BAK1 and BCL2L2

Number of citations of the paper that reports this interaction (PMID 10381646)
8

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		BAK1	BCL2L2
Gene Name		BCL2-antagonist/killer 1	BCL2-like 2
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Cytosol Integral Component Of Mitochondrial Outer Membrane Pore Complex	Mitochondrial Outer Membrane Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Heat Shock Protein Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Chaperone Binding BH Domain Binding	Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH Domain Binding
	Biological Process	B Cell Homeostasis B Cell Apoptotic Process Release Of Cytochrome C From Mitochondria Blood Vessel Remodeling Myeloid Cell Homeostasis B Cell Negative Selection Apoptotic Process Brain Development Aging Mitochondrial Fusion Cell Proliferation Negative Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Response To Fungus Response To Mycotoxin Response To UV-C Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Response To Gamma Radiation Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Endocrine Pancreas Development Organ Regeneration Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Negative Regulation Of Peptidyl-serine Phosphorylation Cellular Response To UV Limb Morphogenesis Response To Drug Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Regulation Of Protein Homodimerization Activity Regulation Of Protein Heterodimerization Activity Fibroblast Apoptotic Process Response To Ethanol Positive Regulation Of Proteolysis Regulation Of Mitochondrial Membrane Permeability Post-embryonic Camera-type Eye Morphogenesis Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Vagina Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Thymocyte Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Involved In Patterning Of Blood Vessels	Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Apoptotic Process Sertoli Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Programmed Cell Death Activation and oligomerization of BAK protein Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 22700719) Hematological parameters ( 19820697) Mean platelet volume ( 22423221) Obesity-related traits ( 23251661) Platelet counts ( 22139419 23263863 20139978) Testicular germ cell tumor ( 19483681 23666239 23666240)
Protein-Protein Interactions		19 interactors: ARHGDIA BAX BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BID DBN1 ERN1 HERC1 HSD17B4 HSPD1 MCL1 MFN1 NFKBIB TP53 VDAC1 VDAC2	14 interactors: BAD BAK1 BBC3 BCL2L11 BID BIK BMF CCDC155 FATE1 HRK PMAIP1 PPP1CA TCF4 TP53
Entrez ID		578	599
HPRD ID		02744	03569
Ensembl ID		ENSG00000030110	ENSG00000129473
Uniprot IDs		Q16611	Q92843
PDB IDs		1BXL 2IMS 2IMT 2JBY 2JCN 2M5B 2XPX 2YV6 3I1H 3QBR	1MK3 1O0L 1ZY3 2Y6W
Enriched GO Terms of Interacting Partners?		Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Programmed Cell Death Cell Death Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Apoptotic Process Regulation Of Cell Death Neuron Apoptotic Process Mitochondrial Membrane Organization Neuron Death Cellular Response To DNA Damage Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Cell Death Mitochondrion Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Cell Proliferation Regulation Of Signaling Negative Regulation Of Signal Transduction Response To Gamma Radiation Cellular Response To Stress Male Gonad Development Negative Regulation Of Signaling Mitochondrial Transport Positive Regulation Of Mitochondrion Organization Response To Stress	Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Mitochondrion Organization Positive Regulation Of Protein Oligomerization Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Oligomerization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Protein Homooligomerization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Apoptotic Mitochondrial Changes Positive Regulation Of Organelle Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Signal Transduction Regulation Of Membrane Permeability Positive Regulation Of Protein Complex Assembly Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Intracellular Transport Mitochondrial Membrane Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Regulation Of Protein Complex Assembly Regulation Of Organelle Organization Apoptotic Signaling Pathway Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Activation Of Cysteine-type Endopeptidase Activity Mitochondrion Organization Cell Death Death Zymogen Activation Positive Regulation Of Transport Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Regulation Of Cellular Component Organization Regulation Of Signal Transduction Mitochondrial Transport Positive Regulation Of Neuron Death Regulation Of Signaling
Tagcloud ?		akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask	bag1 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2
Tagcloud (Difference) ?		akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask	bag1 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2
Tagcloud (Intersection) ?