TRDN and CASQ2

Number of citations of the paper that reports this interaction (PMID 9287354)
99

Data Source:
HPRD (in vivo, in vitro)

		TRDN	CASQ2
Gene Name		triadin	calsequestrin 2 (cardiac muscle)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Plasma Membrane Voltage-gated Calcium Channel Complex Junctional Sarcoplasmic Reticulum Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Junctional Membrane Complex Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Calcium Channel Complex	Intracellular Cytoplasm Voltage-gated Calcium Channel Complex Junctional Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Z Disc Junctional Membrane Complex Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Calcium Channel Complex
	Molecular Function	Receptor Binding Protein Binding Protein Binding, Bridging Protein Homodimerization Activity Ion Channel Binding	Calcium Ion Binding Protein Binding Protein Homodimerization Activity Calcium-dependent Protein Binding
	Biological Process	Cellular Calcium Ion Homeostasis Muscle Contraction Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cytoplasmic Microtubule Organization Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transmembrane Transport Heart Contraction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Membrane Potential Endoplasmic Reticulum Membrane Organization Positive Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction	Regulation Of Heart Rate Detection Of Calcium Ion Striated Muscle Contraction Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transport Sarcomere Organization Sequestering Of Calcium Ion Protein Polymerization Transmembrane Transport Cardiac Muscle Contraction Regulation Of Membrane Repolarization Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Caffeine Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Pathways		Ion channel transport Stimuli-sensing channels	Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS			Ventricular conduction ( 21076409)
Protein-Protein Interactions		5 interactors: ASPH CALM1 CASQ2 HRC RYR1	4 interactors: ANKRD1 CSNK2A1 CSNK2A2 TRDN
Entrez ID		10345	845
HPRD ID		04474	00256
Ensembl ID		ENSG00000186439	ENSG00000118729
Uniprot IDs		H9ME53 Q13061 Q68D40 Q8IVK2	B4DEF0 B4DIB0 O14958
PDB IDs			2VAF
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication By Electrical Coupling Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Ion Homeostasis Muscle Contraction Muscle System Process Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cation Channel Activity Regulation Of Cardiac Muscle Contraction Regulation Of Calcium Ion Transport Into Cytosol Detection Of Calcium Ion Regulation Of Striated Muscle Contraction Calcium-mediated Signaling Regulation Of Ion Transmembrane Transport Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Muscle Contraction Regulation Of Heart Contraction Regulation Of Ion Transport Regulation Of Calcium Ion Transport Regulation Of Heart Rate Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Intracellular Transport Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Response To Calcium Ion Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Caffeine Response To Purine-containing Compound Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Cation Channel Activity Response To Organonitrogen Compound Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Response To Organic Cyclic Compound Response To Caffeine Regulation Of Cellular Localization Positive Regulation Of Cation Channel Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Response To Metal Ion Cellular Response To Alkaloid Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport Negative Regulation Of Ion Transmembrane Transport Detection Of Chemical Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity	Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Endoplasmic Reticulum Membrane Organization Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Organization Cell Differentiation Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Striated Muscle Cell Differentiation Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Regulation Of Cell Division Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Communication By Electrical Coupling Wnt Signaling Pathway Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Muscle Cell Differentiation Generation Of Neurons Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Proteolysis Neurogenesis Response To Muscle Stretch Regulation Of Cardiac Muscle Cell Membrane Potential Negative Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Protein Processing Regulation Of Protein Catabolic Process Axon Guidance Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sarcoplasmic Reticulum Calcium Ion Transport Regulation Of Protein Processing Cell Development Response To External Stimulus Regulation Of Mitotic Cell Cycle
Tagcloud ?			3d aligned alphamhc averaged cardiomyocyte cd172a cms contractile ctnt cvs dissociated ec50 embryoid esc fibrin hes2 hesc inotropy isoproterenol monolayers nn patch patches purity sarcomeres serca2 sirpa uniformly velocities
Tagcloud (Difference) ?			3d aligned alphamhc averaged cardiomyocyte cd172a cms contractile ctnt cvs dissociated ec50 embryoid esc fibrin hes2 hesc inotropy isoproterenol monolayers nn patch patches purity sarcomeres serca2 sirpa uniformly velocities
Tagcloud (Intersection) ?