RPL9 and DHPS

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		RPL9	DHPS
Gene Name		ribosomal protein L9	deoxyhypusine synthase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit	Cytosol
	Molecular Function	RNA Binding Structural Constituent Of Ribosome RRNA Binding	Protein Binding Deoxyhypusine Synthase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process	Translation Positive Regulation Of Cell Proliferation Peptidyl-lysine Modification To Peptidyl-hypusine Positive Regulation Of T Cell Proliferation Glucose Homeostasis Post-translational Protein Modification Cellular Protein Metabolic Process Deoxyhypusine Biosynthetic Process From Spermidine Protein Homotetramerization
Pathways		Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Post-translational protein modification Hypusine synthesis from eIF5A-lysine Gamma carboxylation, hypusine formation and arylsulfatase activation
Drugs			Nicotinamide-Adenine-Dinucleotide 1-Guanidinium-7-Aminoheptane
Diseases
GWAS
Protein-Protein Interactions		21 interactors: CALCOCO2 CCDC184 CEP76 DHPS FAM9B HMBOX1 HOMEZ KXD1 MOCS2 MTUS2 PNMA2 RPS3 SORBS2 SPERT TIFA TRIM37 UBALD1 VCP ZBTB14 ZBTB7B ZBTB8A	13 interactors: BRCA1 EIF5A EIF5A2 MAPK3 NIF3L1 NUDT18 PTPRH RAB27B REL RPL9 VASH1 WDYHV1 ZNF138
Entrez ID		6133	1725
HPRD ID		04732	02969
Ensembl ID		ENSG00000163682	ENSG00000095059
Uniprot IDs		P32969 Q53Z07	P49366
PDB IDs		2CQL 3J3B	1DHS 1RLZ 1ROZ 1RQD
Enriched GO Terms of Interacting Partners?		Aggresome Assembly Regulation Of Centriole Replication Regulation Of Centrosome Duplication Regulation Of Centrosome Cycle Positive Regulation Of DNA N-glycosylase Activity Deoxyhypusine Biosynthetic Process From Spermidine Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Spermidine Catabolic Process Biosynthetic Process Histone H2A-K119 Monoubiquitination Transcription, DNA-templated Peptidyl-lysine Modification To Peptidyl-hypusine Positive Regulation Of NF-kappaB Transcription Factor Activity RNA Biosynthetic Process Polyamine Catabolic Process Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Centriole Replication Regulation Of Protein Deubiquitination Nitrogen Compound Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Gene Expression Protein Hexamerization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of DNA Repair Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Microtubule-based Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Heterocycle Metabolic Process Positive Regulation Of Cell Death Translesion Synthesis Histone H2A Monoubiquitination Molybdopterin Cofactor Biosynthetic Process Molybdopterin Cofactor Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Histone H2A Ubiquitination Cytoplasmic Translation Negative Regulation Of Centrosome Duplication	Translational Frameshifting Positive Regulation Of Translational Termination Positive Regulation Of Translational Elongation Regulation Of Translational Termination Peptidyl-lysine Modification To Peptidyl-hypusine Positive Regulation Of Histone Acetylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Protein Complex Disassembly Translational Elongation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Histone Acetylation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Lymphangiogenesis Positive Regulation Of Histone H4-K20 Methylation DGDP Catabolic Process DADP Catabolic Process Positive Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Apolipoprotein Binding Polyamine Homeostasis GDP Catabolic Process Positive Regulation Of Histone Modification Positive Regulation Of Translation Positive Regulation Of Histone H3-K9 Acetylation 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Cellular Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Apoptotic Process Macromolecule Biosynthetic Process Dihydrobiopterin Metabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Programmed Cell Death MRNA Transport Cell Death Regulation Of Protein Complex Disassembly Death Regulation Of Histone Modification Multivesicular Body Sorting Pathway Regulation Of Golgi Inheritance Positive Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process RNA Transport Caveolin-mediated Endocytosis Positive Regulation Of Histone Phosphorylation Cellular Response To Indole-3-methanol RNA Localization
Tagcloud ?		acetyl acetyltransferases begins biogenesis biosynthesis building creb deacetylases e2f e2f1 hub lys nucleolar occupancy orchestrated pan ribosomal ribosome rpl4 rps rps24 rps27a rps6 rrna rrnas sp1 synchronized trimethyl	administrations antihypertensive blocker cas ceb curves diastolic dihydropyridine dihydropyridines dogs exerted felodipine hypertensive intravenous lasting lercanidipine nicardipine nitrendipine orally potency rec reference repeated shr spontaneously starting systolic tachyphylaxis
Tagcloud (Difference) ?		acetyl acetyltransferases begins biogenesis biosynthesis building creb deacetylases e2f e2f1 hub lys nucleolar occupancy orchestrated pan ribosomal ribosome rpl4 rps rps24 rps27a rps6 rrna rrnas sp1 synchronized trimethyl	administrations antihypertensive blocker cas ceb curves diastolic dihydropyridine dihydropyridines dogs exerted felodipine hypertensive intravenous lasting lercanidipine nicardipine nitrendipine orally potency rec reference repeated shr spontaneously starting systolic tachyphylaxis
Tagcloud (Intersection) ?