RTKN and RAC2

Number of citations of the paper that reports this interaction (PMID 12516569)
13

Data Source:
HPRD (in vivo)

		RTKN	RAC2
Gene Name		rhotekin	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component	Nuclear Envelope Cytosol Actin Filament Plasma Membrane Focal Adhesion Lamellipodium Extracellular Vesicular Exosome
	Molecular Function	GTPase Inhibitor Activity Protein Binding GTP Binding GTP-Rho Binding	GTPase Activity GTP Binding
	Biological Process	Apoptotic Process Signal Transduction Rho Protein Signal Transduction Negative Regulation Of Catalytic Activity	Actin Filament Organization Signal Transduction G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Cell Projection Assembly Platelet Activation Bone Resorption Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Respiratory Burst Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration
Pathways			Signaling by GPCR Axon guidance Semaphorin interactions Signaling by Wnt beta-catenin independent WNT signaling Rho GTPase cycle GPCR downstream signaling Signaling by Rho GTPases GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D in semaphorin signaling Platelet activation, signaling and aggregation PCP/CE pathway Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS			Graves' disease ( 23612905) Longevity ( 20834067)
Protein-Protein Interactions		10 interactors: AKAP13 APP GOPC MAP1LC3A RAC2 RHOA RHOC SMURF1 TAX1BP3 TGFBR1	20 interactors: ACTB ADAM22 AFG3L2 ARFIP2 ARHGDIA ARHGDIB CDC42 CHGB CUL1 DEF6 DOCK2 GDI1 ICMT NCF2 NOS2 NOXA1 PAK2 RTKN SMAD1 SMAD4
Entrez ID		6242	5880
HPRD ID		03795	03628
Ensembl ID		ENSG00000114993	ENSG00000128340
Uniprot IDs		Q9BST9	P15153
PDB IDs			1DS6 2W2T 2W2V 2W2X
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Satellite Cell Migration Regulation Of Signal Transduction Wound Healing Small GTPase Mediated Signal Transduction Regulation Of Signaling Response To Wounding Cell Morphogenesis Involved In Differentiation Regulation Of Small GTPase Mediated Signal Transduction Axon Guidance Cell Communication Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Cell Development Intracellular Signal Transduction Cell Morphogenesis Cellular Component Assembly Axonogenesis Neuron Differentiation Cellular Response To Transforming Growth Factor Beta Stimulus Cell Surface Receptor Signaling Pathway Response To Transforming Growth Factor Beta Platelet Activation Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Response To Growth Factor Cellular Response To Stimulus Locomotion Neuron Projection Morphogenesis Cell Differentiation Wound Healing, Spreading Of Cells Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Activation Regulation Of Intracellular Protein Transport Signal Transduction Positive Regulation Of Cell Projection Organization Movement Of Cell Or Subcellular Component Regulation Of Protein Localization Generation Of Neurons Positive Regulation Of Cellular Component Biogenesis Neuron Projection Development Rho Protein Signal Transduction Signaling Cell Projection Morphogenesis Morphogenesis Of An Epithelial Sheet Cell Part Morphogenesis Neurogenesis Enzyme Linked Receptor Protein Signaling Pathway Apical Junction Assembly	Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Developmental Process Multicellular Organismal Development Positive Regulation Of Catalytic Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurogenesis Signal Transduction Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Catalytic Activity Response To External Stimulus Superoxide Metabolic Process Signaling Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell Communication Anatomical Structure Development Response To Stimulus System Development Cell Differentiation Positive Regulation Of Metabolic Process Generation Of Neurons Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Nervous System Development Regulation Of Cell Morphogenesis Innate Immune Response Midbrain Development SMAD Protein Complex Assembly Cellular Response To Stimulus Axonogenesis Defense Response Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Movement Of Cell Or Subcellular Component Reactive Oxygen Species Metabolic Process Regulation Of Cell Adhesion Neuron Projection Morphogenesis Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Defense Response To Virus By Virus Cell Projection Organization Cell Morphogenesis Involved In Differentiation Axon Guidance Regulation Of Protein Catabolic Process Regulation Of Signaling Regulation Of Protein Localization Cell Development
Tagcloud ?			aldrich basket caenorhabditis ced cg32138 collaborate crossvein decapentaplegic deficiencies dominantly draper drpr engulfment enhancers formin hemipterous hippo melanogaster modifiers myoblast pruning puckered rac1 rhoa salvador suppressors wing wiskcott yorkie
Tagcloud (Difference) ?			aldrich basket caenorhabditis ced cg32138 collaborate crossvein decapentaplegic deficiencies dominantly draper drpr engulfment enhancers formin hemipterous hippo melanogaster modifiers myoblast pruning puckered rac1 rhoa salvador suppressors wing wiskcott yorkie
Tagcloud (Intersection) ?