BDNF and MBTPS1

Number of citations of the paper that reports this interaction (PMID 9990022)
49

Data Source:
HPRD (in vitro)

		BDNF	MBTPS1
Gene Name		brain-derived neurotrophic factor	membrane-bound transcription factor peptidase, site 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Synaptic Vesicle Cytoplasmic Membrane-bounded Vesicle Mitochondrial Crista Dendrite Terminal Bouton Perikaryon Perinuclear Region Of Cytoplasm	Golgi Membrane Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Stack Integral Component Of Membrane
	Molecular Function	Neurotrophin TRKB Receptor Binding Growth Factor Activity	Serine-type Endopeptidase Activity
	Biological Process	Ureteric Bud Development Behavioral Fear Response Response To Hypoxia Chronic Inflammatory Response Mitochondrial Electron Transport, NADH To Ubiquinone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Nervous System Development Negative Regulation Of Neuroblast Proliferation Axon Guidance Axon Target Recognition Learning Circadian Rhythm Feeding Behavior Neuron Recognition Response To Light Intensity Response To Hormone Response To Auditory Stimulus Glutamate Secretion Response To Fluoxetine Response To Activity Dendrite Development Nerve Development Regulation Of Axon Extension Response To Food Negative Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Peptidyl-serine Phosphorylation Response To Vitamin A Response To Potassium Ion Mechanoreceptor Differentiation Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Striated Muscle Tissue Development Regulation Of Retinal Cell Programmed Cell Death Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Axon Extension Neuron Projection Morphogenesis Inner Ear Development Response To Electrical Stimulus Positive Regulation Of Synapse Assembly Response To Hyperoxia Regulation Of Excitatory Postsynaptic Membrane Potential Taste Bud Development Cellular Response To Tumor Necrosis Factor Cellular Response To Norepinephrine Stimulus Response To Anesthetic Dendrite Extension Response To L-glutamate Cellular Response To Nerve Growth Factor Stimulus	Proteolysis Lipid Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Lysosome Organization Cholesterol Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Membrane Protein Intracellular Domain Proteolysis Response To Endoplasmic Reticulum Stress Regulation Of Transcription Factor Import Into Nucleus Cellular Protein Metabolic Process Small Molecule Metabolic Process
Pathways			Regulation of cholesterol biosynthesis by SREBP (SREBF) Metabolism of lipids and lipoproteins ATF6-alpha activates chaperones Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Body mass index ( 22344221 23563607 19079260 20935630) Obesity ( 21708048 23563607) Smoking behavior ( 20418890) Weight ( 19079260)
Protein-Protein Interactions		14 interactors: AGO3 APP CADPS2 CPE ESR1 F11R INPP5K JUNB MBTPS1 NCAM1 NOS3 NTF3 NTRK2 SORT1	10 interactors: ATF6B BDNF BIRC3 C11orf58 CANX CDK2AP2 SPHK1 TNFRSF14 TNFSF11 ZBED8
Entrez ID		627	8720
HPRD ID		00214	04522
Ensembl ID		ENSG00000176697	ENSG00000140943
Uniprot IDs		P23560	Q14703
PDB IDs		1B8M 1BND
Enriched GO Terms of Interacting Partners?		Signaling Cell Surface Receptor Signaling Pathway Cell Communication Cellular Response To Organic Substance Cellular Response To Stimulus Signal Transduction Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Catalytic Activity Anatomical Structure Development Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Biosynthetic Process Developmental Process Anatomical Structure Morphogenesis Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cell Development Response To External Stimulus Locomotion Multicellular Organismal Development Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Response To Radiation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Gene Expression Regulation Of Cellular Ketone Metabolic Process Cellular Localization Positive Regulation Of Hydrolase Activity Regulation Of Nitric-oxide Synthase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization Regulation Of Protein Phosphorylation Response To Stress Negative Regulation Of Calcium Ion Transport Neurotrophin Signaling Pathway Response To Abiotic Stimulus	Positive Regulation Of Protein Modification Process Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Cytokine Positive Regulation Of Protein Phosphorylation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Secretion Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Stress Regulation Of Protein Phosphorylation Signaling Regulation Of Protein Metabolic Process Cell Communication Response To Anesthetic Positive Regulation Of Corticotropin-releasing Hormone Secretion Response To Fluoxetine Response To L-glutamate Sphingoid Catabolic Process Positive Regulation Of Cell Development Response To Organic Substance Defense Response Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling TNFSF11-mediated Signaling Pathway Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Cytokine Stimulus Positive Regulation Of Protein Ubiquitination Regulation Of Secretion Taste Bud Development Dendrite Extension Cellular Response To Norepinephrine Stimulus Regulation Of Retinal Cell Programmed Cell Death Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Osteoclast Development Positive Regulation Of Transport Cell Surface Receptor Signaling Pathway Osteoclast Proliferation Axon Target Recognition Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Tagcloud ?		accumulated altering believed ca2 causally cerebellar correlates dependency downregulating downregulation elicited evoked excitotoxic excitotoxicity fgf2 fibroblast fura granule neurotrophic nmda nr1 nr2a nr2c prevent protect rnase trauma trophic vulnerable
Tagcloud (Difference) ?		accumulated altering believed ca2 causally cerebellar correlates dependency downregulating downregulation elicited evoked excitotoxic excitotoxicity fgf2 fibroblast fura granule neurotrophic nmda nr1 nr2a nr2c prevent protect rnase trauma trophic vulnerable
Tagcloud (Intersection) ?