ATXN7 and LTBP4

Number of citations of the paper that reports this interaction (PMID 21078624)
14

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ATXN7	LTBP4
Gene Name		ataxin 7	latent transforming growth factor beta binding protein 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Cytoskeleton Nuclear Matrix	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Chromatin Binding Protein Binding	Transforming Growth Factor Beta-activated Receptor Activity Integrin Binding Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Transforming Growth Factor Beta Binding
	Biological Process	Microtubule Cytoskeleton Organization Chromatin Organization Transcription, DNA-templated Nucleus Organization Visual Perception Histone Deubiquitination Negative Regulation Of Phosphorylation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter	Regulation Of Cell Growth Protein Folding Transforming Growth Factor Beta Receptor Signaling Pathway Multicellular Organismal Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Proteolysis Extracellular Matrix Organization Growth Hormone Secretion Regulation Of Cell Differentiation
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS
Protein-Protein Interactions		59 interactors: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN HIST1H3A JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SSFA2 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 VCP VWF	11 interactors: ATN1 ATXN7 CACNA1A CRKL CRY1 FBLN1 FRAT1 GFI1B ITSN2 RAC1 TGFB1
Entrez ID		6314	8425
HPRD ID		06365	05274
Ensembl ID		ENSG00000163635	ENSG00000090006
Uniprot IDs		O15265 Q9UPD8	B3KXY6 Q8N2S1
PDB IDs		2KKR
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Response To Stimulus Cell-substrate Junction Assembly Cell-substrate Adhesion Platelet Degranulation Cellular Localization Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Vesicle-mediated Transport Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Cell Junction Assembly Protein Localization To Tight Junction Regulation Of Metabolic Process Histone Deubiquitination Regulation Of Cellular Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Response To Wounding Regulation Of Protein Catabolic Process Regulation Of Cell Death Protein Ubiquitination Protein Polyubiquitination Blood Coagulation Cellular Protein Modification Process Hemostasis Positive Regulation Of Proteolysis Focal Adhesion Assembly Cellular Component Assembly Protein Localization Extracellular Matrix Disassembly Platelet Activation Regulation Of Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Protein Complex Assembly Regulation Of Signaling Cellular Protein Metabolic Process Protein Localization To Cell Junction Cell Death Death Response To Stress Nervous System Development Positive Regulation Of Protein Catabolic Process Secretion By Cell Substrate Adhesion-dependent Cell Spreading Adherens Junction Assembly Protein Metabolic Process	Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Endocytosis Multicellular Organismal Development Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Kinase Activity Bone Remodeling Positive Regulation Of Catalytic Activity Cerebellar Molecular Layer Development Defense Response To Fungus, Incompatible Interaction Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Regulation Of Cellular Process Regulation Of Vesicle-mediated Transport Dendrite Morphogenesis Developmental Process Negative Regulation Of Transport Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Vestibular Nucleus Development Negative Regulation Of Glucocorticoid Secretion Blue Light Signaling Pathway Active Induction Of Host Immune Response By Virus Cell Death Death Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Morphogenesis Positive Regulation Of Chemotaxis Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Kinase Activity Negative Regulation Of RNA Biosynthetic Process Tissue Remodeling Engulfment Of Apoptotic Cell Negative Regulation Of Hyaluronan Biosynthetic Process Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Macrophage Derived Foam Cell Differentiation Evasion Or Tolerance Of Host Defenses By Virus Response To Blue Light Regulation Of Histone Modification Positive Regulation Of Behavior
Tagcloud ?		accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability	15q24 19q13 20q13 21q21 acquire aggressiveness akt2 angptl4 anoikis bsg cadm2 clustered commonality ctc ctcs dissemination distinctiveness dormancy highlighting intravasation mcrs numbl occult originate plausible signature signatures tff3 tgfbeta
Tagcloud (Difference) ?		accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability	15q24 19q13 20q13 21q21 acquire aggressiveness akt2 angptl4 anoikis bsg cadm2 clustered commonality ctc ctcs dissemination distinctiveness dormancy highlighting intravasation mcrs numbl occult originate plausible signature signatures tff3 tgfbeta
Tagcloud (Intersection) ?