PTPRN and MADD

Number of citations of the paper that reports this interaction (PMID 16273344)
7

Data Source:
HPRD (in vitro, two hybrid)

		PTPRN	MADD
Gene Name		protein tyrosine phosphatase, receptor type, N	MAP-kinase activating death domain
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane	Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Spectrin Binding GTPase Binding	Death Receptor Binding Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity Protein Kinase Activator Activity
	Biological Process	Response To Reactive Oxygen Species Protein Dephosphorylation Response To Glucose Cytokine-mediated Signaling Pathway Insulin Secretion Response To Insulin Response To Estrogen Response To CAMP Dense Core Granule Maturation	Activation Of MAPK Activity Cell Surface Receptor Signaling Pathway Regulation Of Rab Protein Signal Transduction Positive Regulation Of Rab GTPase Activity Regulation Of Apoptotic Process Regulation Of Cell Cycle Execution Phase Of Apoptosis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) HDL cholesterol ( 19060911) Proinsulin levels ( 21873549)
Protein-Protein Interactions		13 interactors: CAPN2 CLN8 MADD MAL NOS1 PLP1 PPIA PTPRS PTPRT SNTB2 SNX19 SPTBN4 UBQLN4	9 interactors: NPDC1 PIDD1 POT1 PTPRN TNFRSF10A TNFRSF10B TNFRSF1A VPS13D YWHAZ
Entrez ID		5798	8567
HPRD ID		03466	04664
Ensembl ID		ENSG00000054356	ENSG00000110514
Uniprot IDs		Q16849 Q96IA0	Q8WXG6
PDB IDs		2I1Y 2QT7 3N01 3N4W 3NG8 3NP5
Enriched GO Terms of Interacting Partners?		Myoblast Fusion Central Nervous System Development Syncytium Formation Regulation Of Cellular Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Adult Walking Behavior Regulation Of Protein Metabolic Process Myotube Differentiation Cell Differentiation Muscle Cell Differentiation Regulation Of Sodium Ion Transport Positive Regulation Of Interleukin-15 Production Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Cytotoxic T Cell Differentiation TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Uncoating Of Virus Anatomical Structure Development Response To Stimulus Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Dense Core Granule Maturation L-glutamate Uptake Involved In Synaptic Transmission Interaction With Host Spinal Cord Development Adult Locomotory Behavior Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Adrenergic Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Serotonin Uptake Membrane Raft Polarization Viral Release From Host Cell Developmental Process Muscle Structure Development Signaling Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of The Force Of Heart Contraction Regulation Of Generation Of L-type Calcium Current Cell Communication Regulation Of Neurotransmitter Levels Cell Maturation Myelination Peptidyl-cysteine S-nitrosylation Membrane Raft Localization Axon Ensheathment Regulation Of Adrenergic Receptor Signaling Pathway Age-dependent Response To Oxidative Stress Regulation Of Heart Contraction Adult Behavior Peptidyl-tyrosine Dephosphorylation	Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Zymogen Activation Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Cell Death Death Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Positive Regulation Of Signal Transduction Intrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Response To Mechanical Stimulus Regulation Of Apoptotic Process Activation Of NF-kappaB-inducing Kinase Activity Protein Processing Regulation Of Cell Death Positive Regulation Of NIK/NF-kappaB Signaling NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Proteolysis Intracellular Signal Transduction Positive Regulation Of Hydrolase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Positive Regulation Of Cellular Protein Metabolic Process Hormone Secretion Positive Regulation Of DNA Strand Elongation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Hormone Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Dense Core Granule Maturation Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Positive Regulation Of Catalytic Activity Telomere Formation Via Telomerase TRAIL-activated Apoptotic Signaling Pathway Regulation Of Proteolysis
Tagcloud ?		2j allen atlas b6 bc023892 btg3 bves drd5 edinger egr1 ew ewcp ewpg ghsr housekeeping microdissection neto1 neurogenetic neuropeptides oculomotor peptidergic postn preganglionic projecting publicly punch rcn1 ucn westphal	abca1 abcg5 abcg8 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl nominally nr1h3 orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4
Tagcloud (Difference) ?		2j allen atlas b6 bc023892 btg3 bves drd5 edinger egr1 ew ewcp ewpg ghsr housekeeping microdissection neto1 neurogenetic neuropeptides oculomotor peptidergic postn preganglionic projecting publicly punch rcn1 ucn westphal	abca1 abcg5 abcg8 atorvastatin causal challenging chow excised fads1 gwas hfd hypertensive list loci lpl nominally nr1h3 orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4
Tagcloud (Intersection) ?