PSEN2 and RAB11A

Number of citations of the paper that reports this interaction (PMID 10369872)
22

Data Source:
HPRD (in vivo, two hybrid)

		PSEN2	RAB11A
Gene Name		presenilin 2	RAB11A, member RAS oncogene family
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Kinetochore Nuclear Inner Membrane Mitochondrial Inner Membrane Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Cell Surface Membrane Apical Plasma Membrane Z Disc Axon Growth Cone Neuromuscular Junction Ciliary Rootlet Ciliary Basal Body Neuronal Cell Body Dendritic Shaft Protein Complex Membrane Raft Perinuclear Region Of Cytoplasm	Spindle Pole Mitochondrion Multivesicular Body Trans-Golgi Network Kinetochore Microtubule Cytosol Plasma Membrane Transport Vesicle Axon Cytoplasmic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Vesicle Cleavage Furrow Protein Complex Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Endopeptidase Activity Aspartic-type Endopeptidase Activity Protein Binding	GTPase Activity Protein Binding GTP Binding Microtubule Binding GDP Binding Syntaxin Binding Myosin V Binding
	Biological Process	Response To Hypoxia Cell Fate Specification Somitogenesis Negative Regulation Of Protein Phosphorylation Hair Follicle Development Hematopoietic Progenitor Cell Differentiation T Cell Activation Involved In Immune Response Myeloid Leukocyte Differentiation Membrane Protein Ectodomain Proteolysis Calcium Ion Transport Regulation Of Epidermal Growth Factor-activated Receptor Activity Notch Signaling Pathway Notch Receptor Processing Axon Guidance Memory Protein Transport Protein Processing Dorsal/ventral Neural Tube Patterning Embryonic Limb Morphogenesis Forebrain Development Membrane Protein Intracellular Domain Proteolysis Negative Regulation Of Protein Complex Assembly Negative Regulation Of Protein Binding Endoplasmic Reticulum Calcium Ion Homeostasis Intracellular Signal Transduction Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Synaptic Plasticity Lung Alveolus Development Thymus Development Brain Morphogenesis Beta-amyloid Metabolic Process Positive Regulation Of Coagulation T Cell Receptor Signaling Pathway Cardiac Muscle Contraction Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Cytokinesis Renal Water Homeostasis Water Transport Intracellular Protein Transport Exocytosis Organelle Organization Mitotic Metaphase Plate Congression Positive Regulation Of Epithelial Cell Migration Regulation Of Multivesicular Body Size Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle-mediated Transport Astral Microtubule Organization Neuron Projection Development Melanosome Transport Rab Protein Signal Transduction Multivesicular Body Assembly Positive Regulation Of Axon Extension Regulation Of Long-term Neuronal Synaptic Plasticity Plasma Membrane To Endosome Transport Regulation Of Protein Transport Establishment Of Vesicle Localization Transmembrane Transport Regulation Of Vesicle-mediated Transport Establishment Of Protein Localization To Organelle Protein Localization To Plasma Membrane Establishment Of Protein Localization To Membrane Mitotic Spindle Assembly Exosomal Secretion
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Regulated proteolysis of p75NTR Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by NOTCH p75 NTR receptor-mediated signalling Signaling by ERBB4 NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 NRIF signals cell death from the nucleus Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants	Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Vasopressin regulates renal water homeostasis via Aquaporins Translocation of GLUT4 to the plasma membrane VxPx cargo-targeting to cilium Assembly of the primary cilium Aquaporin-mediated transport Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS
