RPL6 and EIF6

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid, biochemical)
HPRD (two hybrid)

		RPL6	EIF6
Gene Name		ribosomal protein L6	eukaryotic translation initiation factor 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Cytoplasmic Ribonucleoprotein Granule	Nucleus Lamin Filament Nucleoplasm Nucleolus Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	DNA Binding RNA Binding Structural Constituent Of Ribosome Poly(A) RNA Binding	Translation Initiation Factor Activity Protein Binding Ribosome Binding Ribosomal Large Subunit Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Transcription, DNA-templated Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process	Ribosomal Subunit Export From Nucleus Translational Initiation Mature Ribosome Assembly Ribosomal Large Subunit Biogenesis
Pathways		Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Blood pressure ( 21572416) Esophageal cancer ( 21642993)	Height ( 18391951)
Protein-Protein Interactions		12 interactors: CSNK2A1 EIF6 FGF2 IL7R IVNS1ABP MAP3K14 ND1 NFKB2 NPAS2 RPL29 SEL1L STAU1	38 interactors: ABCF1 ACAP3 ACTG1 AKT1S1 ALDH2 APP C4orf27 CLEC4G CRELD1 CSNK2B DHX58 EIF2AK2 ENOX1 FHL2 FUNDC2 GIT1 GNB2L1 HIP1 ITGB4 KIAA1377 LRIF1 MRPS31 OAS3 OFD1 OS9 PDHA1 PLK1 POLA2 PRKCB PSME1 RPL6 SEPT3 TK1 UPF3B USP33 WFS1 XRN2 ZBTB26
Entrez ID		6128	3692
HPRD ID		04745	04221
Ensembl ID		ENSG00000089009	ENSG00000242372
Uniprot IDs		Q02878 Q8TBK5	P56537
PDB IDs		3J3B
Enriched GO Terms of Interacting Partners?		NIK/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling Rhythmic Process Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Follicular Dendritic Cell Differentiation Interleukin-7-mediated Signaling Pathway Negative Regulation Of Cell Death	Positive Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Proteolysis Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cell Cycle Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Proteolysis Regulation Of Translation Positive Regulation Of Peptidase Activity Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Signal Transduction Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Metabolic Process Cell Projection Morphogenesis Cell Projection Organization Response To Stress Cell Part Morphogenesis Gene Expression Axon Guidance Regulation Of Signaling Positive Regulation Of Catalytic Activity Mitotic Cell Cycle Process Regulation Of Binding Negative Regulation Of Defense Response To Virus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Hydrolase Activity Cell Cycle Process Regulation Of Cellular Ketone Metabolic Process Cell Morphogenesis Positive Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Phosphorylation Modification-dependent Protein Catabolic Process Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transferase Activity Axonogenesis Response To External Stimulus Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Innate Immune Response
Tagcloud ?		60s 80s atpases biogenesis comes ebp2 es39l es7l eukaryote excessively helicases machines mak5 multitude nop1 nop16 nop4 nsa1 nucleolus orchestrate ribosomes rix7 rpf1 rpl14 rpl16 rrnas snornp translate translating	40s 60s 80s associates biogenesis cerevisiae cessation depleted designated encodes imbalance lysates maps mer monosomes mr polyribosomes polysomal prevents ribosomal ribosomes saccharomyces stoichiometric subunits tif6 true ultimately xvi yeast
Tagcloud (Difference) ?		atpases comes ebp2 es39l es7l eukaryote excessively helicases machines mak5 multitude nop1 nop16 nop4 nsa1 nucleolus orchestrate rix7 rpf1 rpl14 rpl16 rrnas snornp translate translating	40s associates cerevisiae cessation depleted designated encodes imbalance lysates maps mer monosomes mr polyribosomes polysomal prevents ribosomal saccharomyces stoichiometric subunits tif6 true ultimately xvi yeast
Tagcloud (Intersection) ?		60s 80s biogenesis ribosomes