MGEA5 and OGT

Number of citations of the paper that reports this interaction (PMID 16505006)
34

Data Source:
BioGRID (pull down, pull down, enzymatic study)

		MGEA5	OGT
Gene Name		meningioma expressed antigen 5 (hyaluronidase)	O-linked N-acetylglucosamine (GlcNAc) transferase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Membrane	Histone Acetyltransferase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Microtubule Organizing Center Cytosol Plasma Membrane MLL5-L Complex
	Molecular Function	Histone Acetyltransferase Activity Hyalurononglucosaminidase Activity Beta-N-acetylglucosaminidase Activity	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Enzyme Activator Activity Acetylglucosaminyltransferase Activity Protein N-acetylglucosaminyltransferase Activity Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific) Protein O-GlcNAc Transferase Activity
	Biological Process	N-acetylglucosamine Metabolic Process Glycoprotein Catabolic Process Protein Deglycosylation Protein Targeting To Membrane Aging Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Cardiac Muscle Adaptation Histone Acetylation Positive Regulation Of Cell Killing Positive Regulation Of Insulin Secretion Positive Regulation Of Protein Complex Disassembly Positive Regulation Of Proteolysis DATP Metabolic Process Positive Regulation Of Glucose Import Response To Steroid Hormone Positive Regulation Of DNA Metabolic Process Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Protein Glycosylation Positive Regulation Of Growth Hormone Secretion Necrotic Cell Death	Regulation Of Glycolytic Process Chromatin Organization Protein O-linked Glycosylation Apoptotic Process Signal Transduction Response To Nutrient Positive Regulation Of Granulocyte Differentiation Negative Regulation Of Protein Ubiquitination Response To Insulin Circadian Regulation Of Gene Expression Regulation Of Rac Protein Signal Transduction Positive Regulation Of Catalytic Activity Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Proteolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone H3-K27 Methylation Cellular Response To Retinoic Acid Histone H3-K4 Trimethylation Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis
Pathways			Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: A2M C6 CDC37 CSNK2B DHX9 GSK3B MAST1 OGT PSEN2 RNF32	18 interactors: CSNK2A1 GSK3B HCFC1 MAPT MGEA5 NUP62 NUP62CL PHC3 PSG1 SIN3A SNAP91 SP1 SRF TAB1 TET2 TRAK1 TRAK2 YES1
Entrez ID		10724	8473
HPRD ID		04949	02222
Ensembl ID		ENSG00000198408	ENSG00000147162
Uniprot IDs		E9PGF9 O60502	O15294
PDB IDs		2YDQ	1W3B 3PE3 3PE4 3TAX 4AY5 4AY6 4GYW 4GYY 4GZ3 4GZ5 4GZ6
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Immune System Process Regulation Of Immune Response Axon Guidance Regulation Of Cellular Protein Metabolic Process Axonogenesis Circadian Rhythm Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Protein Metabolic Process Regulation Of Complement Activation Regulation Of Catalytic Activity Cell Morphogenesis Involved In Differentiation Regulation Of Binding Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Neuron Projection Development Regulation Of Humoral Immune Response Regulation Of Signal Transduction Rhythmic Process Cell Projection Morphogenesis Negative Regulation Of Protein Binding Cell Part Morphogenesis Negative Regulation Of Protein Metabolic Process Response To External Stimulus Cellular Response To Heat Neuron Development Intracellular Signal Transduction Regulation Of Signaling Regulation Of Acute Inflammatory Response Regulation Of Generation Of Precursor Metabolites And Energy Cell Morphogenesis Regulation Of Protein Phosphorylation Cell Differentiation Neuron Differentiation Cell Projection Organization Negative Regulation Of Binding Regulation Of Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Glucose Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Negative Regulation Of Complement Activation, Lectin Pathway Locomotion Establishment Of Cell Polarity Response To Heat	Positive Regulation Of Cell Growth Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Axon Extension Regulation Of Axon Extension Positive Regulation Of Growth Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Axonogenesis Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Protein Localization Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Component Organization Protein O-linked Glycosylation Protein Transport Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Establishment Of Protein Localization Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Aging Regulation Of RNA Metabolic Process Developmental Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Complex Assembly Regulation Of Cell Growth Regulation Of Cell Size Megakaryocyte Differentiation Cell Morphogenesis Involved In Differentiation Trophectodermal Cell Differentiation Histone Modification Anatomical Structure Morphogenesis Regulation Of Gene Expression Cellular Protein Modification Process Positive Regulation Of Developmental Growth Regulation Of Axonogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Response To Organic Substance Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Neuron Projection Development Positive Regulation Of Protein Complex Assembly Glycoprotein Metabolic Process Negative Regulation Of Protein Metabolic Process Blastocyst Formation Regulation Of Metabolic Process In Utero Embryonic Development
Tagcloud ?		alive bizarre borderline coded confined consultation cytokeratin desmin distinctive eighteen erg fascicular fibroblastic fibrous files fli histiocytoma incomplete nucleoli pleomorphism s100 soft spindled striking superficial tgfbr3 thigh undescribed variably	acetylglucosamine aggregates autophagic autophagosome autophagosomes autophagy caenorhabditis defective elegans endosomes facilitates flux glcnac glcnacylated glcnacylation integrates lysosomes mammalian mediates mutating nutrient promotes regulates reveals snap snare starvation transferase
Tagcloud (Difference) ?		alive bizarre borderline coded confined consultation cytokeratin desmin distinctive eighteen erg fascicular fibroblastic fibrous files fli histiocytoma incomplete nucleoli pleomorphism s100 soft spindled striking superficial tgfbr3 thigh undescribed variably	acetylglucosamine aggregates autophagic autophagosome autophagosomes autophagy caenorhabditis defective elegans endosomes facilitates flux glcnac glcnacylated glcnacylation integrates lysosomes mammalian mediates mutating nutrient promotes regulates reveals snap snare starvation transferase
Tagcloud (Intersection) ?