Protein-Protein Interactions		58 interactors: AAMP ACTG1 APH1A APH1B APP BCL2L1 CAPN1 CASP1 CASP3 CASP6 CASP7 CASP8 CEP55 CFLAR CHKA CIB1 CSNK1A1 CSNK1D CSNK2A1 CTNNB1 CTNND2 DNAJB1 DOCK3 ECD EID1 ELAVL1 EVI5L EXOC6 FBXL12 FHL2 FLNA FLNB GCDH GFAP HPS1 ICAM5 IFIT3 IFIT5 KCNIP3 KCNIP4 LIPF MAST1 METTL2B MGEA5 NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PDCD4 PSENEN RAB11A RHEB RNF32 SPC24 SRI UBQLN1	28 interactors: CHMP1B CHMP3 DTNBP1 GDI2 IKBKG KAT2B MYO5A MYO5B OPTN PPP2R1A PPP2R1B PSEN1 PSEN2 PTGIR RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP4 RAB11FIP5 RAB3IL1 RABGGTB RCHY1 SEC13 STX4 TBXA2R TDP2 WDR44 YWHAG
Entrez ID		5664	8766
HPRD ID		02860	05715
Ensembl ID		ENSG00000143801	ENSG00000103769
Uniprot IDs		P49810	P62491
PDB IDs			1OIV 1OIW 1OIX 1YZK 2D7C 2GZD 2GZH 2HV8 4C4P
Enriched GO Terms of Interacting Partners?		Notch Receptor Processing Cell Death Death Apoptotic Process Programmed Cell Death Notch Signaling Pathway Regulation Of Apoptotic Process Cell Differentiation Regulation Of Cell Death Cell Development Positive Regulation Of Apoptotic Process Cell Morphogenesis Involved In Differentiation Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Anatomical Structure Morphogenesis Developmental Process Signal Transduction Protein Processing Cellular Response To Stimulus Signaling Execution Phase Of Apoptosis Response To Stimulus Multicellular Organismal Development System Development Cell Communication Anatomical Structure Development Membrane Protein Intracellular Domain Proteolysis Apoptotic Signaling Pathway Cell Morphogenesis Regulation Of Signaling Cell Surface Receptor Signaling Pathway Neuron Differentiation Regulation Of Cellular Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Proteolysis Intracellular Receptor Signaling Pathway Response To External Stimulus Cardiovascular System Development Anatomical Structure Formation Involved In Morphogenesis Angiogenesis Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Positive Regulation Of Peptidase Activity Membrane Protein Proteolysis Positive Regulation Of Catalytic Activity Generation Of Neurons Cell Cycle Negative Regulation Of Cell Death	Protein Transport Establishment Of Protein Localization Protein Localization Establishment Of Localization In Cell Cellular Localization Organelle Localization Vesicle-mediated Transport Establishment Of Organelle Localization Establishment Of Vesicle Localization Vesicle Localization Transport Exocytosis Regulation Of Signal Transduction Post-Golgi Vesicle-mediated Transport Membrane Organization Intracellular Transport Regulation Of Signaling Golgi Vesicle Transport Cell Death Death Insulin Secretion Secretion By Cell Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Synaptic Transmission Negative Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulated Secretory Pathway Regulation Of Synaptic Plasticity Regulation Of Body Fluid Levels Amyloid Precursor Protein Catabolic Process Cell-cell Signaling Peptide Hormone Secretion Secretion Peptide Secretion Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Phosphorylation Regulation Of Extrinsic Apoptotic Signaling Pathway Signaling Apoptotic Process Cell Cycle Cell Communication Negative Regulation Of Protein Kinase Activity Programmed Cell Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Cycle Process Negative Regulation Of Kinase Activity Hormone Secretion Regulation Of Protein Kinase Activity Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process
Tagcloud ?		abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys picalm posits precede proof psen1 snps sorl1 sporadic triggers turn unlikely	c2 compartments displays fip fip1 fip2 fip3 fip5 fips gtpases hela illumination integral lactc2 live membranes microscopy overlap overlapped overlapping pericentriolar phosphatidylserine probe ps recycling structured tubular
Tagcloud (Difference) ?		abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys picalm posits precede proof psen1 snps sorl1 sporadic triggers turn unlikely	c2 compartments displays fip fip1 fip2 fip3 fip5 fips gtpases hela illumination integral lactc2 live membranes microscopy overlap overlapped overlapping pericentriolar phosphatidylserine probe ps recycling structured tubular
Tagcloud (Intersection) ?