Homeostasis Response To Organic Substance Positive Regulation Of Leukocyte Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Leukocyte Migration Chemical Homeostasis Calcium-mediated Signaling Cell Surface Receptor Signaling Pathway Sarcoplasmic Reticulum Calcium Ion Transport Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Dendritic Cell Chemotaxis Regulation Of Chemotaxis Second-messenger-mediated Signaling Immune System Process Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Neutrophil Activation Regulation Of Ion Homeostasis Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Response To Cholesterol Regulation Of Behavior Dendritic Cell Migration
Tagcloud ?		backgroundmonocyte ccl4 ccl7 cd45 chemokines conclusionsour contrasted contributors cxcl1 cxcl10 degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe	acetyltransferase boxes cat chloramphenicol coinciding construct constructs fibrogenesis fibrogenic fibrotic hepatic igfiir inducer latent livers m6p mannose mutagenized p75 participating participation quiescent reporter repressor residing stellate stimulant tetrachloride transcript
Tagcloud (Difference) ?		backgroundmonocyte ccl7 cd45 chemokines conclusionsour contrasted contributors cxcl1 cxcl10 degenerating degenerations deoxynucleotidyl dutp euthanized facs govern ld lux markdawley methodssprague muller nick photoreceptor pigment resultsexposure retinal retinas rpe	acetyltransferase boxes cat chloramphenicol coinciding construct constructs fibrogenesis fibrogenic fibrotic hepatic igfiir inducer latent livers m6p mannose mutagenized p75 participating participation quiescent reporter repressor residing stellate stimulant tetrachloride transcript
Tagcloud (Intersection) ?		ccl4