RECQL and KPNA4

Number of citations of the paper that reports this interaction (PMID 9168958)
25

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid)

		RECQL	KPNA4
Gene Name		RecQ helicase-like	karyopherin alpha 4 (importin alpha 3)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Membrane	Nucleoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	DNA Binding DNA Helicase Activity ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Annealing Helicase Activity ATP-dependent 3'-5' DNA Helicase Activity	Protein Binding Protein Transporter Activity
	Biological Process	DNA Strand Renaturation DNA Replication DNA Repair DNA Recombination DNA Duplex Unwinding	NLS-bearing Protein Import Into Nucleus Cytokine-mediated Signaling Pathway Response To Hydrogen Peroxide
Pathways			ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: KPNA2 KPNA4 RPA1	17 interactors: APP CDKN1B CSE1L CSNK2A1 CUL4B CYHR1 EXO1 HNRNPC KPNB1 MAT2B NUP50 PLAA RAC1 RCC1 RECQL TGM2 TP53
Entrez ID		5965	3840
HPRD ID		02762	04275
Ensembl ID		ENSG00000004700	ENSG00000186432
Uniprot IDs		P46063	O00629
PDB IDs		2V1X 2WWY
Enriched GO Terms of Interacting Partners?		NLS-bearing Protein Import Into Nucleus Protein Import Into Nucleus Nuclear Import Protein Import Protein Localization To Nucleus Nucleocytoplasmic Transport Nuclear Transport DNA Recombinase Assembly Establishment Of Protein Localization To Organelle Protein Targeting Cytokine-mediated Signaling Pathway Protein Localization To Organelle Cellular Response To Cytokine Stimulus Nucleotide-excision Repair, DNA Gap Filling Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Semi-conservative Replication Cytoplasmic Transport Response To Cytokine Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Regulation Of Cellular Response To Heat DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Intracellular Protein Transport Homeostasis Of Number Of Cells Within A Tissue Transcription-coupled Nucleotide-excision Repair DNA Metabolic Process Mismatch Repair Base-excision Repair Cellular Response To Heat Regulation Of DNA Recombination Cellular Protein Localization Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair Protein Transport Establishment Of Protein Localization Nucleotide-excision Repair Intracellular Transport DNA-dependent DNA Replication Response To Heat Response To Hydrogen Peroxide	Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Cell Cycle Process Cell Cycle Cellular Response To Stimulus Regulation Of Cell Cycle Viral Process Positive Regulation Of Cell Cycle DNA Strand Renaturation Mitotic Cell Cycle Arrest Regulation Of Catalytic Activity Mitotic Cell Cycle Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Metabolic Process Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Response To Stimulus Protein Import Into Nucleus, Translocation Nucleobase-containing Compound Metabolic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Protein Complex Assembly Apoptotic Cell Clearance Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Cell Surface Receptor Signaling Pathway Cell Cycle Process Cell Cycle Checkpoint DNA Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Repair Response To Abiotic Stimulus Regulation Of Growth Positive Regulation Of Cell Death DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Neuron Apoptotic Process
Tagcloud ?		affymetrix candidate candidates ccnd1 ccnd3 chosen cisplatin details head hg hour ic50 identifying line map map2k6 microarray microarrays moderately neck others parent resistance squamous tca tca8113 tongue u95av2 validate	9k arrb1 atg14 atg4b cage1 cald1 cd9 chrna7 chrnb1 col1 expressional fn1 frap hey1 humn il10r il12 il13 il15 il27 immunochemical informational oas slc6a2 vegfc villi villous villus voluntarily
Tagcloud (Difference) ?		affymetrix candidate candidates ccnd1 ccnd3 chosen cisplatin details head hg hour ic50 identifying line map map2k6 microarray microarrays moderately neck others parent resistance squamous tca tca8113 tongue u95av2 validate	9k arrb1 atg14 atg4b cage1 cald1 cd9 chrna7 chrnb1 col1 expressional fn1 frap hey1 humn il10r il12 il13 il15 il27 immunochemical informational oas slc6a2 vegfc villi villous villus voluntarily
Tagcloud (Intersection) ?