BDNF and NCAM1

Number of citations of the paper that reports this interaction (PMID 10760298)
16

Data Source:
HPRD (in vitro)

		BDNF	NCAM1
Gene Name		brain-derived neurotrophic factor	neural cell adhesion molecule 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Synaptic Vesicle Cytoplasmic Membrane-bounded Vesicle Mitochondrial Crista Dendrite Terminal Bouton Perikaryon Perinuclear Region Of Cytoplasm	Golgi Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Neurotrophin TRKB Receptor Binding Growth Factor Activity	Identical Protein Binding
	Biological Process	Ureteric Bud Development Behavioral Fear Response Response To Hypoxia Chronic Inflammatory Response Mitochondrial Electron Transport, NADH To Ubiquinone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Nervous System Development Negative Regulation Of Neuroblast Proliferation Axon Guidance Axon Target Recognition Learning Circadian Rhythm Feeding Behavior Neuron Recognition Response To Light Intensity Response To Hormone Response To Auditory Stimulus Glutamate Secretion Response To Fluoxetine Response To Activity Dendrite Development Nerve Development Regulation Of Axon Extension Response To Food Negative Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Peptidyl-serine Phosphorylation Response To Vitamin A Response To Potassium Ion Mechanoreceptor Differentiation Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Striated Muscle Tissue Development Regulation Of Retinal Cell Programmed Cell Death Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Axon Extension Neuron Projection Morphogenesis Inner Ear Development Response To Electrical Stimulus Positive Regulation Of Synapse Assembly Response To Hyperoxia Regulation Of Excitatory Postsynaptic Membrane Potential Taste Bud Development Cellular Response To Tumor Necrosis Factor Cellular Response To Norepinephrine Stimulus Response To Anesthetic Dendrite Extension Response To L-glutamate Cellular Response To Nerve Growth Factor Stimulus	Cell Adhesion Axon Guidance Cytokine-mediated Signaling Pathway Extracellular Matrix Organization Interferon-gamma-mediated Signaling Pathway
Pathways			Interferon gamma signaling Signal transduction by L1 NCAM1 interactions Axon guidance ECM proteoglycans Interferon Signaling L1CAM interactions Cytokine Signaling in Immune system NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Body mass index ( 22344221 23563607 19079260 20935630) Obesity ( 21708048 23563607) Smoking behavior ( 20418890) Weight ( 19079260)	Entorhinal cortical thickness ( 21116278) Left ventricular mass ( 21212386)
Protein-Protein Interactions		14 interactors: AGO3 APP CADPS2 CPE ESR1 F11R INPP5K JUNB MBTPS1 NCAM1 NOS3 NTF3 NTRK2 SORT1	19 interactors: ATXN1 BDNF EGFR FGFR1 FYN GDNF GFRA1 L1CAM NCAN PLCG1 PPP1CA PRNP RHEB SPTB ST8SIA2 ST8SIA3 ST8SIA4 TUBB UCHL1
Entrez ID		627	4684
HPRD ID		00214	00301
Ensembl ID		ENSG00000176697	ENSG00000149294
Uniprot IDs		P23560	P13591
PDB IDs		1B8M 1BND	2E3V 2HAZ 2VKW 2VKX 3MTR
Enriched GO Terms of Interacting Partners?		Signaling Cell Surface Receptor Signaling Pathway Cell Communication Cellular Response To Organic Substance Cellular Response To Stimulus Signal Transduction Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Catalytic Activity Anatomical Structure Development Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Biosynthetic Process Developmental Process Anatomical Structure Morphogenesis Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cell Development Response To External Stimulus Locomotion Multicellular Organismal Development Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Response To Radiation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Gene Expression Regulation Of Cellular Ketone Metabolic Process Cellular Localization Positive Regulation Of Hydrolase Activity Regulation Of Nitric-oxide Synthase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization Regulation Of Protein Phosphorylation Response To Stress Negative Regulation Of Calcium Ion Transport Neurotrophin Signaling Pathway Response To Abiotic Stimulus	Axonogenesis Axon Guidance Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Chemotaxis Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Movement Of Cell Or Subcellular Component Cell Projection Organization Generation Of Neurons Locomotion Neurogenesis Cell Development Response To External Stimulus Anatomical Structure Morphogenesis Nervous System Development System Development Multicellular Organismal Development Anatomical Structure Development Cell Differentiation Developmental Process Single-organism Behavior Ganglioside Biosynthetic Process Response To Stimulus N-glycan Processing Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Growth Factor Behavior Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Ganglioside Metabolic Process Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Glycosphingolipid Biosynthetic Process Negative Regulation Of Signaling Regulation Of Signal Transduction Learning Or Memory Cognition Axon Target Recognition Cellular Response To Organic Substance Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Oligosaccharide Metabolic Process
Tagcloud ?		accumulated altering believed ca2 causally cerebellar correlates dependency downregulating downregulation elicited evoked excitotoxic excitotoxicity fgf2 fibroblast fura granule neurotrophic nmda nr1 nr2a nr2c prevent protect rnase trauma trophic vulnerable	abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt
Tagcloud (Difference) ?		accumulated altering believed ca2 causally cerebellar correlates dependency downregulating downregulation elicited evoked excitotoxic excitotoxicity fgf2 fibroblast fura granule neurotrophic nmda nr1 nr2a nr2c prevent protect rnase trauma trophic vulnerable	abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt
Tagcloud (Intersection) ?