KPNA4 and EXO1

Number of citations of the paper that reports this interaction (PMID 22222486)
3

Data Source:
BioGRID (pull down)

		KPNA4	EXO1
Gene Name		karyopherin alpha 4 (importin alpha 3)	exonuclease 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Extracellular Vesicular Exosome	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Protein Transporter Activity	DNA Binding RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity 5'-3' Exodeoxyribonuclease Activity Structure-specific DNA Binding Single-stranded DNA 5'-3' Exodeoxyribonuclease Activity Metal Ion Binding Flap Endonuclease Activity Double-stranded DNA 5'-3' Exodeoxyribonuclease Activity
	Biological Process	NLS-bearing Protein Import Into Nucleus Cytokine-mediated Signaling Pathway Response To Hydrogen Peroxide	DNA Catabolic Process, Endonucleolytic DNA Catabolic Process, Exonucleolytic Humoral Immune Response Mediated By Circulating Immunoglobulin DNA Repair Mismatch Repair DNA Recombination Somatic Hypermutation Of Immunoglobulin Genes Isotype Switching Meiotic Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch Repair
Drugs
Diseases
GWAS			Menopause (age at onset) ( 22267201)
Protein-Protein Interactions		17 interactors: APP CDKN1B CSE1L CSNK2A1 CUL4B CYHR1 EXO1 HNRNPC KPNB1 MAT2B NUP50 PLAA RAC1 RCC1 RECQL TGM2 TP53	15 interactors: ATM KPNA4 KPNB1 MLH1 MSH2 MSH3 PCNA PMS2 SFN YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		3840	9156
HPRD ID		04275	06932
Ensembl ID		ENSG00000186432	ENSG00000174371
Uniprot IDs		O00629	Q9UQ84
PDB IDs			3QE9 3QEA 3QEB
Enriched GO Terms of Interacting Partners?		Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Cell Cycle Process Cell Cycle Cellular Response To Stimulus Regulation Of Cell Cycle Viral Process Positive Regulation Of Cell Cycle DNA Strand Renaturation Mitotic Cell Cycle Arrest Regulation Of Catalytic Activity Mitotic Cell Cycle Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Metabolic Process Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Response To Stimulus Protein Import Into Nucleus, Translocation Nucleobase-containing Compound Metabolic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Protein Complex Assembly Apoptotic Cell Clearance Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Cell Surface Receptor Signaling Pathway Cell Cycle Process Cell Cycle Checkpoint DNA Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Repair Response To Abiotic Stimulus Regulation Of Growth Positive Regulation Of Cell Death DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Neuron Apoptotic Process	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Mismatch Repair Regulation Of Organelle Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Organelle Organization Protein Targeting DNA Recombination Regulation Of Intracellular Transport Somatic Recombination Of Immunoglobulin Gene Segments Cellular Response To Stimulus Somatic Diversification Of Immunoglobulins Intracellular Signal Transduction Intracellular Protein Transport Regulation Of Apoptotic Process Immunoglobulin Production Somatic Hypermutation Of Immunoglobulin Genes Regulation Of Cell Death Regulation Of Establishment Of Protein Localization Somatic Diversification Of Immune Receptors Via Somatic Mutation Response To Stimulus Positive Regulation Of Transport Regulation Of Protein Localization System Development Negative Regulation Of DNA Recombination Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Signal Transduction Cellular Response To DNA Damage Stimulus Membrane Organization Response To Stress Cellular Protein Localization Meiosis I Regulation Of Cellular Component Organization Protein Transport Establishment Of Localization In Cell DNA Repair Establishment Of Protein Localization
Tagcloud ?		9k arrb1 atg14 atg4b cage1 cald1 cd9 chrna7 chrnb1 col1 expressional fn1 frap hey1 humn il10r il12 il13 il15 il27 immunochemical informational oas slc6a2 vegfc villi villous villus voluntarily	break dephospho dsb exonuclease forks helicase hu hydroxyurea hypermorphs mec1 mimicking mispaired mlh1 mmr mms msh2 nucleases pol32 pol32delta polymerases rad2 rad53 s372 s567 s587 s692 sgs1 stalled zeta
Tagcloud (Difference) ?		9k arrb1 atg14 atg4b cage1 cald1 cd9 chrna7 chrnb1 col1 expressional fn1 frap hey1 humn il10r il12 il13 il15 il27 immunochemical informational oas slc6a2 vegfc villi villous villus voluntarily	break dephospho dsb exonuclease forks helicase hu hydroxyurea hypermorphs mec1 mimicking mispaired mlh1 mmr mms msh2 nucleases pol32 pol32delta polymerases rad2 rad53 s372 s567 s587 s692 sgs1 stalled zeta
Tagcloud (Intersection) ?