SCNN1B and ANK3

Number of citations of the paper that reports this interaction (PMID 11997395)
30

Data Source:
HPRD (in vivo)

		SCNN1B	ANK3
Gene Name		sodium channel, non voltage gated 1 beta subunit	ankyrin 3, node of Ranvier (ankyrin G)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Sodium Channel Complex Extracellular Vesicular Exosome	Lysosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Tight Junction Basal Plasma Membrane Cell Surface Intercalated Disc Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Lateral Plasma Membrane Sarcoplasmic Reticulum Z Disc T-tubule Dendrite Neuromuscular Junction Node Of Ranvier Paranode Region Of Axon Sarcolemma Costamere Axon Initial Segment Postsynaptic Membrane
	Molecular Function	Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Spectrin Binding Protein Binding, Bridging Ion Channel Binding Cadherin Binding
	Biological Process	Sodium Ion Transport Excretion Ion Transmembrane Transport Sodium Ion Transmembrane Transport Multicellular Organismal Water Homeostasis Response To Stimulus Sensory Perception Of Taste Sodium Ion Homeostasis Transmembrane Transport	Mitotic Cytokinesis Plasma Membrane Organization Cytoskeletal Anchoring At Plasma Membrane Signal Transduction Axonogenesis Axon Guidance Neuromuscular Junction Development Positive Regulation Of Gene Expression Positive Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Sodium Ion Transport Magnesium Ion Homeostasis Neuronal Action Potential Positive Regulation Of Homotypic Cell-cell Adhesion Golgi To Plasma Membrane Protein Transport Regulation Of Potassium Ion Transport Establishment Of Protein Localization Positive Regulation Of Membrane Potential Cellular Response To Magnesium Ion Membrane Assembly Protein Localization To Plasma Membrane Maintenance Of Protein Location In Plasma Membrane Protein Targeting To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Ion channel transport Stimuli-sensing channels	Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs		Triamterene Amiloride
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 22182935 21926972 18711365) Bipolar disorder and major depressive disorder (combined) ( 20351715) Schizophrenia ( 20185149)
Protein-Protein Interactions		13 interactors: ANK3 CNTN1 EPN1 HECW1 ITCH NEDD4 NEDD4L NFASC SCNN1A SCNN1D SCNN1G STX1A WWP2	12 interactors: FADD FAS HOOK1 KCNC1 MAPK6 PIK3R1 SCN1B SCN2A SCNN1B SMAD2 SMAD3 SPTBN4
Entrez ID		6338	288
HPRD ID		02861	02715
Ensembl ID		ENSG00000168447	ENSG00000151150
Uniprot IDs		B2R812 P51168	Q12955 Q8NAK2
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Regulation Of Sodium Ion Transport Regulation Of Membrane Potential Sodium Ion Homeostasis Protein K63-linked Ubiquitination Positive Regulation Of Sodium Ion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Negative Regulation Of Transporter Activity Protein Polyubiquitination Excretion Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Water Homeostasis Sensory Perception Of Taste Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Sodium Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Regulation Of Ion Transport Negative Regulation Of Sodium Ion Transport Negative Regulation Of Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transport Interaction With Host Locomotion Positive Regulation Of Transport Negative Regulation Of Transport Notch Signaling Pathway Negative Regulation Of Potassium Ion Transport Cellular Macromolecule Catabolic Process Regulation Of Ion Transmembrane Transport Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Synapse Organization Metal Ion Homeostasis Regulation Of Sodium Ion Transmembrane Transporter Activity Viral Life Cycle Positive Regulation Of Ion Transport Sodium Ion Transmembrane Transport Viral Process Regulation Of Membrane Depolarization Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Signal Transduction Ion Homeostasis Protein K48-linked Ubiquitination	Extrinsic Apoptotic Signaling Pathway Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Neuron Apoptotic Process Transmission Of Nerve Impulse Necroptotic Signaling Pathway Primary MiRNA Processing Neuron Death SMAD Protein Complex Assembly Paraxial Mesoderm Morphogenesis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Communication Nodal Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Embryonic Foregut Morphogenesis Positive Regulation Of Endopeptidase Activity Lymphocyte Activation Foregut Morphogenesis Paraxial Mesoderm Development Positive Regulation Of Peptidase Activity Cell Differentiation Regulation Of Cell Differentiation Production Of MiRNAs Involved In Gene Silencing By MiRNA Multicellular Organismal Development Pericardium Development Apoptotic Process Leukocyte Activation Anatomical Structure Development Programmed Cell Death Regulation Of Myeloid Cell Differentiation Signal Transduction Involved In Regulation Of Gene Expression Transport Protein Complex Assembly Cell Death Death Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Necroptotic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Abiotic Stimulus Sodium Ion Transmembrane Transport Regulation Of Cysteine-type Endopeptidase Activity Gene Silencing By MiRNA Membrane Depolarization During Action Potential
Tagcloud ?		aldosterone atp1a1 atpasealpha1 betamethasone breaths compliance corticosteroid corticosteroids elastin enac enacalpha enacbeta epithelia fetuses gestation gr inflation infused infusions intravenously mineralocorticoid mr ovine pressures reabsorption stepwise synergy transcriptomic	add adipocytes algorithms backward bd bipolar categorical chi2 contingency doi escitalopram expand lithium meaningful mp ordinal pkc psychiatry publication remove rs10761482 snp stepwise suffer swedish switches tables takes variance
Tagcloud (Difference) ?		aldosterone atp1a1 atpasealpha1 betamethasone breaths compliance corticosteroid corticosteroids elastin enac enacalpha enacbeta epithelia fetuses gestation gr inflation infused infusions intravenously mineralocorticoid mr ovine pressures reabsorption synergy transcriptomic	add adipocytes algorithms backward bd bipolar categorical chi2 contingency doi escitalopram expand lithium meaningful mp ordinal pkc psychiatry publication remove rs10761482 snp suffer swedish switches tables takes variance
Tagcloud (Intersection) ?		stepwise