BAK1 and HSD17B4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		BAK1	HSD17B4
Gene Name		BCL2-antagonist/killer 1	hydroxysteroid (17-beta) dehydrogenase 4
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Cytosol Integral Component Of Mitochondrial Outer Membrane Pore Complex	Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Heat Shock Protein Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Chaperone Binding BH Domain Binding	3-hydroxyacyl-CoA Dehydrogenase Activity Receptor Binding Long-chain-enoyl-CoA Hydratase Activity Isomerase Activity 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA Hydratase Activity Protein Homodimerization Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity
	Biological Process	B Cell Homeostasis B Cell Apoptotic Process Release Of Cytochrome C From Mitochondria Blood Vessel Remodeling Myeloid Cell Homeostasis B Cell Negative Selection Apoptotic Process Brain Development Aging Mitochondrial Fusion Cell Proliferation Negative Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Response To Fungus Response To Mycotoxin Response To UV-C Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Response To Gamma Radiation Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Endocrine Pancreas Development Organ Regeneration Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Negative Regulation Of Peptidyl-serine Phosphorylation Cellular Response To UV Limb Morphogenesis Response To Drug Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Regulation Of Protein Homodimerization Activity Regulation Of Protein Heterodimerization Activity Fibroblast Apoptotic Process Response To Ethanol Positive Regulation Of Proteolysis Regulation Of Mitochondrial Membrane Permeability Post-embryonic Camera-type Eye Morphogenesis Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Vagina Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Thymocyte Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Involved In Patterning Of Blood Vessels	Very Long-chain Fatty Acid Metabolic Process Osteoblast Differentiation Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Metabolic Process Bile Acid Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Unsaturated Fatty Acid Metabolic Process Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty-acyl-CoA Metabolic Process Medium-chain Fatty-acyl-CoA Metabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Sertoli Cell Development
Pathways		Programmed Cell Death Activation and oligomerization of BAK protein Intrinsic Pathway for Apoptosis	Beta-oxidation of pristanoyl-CoA Bile acid and bile salt metabolism alpha-linolenic acid (ALA) metabolism Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Metabolism of lipids and lipoproteins alpha-linolenic (omega3) and linoleic (omega6) acid metabolism Synthesis of bile acids and bile salts Beta-oxidation of very long chain fatty acids Peroxisomal lipid metabolism
Drugs			NADH Nicotinamide-Adenine-Dinucleotide 3r-Hydroxydecanoyl-Coa
Diseases
GWAS		Chronic lymphocytic leukemia ( 22700719) Hematological parameters ( 19820697) Mean platelet volume ( 22423221) Obesity-related traits ( 23251661) Platelet counts ( 22139419 23263863 20139978) Testicular germ cell tumor ( 19483681 23666239 23666240)
Protein-Protein Interactions		19 interactors: ARHGDIA BAX BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BID DBN1 ERN1 HERC1 HSD17B4 HSPD1 MCL1 MFN1 NFKBIB TP53 VDAC1 VDAC2	7 interactors: ACTB BAK1 CASP9 CDK7 MAPK8 NDRG1 SNCA
Entrez ID		578	3295
HPRD ID		02744	03514
Ensembl ID		ENSG00000030110	ENSG00000133835
Uniprot IDs		Q16611	B2R659 E7ET17 E7EWE5 G5E9S2 P51659
PDB IDs		1BXL 2IMS 2IMT 2JBY 2JCN 2M5B 2XPX 2YV6 3I1H 3QBR	1IKT 1S9C 1ZBQ
Enriched GO Terms of Interacting Partners?		Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Programmed Cell Death Cell Death Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Apoptotic Process Regulation Of Cell Death Neuron Apoptotic Process Mitochondrial Membrane Organization Neuron Death Cellular Response To DNA Damage Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Cell Death Mitochondrion Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Cell Proliferation Regulation Of Signaling Negative Regulation Of Signal Transduction Response To Gamma Radiation Cellular Response To Stress Male Gonad Development Negative Regulation Of Signaling Mitochondrial Transport Positive Regulation Of Mitochondrion Organization Response To Stress	Response To Inorganic Substance Cellular Response To Stress Response To Metal Ion Response To Stress Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Immune System Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Endopeptidase Activity Response To UV Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Activation Regulation Of Cysteine-type Endopeptidase Activity Response To Other Organism Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Biotic Stimulus Positive Regulation Of Intracellular Transport Protein Processing Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Innate Immune Response Signaling Fc Receptor Signaling Pathway Response To External Stimulus Cellular Response To DNA Damage Stimulus Positive Regulation Of Calcium Ion Transport Into Cytosol Cell Communication Membrane Organization Positive Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Response To Lipopolysaccharide Aging Apoptotic Process Response To Molecule Of Bacterial Origin Response To Light Stimulus Programmed Cell Death Apoptotic Signaling Pathway Positive Regulation Of Hydrolase Activity Cell Death Regulation Of Protein Metabolic Process Death Positive Regulation Of Mitochondrion Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway
Tagcloud ?		akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask	aas aass abused anabolic androgenic arr19 cyp11a1 cyp17a1 dax1 disturbed enanthate gnrhr hsd3b1 hsd3b5 insl3 intramuscular leydig lhcgr milieu oppositely prka prlr1 prlr2 prolactin star steroidogenesis steroidogenic testosterone tspo
Tagcloud (Difference) ?		akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask	aas aass abused anabolic androgenic arr19 cyp11a1 cyp17a1 dax1 disturbed enanthate gnrhr hsd3b1 hsd3b5 insl3 intramuscular leydig lhcgr milieu oppositely prka prlr1 prlr2 prolactin star steroidogenesis steroidogenic testosterone tspo
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