ATXN7 and CARD10

Number of citations of the paper that reports this interaction (PMID 21078624)
14

Data Source:
BioGRID (two hybrid)

		ATXN7	CARD10
Gene Name		ataxin 7	caspase recruitment domain family, member 10
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Cytoskeleton Nuclear Matrix	Cytoplasm CBM Complex
	Molecular Function	Chromatin Binding Protein Binding	Protein Binding Receptor Signaling Complex Scaffold Activity
	Biological Process	Microtubule Cytoskeleton Organization Chromatin Organization Transcription, DNA-templated Nucleus Organization Visual Perception Histone Deubiquitination Negative Regulation Of Phosphorylation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter	Protein Complex Assembly Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Apoptotic Process
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS			Optic disc parameters ( 21307088)
Protein-Protein Interactions		59 interactors: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN HIST1H3A JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SSFA2 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 VCP VWF	4 interactors: ATXN7 BCL10 IKBKG KLHL12
Entrez ID		6314	29775
HPRD ID		06365	06233
Ensembl ID		ENSG00000163635	ENSG00000100065
Uniprot IDs		O15265 Q9UPD8	Q8NC81 Q9BWT7
PDB IDs		2KKR
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Response To Stimulus Cell-substrate Junction Assembly Cell-substrate Adhesion Platelet Degranulation Cellular Localization Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Vesicle-mediated Transport Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Cell Junction Assembly Protein Localization To Tight Junction Regulation Of Metabolic Process Histone Deubiquitination Regulation Of Cellular Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Response To Wounding Regulation Of Protein Catabolic Process Regulation Of Cell Death Protein Ubiquitination Protein Polyubiquitination Blood Coagulation Cellular Protein Modification Process Hemostasis Positive Regulation Of Proteolysis Focal Adhesion Assembly Cellular Component Assembly Protein Localization Extracellular Matrix Disassembly Platelet Activation Regulation Of Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Protein Complex Assembly Regulation Of Signaling Cellular Protein Metabolic Process Protein Localization To Cell Junction Cell Death Death Response To Stress Nervous System Development Positive Regulation Of Protein Catabolic Process Secretion By Cell Substrate Adhesion-dependent Cell Spreading Adherens Junction Assembly Protein Metabolic Process	Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signal Transduction Antigen Receptor-mediated Signaling Pathway Activation Of Innate Immune Response Regulation Of Signaling Positive Regulation Of Mast Cell Cytokine Production Lymphotoxin A Biosynthetic Process Interleukin-6 Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Negative Regulation Of Signal Transduction Establishment Of Vesicle Localization Vesicle Localization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Signaling Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Mature B Cell Apoptotic Process Regulation Of Innate Immune Response Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Interleukin-6 Production Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Establishment Of Organelle Localization Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Cytokine Production B Cell Apoptotic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of B Cell Apoptotic Process Organelle Localization Regulation Of Interleukin-8 Biosynthetic Process Immune Response-regulating Signaling Pathway T Cell Apoptotic Process Regulation Of Cytokine Production Regulation Of B Cell Apoptotic Process Histone Deubiquitination COPII Vesicle Coating Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway COPII-coated Vesicle Budding
Tagcloud ?		accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability	100nm 24h 26s 4t1 avenues bortezomib controversial dffb entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome tceb2 top traf3 trp53bp2
Tagcloud (Difference) ?		accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability	100nm 24h 26s 4t1 avenues bortezomib controversial dffb entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome tceb2 top traf3 trp53bp2
Tagcloud (Intersection) ?