SCNN1A and SCNN1B

Number of citations of the paper that reports this interaction (PMID 8986818)
86

Data Source:
HPRD (in vivo)

		SCNN1A	SCNN1B
Gene Name		sodium channel, non voltage gated 1 alpha subunit	sodium channel, non voltage gated 1 beta subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Cortical Actin Cytoskeleton Motile Cilium Sodium Channel Complex Ciliary Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Sodium Channel Complex Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding	Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding
	Biological Process	Sodium Ion Transport Excretion Ion Transmembrane Transport Sodium Ion Transmembrane Transport Multicellular Organismal Water Homeostasis Response To Stimulus Sensory Perception Of Taste Sodium Ion Homeostasis Transmembrane Transport	Sodium Ion Transport Excretion Ion Transmembrane Transport Sodium Ion Transmembrane Transport Multicellular Organismal Water Homeostasis Response To Stimulus Sensory Perception Of Taste Sodium Ion Homeostasis Transmembrane Transport
Pathways		Ion channel transport Stimuli-sensing channels	Ion channel transport Stimuli-sensing channels
Drugs		Triamterene Amiloride	Triamterene Amiloride
Diseases
GWAS		Obesity (early onset extreme) ( 23563609)
Protein-Protein Interactions		16 interactors: CSNK2A1 EPN1 HECW1 ITCH NEDD4 NEDD4L SCNN1B SCNN1G SERP1 SNX3 STX1A TSG101 UBE2I USP10 WWP1 WWP2	13 interactors: ANK3 CNTN1 EPN1 HECW1 ITCH NEDD4 NEDD4L NFASC SCNN1A SCNN1D SCNN1G STX1A WWP2
Entrez ID		6337	6338
HPRD ID		02575	02861
Ensembl ID		ENSG00000111319	ENSG00000168447
Uniprot IDs		F5GXE6 P37088	B2R812 P51168
PDB IDs		2M3O
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Viral Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Protein Catabolic Process Viral Life Cycle Proteolysis Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Sodium Ion Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Catabolic Process Interaction With Host Cellular Protein Modification Process Regulation Of Potassium Ion Transmembrane Transporter Activity Protein K63-linked Ubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Potassium Ion Transmembrane Transport Viral Entry Into Host Cell Entry Into Host Cell Excretion Protein Polyubiquitination Regulation Of Signaling Regulation Of Potassium Ion Transport Water Homeostasis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Sodium Ion Transport Negative Regulation Of Cellular Metabolic Process Regulation Of Membrane Potential Regulation Of Cellular Localization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transport Regulation Of Vesicle-mediated Transport Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Transport Regulation Of Transmembrane Transporter Activity Regulation Of Protein Localization Regulation Of Cellular Component Organization Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Regulation Of Sodium Ion Transport Regulation Of Membrane Potential Sodium Ion Homeostasis Protein K63-linked Ubiquitination Positive Regulation Of Sodium Ion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Negative Regulation Of Transporter Activity Protein Polyubiquitination Excretion Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Water Homeostasis Sensory Perception Of Taste Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Sodium Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Regulation Of Ion Transport Negative Regulation Of Sodium Ion Transport Negative Regulation Of Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transport Interaction With Host Locomotion Positive Regulation Of Transport Negative Regulation Of Transport Notch Signaling Pathway Negative Regulation Of Potassium Ion Transport Cellular Macromolecule Catabolic Process Regulation Of Ion Transmembrane Transport Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Synapse Organization Metal Ion Homeostasis Regulation Of Sodium Ion Transmembrane Transporter Activity Viral Life Cycle Positive Regulation Of Ion Transport Sodium Ion Transmembrane Transport Viral Process Regulation Of Membrane Depolarization Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Signal Transduction Ion Homeostasis Protein K48-linked Ubiquitination
Tagcloud ?		aldosterone atp1a1 atpasealpha1 betamethasone breaths compliance corticosteroid corticosteroids elastin enac enacalpha enacbeta epithelia fetuses gestation gr inflation infused infusions intravenously mineralocorticoid mr ovine pressures reabsorption stepwise synergy transcriptomic	aldosterone atp1a1 atpasealpha1 betamethasone breaths compliance corticosteroid corticosteroids elastin enac enacalpha enacbeta epithelia fetuses gestation gr inflation infused infusions intravenously mineralocorticoid mr ovine pressures reabsorption stepwise synergy transcriptomic
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		aldosterone atp1a1 atpasealpha1 betamethasone breaths compliance corticosteroid corticosteroids elastin enac enacalpha enacbeta epithelia fetuses gestation gr inflation infused infusions intravenously mineralocorticoid mr ovine pressures reabsorption stepwise synergy transcriptomic