PTPRN and SPTBN4

Number of citations of the paper that reports this interaction (PMID 11086001)
55

Data Source:
HPRD (in vivo, two hybrid)

		PTPRN	SPTBN4
Gene Name		protein tyrosine phosphatase, receptor type, N	spectrin, beta, non-erythrocytic 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane	Cytoplasm Cytosol Plasma Membrane Adherens Junction Spectrin Membrane Nuclear Matrix PML Body Node Of Ranvier Paranode Region Of Axon Neuronal Cell Body Axon Initial Segment Axon Hillock Extracellular Vesicular Exosome Cell Body Fiber
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Spectrin Binding GTPase Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Phosphatase Binding Ankyrin Binding Spectrin Binding
	Biological Process	Response To Reactive Oxygen Species Protein Dephosphorylation Response To Glucose Cytokine-mediated Signaling Pathway Insulin Secretion Response To Insulin Response To Estrogen Response To CAMP Dense Core Granule Maturation	Regulation Of Sodium Ion Transport Cytoskeletal Anchoring At Plasma Membrane Axonogenesis Axon Guidance Sensory Perception Of Sound Adult Walking Behavior Fertilization Negative Regulation Of Heart Rate Vesicle-mediated Transport Transmission Of Nerve Impulse Central Nervous System Projection Neuron Axonogenesis Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Multicellular Organism Growth Clustering Of Voltage-gated Sodium Channels Actin Filament Capping Cardiac Conduction Establishment Of Protein Localization To Plasma Membrane
Pathways			Interaction between L1 and Ankyrins Axon guidance L1CAM interactions NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: CAPN2 CLN8 MADD MAL NOS1 PLP1 PPIA PTPRS PTPRT SNTB2 SNX19 SPTBN4 UBQLN4	12 interactors: ANK3 CDC37 CELSR3 CENPU DISC1 GADD45A GSK3B NEK2 PFDN1 PTPRN PTPRN2 RPS6KA6
Entrez ID		5798	57731
HPRD ID		03466	09372
Ensembl ID		ENSG00000054356	ENSG00000160460
Uniprot IDs		Q16849 Q96IA0	C9JY79 Q9H254
PDB IDs		2I1Y 2QT7 3N01 3N4W 3NG8 3NP5
Enriched GO Terms of Interacting Partners?		Myoblast Fusion Central Nervous System Development Syncytium Formation Regulation Of Cellular Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Adult Walking Behavior Regulation Of Protein Metabolic Process Myotube Differentiation Cell Differentiation Muscle Cell Differentiation Regulation Of Sodium Ion Transport Positive Regulation Of Interleukin-15 Production Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Cytotoxic T Cell Differentiation TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Uncoating Of Virus Anatomical Structure Development Response To Stimulus Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Dense Core Granule Maturation L-glutamate Uptake Involved In Synaptic Transmission Interaction With Host Spinal Cord Development Adult Locomotory Behavior Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Adrenergic Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Serotonin Uptake Membrane Raft Polarization Viral Release From Host Cell Developmental Process Muscle Structure Development Signaling Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of The Force Of Heart Contraction Regulation Of Generation Of L-type Calcium Current Cell Communication Regulation Of Neurotransmitter Levels Cell Maturation Myelination Peptidyl-cysteine S-nitrosylation Membrane Raft Localization Axon Ensheathment Regulation Of Adrenergic Receptor Signaling Pathway Age-dependent Response To Oxidative Stress Regulation Of Heart Contraction Adult Behavior Peptidyl-tyrosine Dephosphorylation	Cell Cycle Organelle Organization Axon Development Cytoskeleton Organization Locomotion Regulation Of Cellular Process Telencephalon Development Centrosome Cycle Nervous System Development Regulation Of Protein Localization Movement Of Cell Or Subcellular Component Maintenance Of Protein Location In Plasma Membrane Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Neuron Projection Development Multicellular Organismal Development Cell Projection Morphogenesis Cellular Response To Mechanical Stimulus Generation Of Neurons Cell Part Morphogenesis Anatomical Structure Development Axon Guidance Neurogenesis Negative Regulation Of Phosphorylation Neuron Development Signal Transduction In Response To DNA Damage Negative Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Delayed Rectifier Potassium Channel Activity Superior Temporal Gyrus Development Dense Core Granule Maturation Canonical Wnt Signaling Pathway Central Nervous System Development Signal Transduction Centrosome Organization Negative Regulation Of Binding Microtubule Cytoskeleton Organization Forebrain Development Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Cycle Process Cell Morphogenesis Microtubule Organizing Center Organization Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Regulation Of Centriole-centriole Cohesion Developmental Process Protein Localization Neuron Differentiation Signaling Cell Projection Organization
Tagcloud ?		2j allen atlas b6 bc023892 btg3 bves drd5 edinger egr1 ew ewcp ewpg ghsr housekeeping microdissection neto1 neurogenetic neuropeptides oculomotor peptidergic postn preganglionic projecting publicly punch rcn1 ucn westphal
Tagcloud (Difference) ?		2j allen atlas b6 bc023892 btg3 bves drd5 edinger egr1 ew ewcp ewpg ghsr housekeeping microdissection neto1 neurogenetic neuropeptides oculomotor peptidergic postn preganglionic projecting publicly punch rcn1 ucn westphal
Tagcloud (Intersection) ?