BAK1 and VDAC2

Number of citations of the paper that reports this interaction (PMID 12881569)
152

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		BAK1	VDAC2
Gene Name		BCL2-antagonist/killer 1	voltage-dependent anion channel 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Cytosol Integral Component Of Mitochondrial Outer Membrane Pore Complex	Nucleus Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Nucleoid Pore Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Heat Shock Protein Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Chaperone Binding BH Domain Binding	Nucleotide Binding Protein Binding Voltage-gated Anion Channel Activity Porin Activity
	Biological Process	B Cell Homeostasis B Cell Apoptotic Process Release Of Cytochrome C From Mitochondria Blood Vessel Remodeling Myeloid Cell Homeostasis B Cell Negative Selection Apoptotic Process Brain Development Aging Mitochondrial Fusion Cell Proliferation Negative Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Response To Fungus Response To Mycotoxin Response To UV-C Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Response To Gamma Radiation Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Endocrine Pancreas Development Organ Regeneration Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Negative Regulation Of Peptidyl-serine Phosphorylation Cellular Response To UV Limb Morphogenesis Response To Drug Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Regulation Of Protein Homodimerization Activity Regulation Of Protein Heterodimerization Activity Fibroblast Apoptotic Process Response To Ethanol Positive Regulation Of Proteolysis Regulation Of Mitochondrial Membrane Permeability Post-embryonic Camera-type Eye Morphogenesis Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Vagina Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Thymocyte Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Involved In Patterning Of Blood Vessels	Anion Transport Negative Regulation Of Protein Polymerization Regulation Of Anion Transport Transmembrane Transport Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Programmed Cell Death Activation and oligomerization of BAK protein Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 22700719) Hematological parameters ( 19820697) Mean platelet volume ( 22423221) Obesity-related traits ( 23251661) Platelet counts ( 22139419 23263863 20139978) Testicular germ cell tumor ( 19483681 23666239 23666240)
Protein-Protein Interactions		19 interactors: ARHGDIA BAX BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BID DBN1 ERN1 HERC1 HSD17B4 HSPD1 MCL1 MFN1 NFKBIB TP53 VDAC1 VDAC2	8 interactors: ADRB2 APP BAK1 CYCS ECT2 HK1 NEDD4L RPS3A
Entrez ID		578	7417
HPRD ID		02744	01904
Ensembl ID		ENSG00000030110	ENSG00000165637
Uniprot IDs		Q16611	P45880
PDB IDs		1BXL 2IMS 2IMT 2JBY 2JCN 2M5B 2XPX 2YV6 3I1H 3QBR
Enriched GO Terms of Interacting Partners?		Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Programmed Cell Death Cell Death Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Apoptotic Process Regulation Of Cell Death Neuron Apoptotic Process Mitochondrial Membrane Organization Neuron Death Cellular Response To DNA Damage Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Cell Death Mitochondrion Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Cell Proliferation Regulation Of Signaling Negative Regulation Of Signal Transduction Response To Gamma Radiation Cellular Response To Stress Male Gonad Development Negative Regulation Of Signaling Mitochondrial Transport Positive Regulation Of Mitochondrion Organization Response To Stress	Positive Regulation Of Protein Metabolic Process Transport Response To Oxidative Stress Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Regulation Of Protein Metabolic Process Cellular Chemical Homeostasis Negative Regulation Of Systemic Arterial Blood Pressure Response To Reactive Oxygen Species Homeostatic Process Cellular Homeostasis Positive Regulation Of Catalytic Activity Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Binding Positive Regulation Of Proteolysis Chemical Homeostasis Negative Regulation Of Blood Pressure Apoptotic Signaling Pathway Apoptotic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Programmed Cell Death Regulation Of Sodium Ion Transport Response To Stress Positive Regulation Of Hydrolase Activity Regulation Of Endopeptidase Activity Cell Death Death Regulation Of Protein Phosphorylation Cellular Metal Ion Homeostasis Regulation Of Peptidase Activity Cellular Cation Homeostasis Response To Radiation Cellular Ion Homeostasis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Metal Ion Homeostasis Response To Inorganic Substance Regulation Of Catalytic Activity Activation Of Cysteine-type Endopeptidase Activity Regulation Of Systemic Arterial Blood Pressure Regulation Of Multicellular Organism Growth Regulation Of Phosphorylation Zymogen Activation Positive Regulation Of Cellular Metabolic Process Tissue Remodeling Synaptic Growth At Neuromuscular Junction Positive Regulation Of Caveolin-mediated Endocytosis
Tagcloud ?		akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask	adrenals carbohydrate cholesterol continues enter gonads hormonal hormones initiating interact interacts location mam mature mitochondria mitochondrial ovaries pregnenolone processed processing prolactin reproduction star steroid steroidogenesis steroidogenic terminus tom22 transports
Tagcloud (Difference) ?		akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask	adrenals carbohydrate cholesterol continues enter gonads hormonal hormones initiating interact interacts location mam mature mitochondria mitochondrial ovaries pregnenolone processed processing prolactin reproduction star steroid steroidogenesis steroidogenic terminus tom22 transports
Tagcloud (Intersection) ?