ATXN7 and MATN2

Number of citations of the paper that reports this interaction (PMID 21078624)
14

Data Source:
BioGRID (two hybrid)

		ATXN7	MATN2
Gene Name		ataxin 7	matrilin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Cytoskeleton Nuclear Matrix	Proteinaceous Extracellular Matrix Basement Membrane Extracellular Matrix
	Molecular Function	Chromatin Binding Protein Binding	Molecular_function Calcium Ion Binding Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Chromatin Organization Transcription, DNA-templated Nucleus Organization Visual Perception Histone Deubiquitination Negative Regulation Of Phosphorylation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter	Neuron Migration Axon Guidance Biological_process Glial Cell Migration Dendrite Regeneration Response To Axon Injury
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065)
Protein-Protein Interactions		59 interactors: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN HIST1H3A JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SSFA2 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 VCP VWF	18 interactors: ATXN1 ATXN1L ATXN7 CACNA1A CBFA2T3 COL1A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 DVL3 FBN2 FN1 MATN1 MATN3 MATN4
Entrez ID		6314	4147
HPRD ID		06365	03660
Ensembl ID		ENSG00000163635	ENSG00000132561
Uniprot IDs		O15265 Q9UPD8	O00339 Q8N2G3
PDB IDs		2KKR
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Response To Stimulus Cell-substrate Junction Assembly Cell-substrate Adhesion Platelet Degranulation Cellular Localization Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Vesicle-mediated Transport Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Cell Junction Assembly Protein Localization To Tight Junction Regulation Of Metabolic Process Histone Deubiquitination Regulation Of Cellular Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Response To Wounding Regulation Of Protein Catabolic Process Regulation Of Cell Death Protein Ubiquitination Protein Polyubiquitination Blood Coagulation Cellular Protein Modification Process Hemostasis Positive Regulation Of Proteolysis Focal Adhesion Assembly Cellular Component Assembly Protein Localization Extracellular Matrix Disassembly Platelet Activation Regulation Of Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Protein Complex Assembly Regulation Of Signaling Cellular Protein Metabolic Process Protein Localization To Cell Junction Cell Death Death Response To Stress Nervous System Development Positive Regulation Of Protein Catabolic Process Secretion By Cell Substrate Adhesion-dependent Cell Spreading Adherens Junction Assembly Protein Metabolic Process	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process System Development Multicellular Organismal Development Cell Morphogenesis Involved In Differentiation Anatomical Structure Development Developmental Process Anatomical Structure Morphogenesis Cell Morphogenesis Organ Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Axon Guidance Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Neuron Projection Development Locomotion Cell Development Cell Projection Morphogenesis Cell Part Morphogenesis Bone Trabecula Formation Axonogenesis Cell Differentiation Neuron Development Axon Development Movement Of Cell Or Subcellular Component Chemotaxis Glomerular Basement Membrane Development Anatomical Structure Formation Involved In Morphogenesis Generation Of Neurons Bone Trabecula Morphogenesis Neuron Differentiation Neurogenesis Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell Projection Organization Catabolic Process Response To External Stimulus Synapse Organization Cardiovascular System Development Cartilage Development Involved In Endochondral Bone Morphogenesis Endodermal Cell Differentiation Blood Vessel Development Vasculature Development Trabecula Morphogenesis Skeletal System Development Neuromuscular Junction Development
Tagcloud ?		accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability	amplifiable analyte angpt2 aptamer c7 cdta clostridium crdl1 difficile du exponential gpvi hold lumavidin luminex multiplexed naphthylmethyl panels picomolar plg radiolabel reagents sandwich selex somamer somamers tryptaminocarbonyl tsp2 wise
Tagcloud (Difference) ?		accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability	amplifiable analyte angpt2 aptamer c7 cdta clostridium crdl1 difficile du exponential gpvi hold lumavidin luminex multiplexed naphthylmethyl panels picomolar plg radiolabel reagents sandwich selex somamer somamers tryptaminocarbonyl tsp2 wise
Tagcloud (Intersection) ?