PSEN2 and MGEA5

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		PSEN2	MGEA5
Gene Name		presenilin 2	meningioma expressed antigen 5 (hyaluronidase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Kinetochore Nuclear Inner Membrane Mitochondrial Inner Membrane Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Cell Surface Membrane Apical Plasma Membrane Z Disc Axon Growth Cone Neuromuscular Junction Ciliary Rootlet Ciliary Basal Body Neuronal Cell Body Dendritic Shaft Protein Complex Membrane Raft Perinuclear Region Of Cytoplasm	Nucleus Cytosol Membrane
	Molecular Function	Endopeptidase Activity Aspartic-type Endopeptidase Activity Protein Binding	Histone Acetyltransferase Activity Hyalurononglucosaminidase Activity Beta-N-acetylglucosaminidase Activity
	Biological Process	Response To Hypoxia Cell Fate Specification Somitogenesis Negative Regulation Of Protein Phosphorylation Hair Follicle Development Hematopoietic Progenitor Cell Differentiation T Cell Activation Involved In Immune Response Myeloid Leukocyte Differentiation Membrane Protein Ectodomain Proteolysis Calcium Ion Transport Regulation Of Epidermal Growth Factor-activated Receptor Activity Notch Signaling Pathway Notch Receptor Processing Axon Guidance Memory Protein Transport Protein Processing Dorsal/ventral Neural Tube Patterning Embryonic Limb Morphogenesis Forebrain Development Membrane Protein Intracellular Domain Proteolysis Negative Regulation Of Protein Complex Assembly Negative Regulation Of Protein Binding Endoplasmic Reticulum Calcium Ion Homeostasis Intracellular Signal Transduction Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Synaptic Plasticity Lung Alveolus Development Thymus Development Brain Morphogenesis Beta-amyloid Metabolic Process Positive Regulation Of Coagulation T Cell Receptor Signaling Pathway Cardiac Muscle Contraction Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	N-acetylglucosamine Metabolic Process Glycoprotein Catabolic Process Protein Deglycosylation Protein Targeting To Membrane Aging Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Cardiac Muscle Adaptation Histone Acetylation Positive Regulation Of Cell Killing Positive Regulation Of Insulin Secretion Positive Regulation Of Protein Complex Disassembly Positive Regulation Of Proteolysis DATP Metabolic Process Positive Regulation Of Glucose Import Response To Steroid Hormone Positive Regulation Of DNA Metabolic Process Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Protein Glycosylation Positive Regulation Of Growth Hormone Secretion Necrotic Cell Death
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Regulated proteolysis of p75NTR Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by NOTCH p75 NTR receptor-mediated signalling Signaling by ERBB4 NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 NRIF signals cell death from the nucleus Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS
Protein-Protein Interactions		58 interactors: AAMP ACTG1 APH1A APH1B APP BCL2L1 CAPN1 CASP1 CASP3 CASP6 CASP7 CASP8 CEP55 CFLAR CHKA CIB1 CSNK1A1 CSNK1D CSNK2A1 CTNNB1 CTNND2 DNAJB1 DOCK3 ECD EID1 ELAVL1 EVI5L EXOC6 FBXL12 FHL2 FLNA FLNB GCDH GFAP HPS1 ICAM5 IFIT3 IFIT5 KCNIP3 KCNIP4 LIPF MAST1 METTL2B MGEA5 NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PDCD4 PSENEN RAB11A RHEB RNF32 SPC24 SRI UBQLN1	10 interactors: A2M C6 CDC37 CSNK2B DHX9 GSK3B MAST1 OGT PSEN2 RNF32
Entrez ID		5664	10724
HPRD ID		02860	04949
Ensembl ID		ENSG00000143801	ENSG00000198408
Uniprot IDs		P49810	E9PGF9 O60502
PDB IDs			2YDQ
Enriched GO Terms of Interacting Partners?		Notch Receptor Processing Cell Death Death Apoptotic Process Programmed Cell Death Notch Signaling Pathway Regulation Of Apoptotic Process Cell Differentiation Regulation Of Cell Death Cell Development Positive Regulation Of Apoptotic Process Cell Morphogenesis Involved In Differentiation Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Anatomical Structure Morphogenesis Developmental Process Signal Transduction Protein Processing Cellular Response To Stimulus Signaling Execution Phase Of Apoptosis Response To Stimulus Multicellular Organismal Development System Development Cell Communication Anatomical Structure Development Membrane Protein Intracellular Domain Proteolysis Apoptotic Signaling Pathway Cell Morphogenesis Regulation Of Signaling Cell Surface Receptor Signaling Pathway Neuron Differentiation Regulation Of Cellular Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Proteolysis Intracellular Receptor Signaling Pathway Response To External Stimulus Cardiovascular System Development Anatomical Structure Formation Involved In Morphogenesis Angiogenesis Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Positive Regulation Of Peptidase Activity Membrane Protein Proteolysis Positive Regulation Of Catalytic Activity Generation Of Neurons Cell Cycle Negative Regulation Of Cell Death	Regulation Of Protein Metabolic Process Regulation Of Immune System Process Regulation Of Immune Response Axon Guidance Regulation Of Cellular Protein Metabolic Process Axonogenesis Circadian Rhythm Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Protein Metabolic Process Regulation Of Complement Activation Regulation Of Catalytic Activity Cell Morphogenesis Involved In Differentiation Regulation Of Binding Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Neuron Projection Development Regulation Of Humoral Immune Response Regulation Of Signal Transduction Rhythmic Process Cell Projection Morphogenesis Negative Regulation Of Protein Binding Cell Part Morphogenesis Negative Regulation Of Protein Metabolic Process Response To External Stimulus Cellular Response To Heat Neuron Development Intracellular Signal Transduction Regulation Of Signaling Regulation Of Acute Inflammatory Response Regulation Of Generation Of Precursor Metabolites And Energy Cell Morphogenesis Regulation Of Protein Phosphorylation Cell Differentiation Neuron Differentiation Cell Projection Organization Negative Regulation Of Binding Regulation Of Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Glucose Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Negative Regulation Of Complement Activation, Lectin Pathway Locomotion Establishment Of Cell Polarity Response To Heat
Tagcloud ?		abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys picalm posits precede proof psen1 snps sorl1 sporadic triggers turn unlikely	alive bizarre borderline coded confined consultation cytokeratin desmin distinctive eighteen erg fascicular fibroblastic fibrous files fli histiocytoma incomplete nucleoli pleomorphism s100 soft spindled striking superficial tgfbr3 thigh undescribed variably
Tagcloud (Difference) ?		abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys picalm posits precede proof psen1 snps sorl1 sporadic triggers turn unlikely	alive bizarre borderline coded confined consultation cytokeratin desmin distinctive eighteen erg fascicular fibroblastic fibrous files fli histiocytoma incomplete nucleoli pleomorphism s100 soft spindled striking superficial tgfbr3 thigh undescribed variably
Tagcloud (Intersection) ?