PRSS2 and SERPINA1

Number of citations of the paper that reports this interaction (PMID 2610933)
2

Data Source:
HPRD (in vitro)

		PRSS2	SERPINA1
Gene Name		protease, serine, 2 (trypsin 2)	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Golgi Apparatus Platelet Alpha Granule Lumen Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Glycoprotein Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Identical Protein Binding
	Biological Process	Proteolysis Digestion Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Collagen Catabolic Process Innate Immune Response Positive Regulation Of Cell Adhesion	Response To Hypoxia Platelet Degranulation Acute-phase Response Blood Coagulation Response To Lead Ion Negative Regulation Of Endopeptidase Activity Platelet Activation Response To Estradiol Response To Lipopolysaccharide Response To Methanol Response To Triglyceride Response To Cytokine Response To Chromate Negative Regulation Of Serine-type Endopeptidase Activity
Pathways		Collagen degradation Activation of Matrix Metalloproteinases Alpha-defensins Defensins Degradation of the extracellular matrix Innate Immune System	Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs			2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-Triol Beta-Mercaptoethanol
Diseases
GWAS		Pancreatitis ( 23143602)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Metabolite levels ( 22916037)
Protein-Protein Interactions		6 interactors: APP BPI CSN1S1 MMP9 SERPINA1 SLPI	26 interactors: ADAMTS4 ATP5C1 CELA1 CTRB1 CTSG DERL2 DERL3 ECHS1 ELANE GSDMB KLK13 KLK3 KLK5 LRP1 MMP11 MMP26 MMP7 PRSS1 PRSS2 PRSS3 PRTN3 RAP2A RCHY1 SDC2 SMAD4 VKORC1
Entrez ID		5645	5265
HPRD ID		03335	02463
Ensembl ID			ENSG00000197249
Uniprot IDs		A6XMV8 A6XMV9 P07478 Q5NV56	E9KL23 P01009
PDB IDs			1ATU 1D5S 1EZX 1HP7 1IZ2 1KCT 1OO8 1OPH 1PSI 1QLP 1QMB 2D26 2QUG 3CWL 3CWM 3DRM 3DRU 3NDD 3NDF 3NE4 3T1P 7API 8API 9API
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Binding Negative Regulation Of Endopeptidase Activity Regulation Of Binding Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Platelet Degranulation Response To Methanol Regulation Of Proteolysis Response To External Stimulus Response To Triglyceride Synaptic Growth At Neuromuscular Junction Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Collateral Sprouting In Absence Of Injury Negative Regulation Of Protein Metabolic Process Response To Chromate Positive Regulation Of Receptor Binding Platelet Activation Positive Regulation Of Keratinocyte Migration Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Serine-type Peptidase Activity Axon Choice Point Recognition Negative Regulation Of Macrophage Activation Neuron Remodeling Exocytosis Defense Response Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Interleukin-8 Production Axon Guidance Blood Coagulation Cellular Copper Ion Homeostasis Hemostasis Negative Regulation Of Cation Channel Activity Macrophage Differentiation Copper Ion Homeostasis Suckling Behavior Response To Bacterium Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Secretion By Cell Regulation Of Macrophage Activation Response To Lead Ion	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Protein Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Catabolic Process Cobalamin Metabolic Process Metabolic Process Response To Stress Vitamin Metabolic Process Digestion Killing By Host Of Symbiont Cells Defense Response Defense Response To Bacterium Tetrapyrrole Metabolic Process Water-soluble Vitamin Metabolic Process Protein Processing Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Negative Regulation Of Growth Of Symbiont In Host Regulation Of Growth Defense Response To Fungus Interaction With Symbiont Leukocyte Mediated Cytotoxicity ER-associated Ubiquitin-dependent Protein Catabolic Process Response To Fungus Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Beta-amyloid Clearance Response To Bacterium Small Molecule Metabolic Process Response To External Stimulus Negative Regulation Of Growth Negative Regulation Of Locomotion Response To Stimulus Factor XII Activation Nephrogenic Mesenchyme Morphogenesis Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Defense Response To Gram-positive Bacterium Regulation Of Dendrite Morphogenesis Regulation Of Cellular Component Organization Acute Inflammatory Response Phototransduction, Visible Light Wound Healing
Tagcloud ?		alternating appreciated blocks border boundary colocalizes dimethylation extending extends fails h3ac h3k4me2 h3k9me2 helps initiate insulator integrity interspersed ltr opening repressive retroviral segments speculate spread tcrb thymocytes transgene trypsinogen	abundantly adam10 amyloidophilic annular assemblies bace2 carries congo congophilia congophilic contributor dot generic iatrogenic join misfolding misfoldome pathophysiologic placentas preeclampsia prefibrillar presenilin proteoforms protofibrils prototype secretases shares supramolecular
Tagcloud (Difference) ?		alternating appreciated blocks border boundary colocalizes dimethylation extending extends fails h3ac h3k4me2 h3k9me2 helps initiate insulator integrity interspersed ltr opening repressive retroviral segments speculate spread tcrb thymocytes transgene trypsinogen	abundantly adam10 amyloidophilic annular assemblies bace2 carries congo congophilia congophilic contributor dot generic iatrogenic join misfolding misfoldome pathophysiologic placentas preeclampsia prefibrillar presenilin proteoforms protofibrils prototype secretases shares supramolecular
Tagcloud (Intersection) ?