SERPINA1 and DERL2

Number of citations of the paper that reports this interaction (PMID 16449194)
31

Data Source:
HPRD (in vivo)

		SERPINA1	DERL2
Gene Name		serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	derlin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Golgi Apparatus Platelet Alpha Granule Lumen Extracellular Vesicular Exosome	Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Glycoprotein Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Response To Hypoxia Platelet Degranulation Acute-phase Response Blood Coagulation Response To Lead Ion Negative Regulation Of Endopeptidase Activity Platelet Activation Response To Estradiol Response To Lipopolysaccharide Response To Methanol Response To Triglyceride Response To Cytokine Response To Chromate Negative Regulation Of Serine-type Endopeptidase Activity	Suckling Behavior Positive Regulation Of Cell Proliferation Positive Regulation Of Cell Growth ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation	Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease Signaling by Hedgehog
Drugs		2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-Triol Beta-Mercaptoethanol
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Metabolite levels ( 22916037)
Protein-Protein Interactions		26 interactors: ADAMTS4 ATP5C1 CELA1 CTRB1 CTSG DERL2 DERL3 ECHS1 ELANE GSDMB KLK13 KLK3 KLK5 LRP1 MMP11 MMP26 MMP7 PRSS1 PRSS2 PRSS3 PRTN3 RAP2A RCHY1 SDC2 SMAD4 VKORC1	5 interactors: KRTAP10-3 KRTAP10-7 KRTAP10-8 MFI2 SERPINA1
Entrez ID		5265	51009
HPRD ID		02463	16796
Ensembl ID		ENSG00000197249
Uniprot IDs		E9KL23 P01009	Q9GZP9
PDB IDs		1ATU 1D5S 1EZX 1HP7 1IZ2 1KCT 1OO8 1OPH 1PSI 1QLP 1QMB 2D26 2QUG 3CWL 3CWM 3DRM 3DRU 3NDD 3NDF 3NE4 3T1P 7API 8API 9API
Enriched GO Terms of Interacting Partners?		Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Protein Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Catabolic Process Cobalamin Metabolic Process Metabolic Process Response To Stress Vitamin Metabolic Process Digestion Killing By Host Of Symbiont Cells Defense Response Defense Response To Bacterium Tetrapyrrole Metabolic Process Water-soluble Vitamin Metabolic Process Protein Processing Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Negative Regulation Of Growth Of Symbiont In Host Regulation Of Growth Defense Response To Fungus Interaction With Symbiont Leukocyte Mediated Cytotoxicity ER-associated Ubiquitin-dependent Protein Catabolic Process Response To Fungus Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Beta-amyloid Clearance Response To Bacterium Small Molecule Metabolic Process Response To External Stimulus Negative Regulation Of Growth Negative Regulation Of Locomotion Response To Stimulus Factor XII Activation Nephrogenic Mesenchyme Morphogenesis Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Defense Response To Gram-positive Bacterium Regulation Of Dendrite Morphogenesis Regulation Of Cellular Component Organization Acute Inflammatory Response Phototransduction, Visible Light Wound Healing	Response To Methanol Response To Triglyceride Regulation Of Protein Processing Response To Chromate Positive Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Plasminogen Activation Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Serine-type Peptidase Activity Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Iron Ion Import Positive Regulation Of Protein Processing Response To Lead Ion Regulation Of Extracellular Matrix Disassembly Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Extracellular Matrix Organization Acute-phase Response Negative Regulation Of Cell-substrate Adhesion Platelet Degranulation Acute Inflammatory Response Iron Ion Transport Cellular Iron Ion Homeostasis Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Iron Ion Homeostasis Response To Estradiol Transition Metal Ion Homeostasis
Tagcloud ?		abundantly adam10 amyloidophilic annular assemblies bace2 carries congo congophilia congophilic contributor dot generic iatrogenic join misfolding misfoldome pathophysiologic placentas preeclampsia prefibrillar presenilin proteoforms protofibrils prototype secretases shares supramolecular	apparatus cdt cdts chimeras complementation cytolethal derl1 derlin dispensable distending ducreyi erad evasion exit exotoxins exploited haemophilus hrd1 intoxication p97 reaching retrograde retrotranslocation ricin toxins trafficked uncharacterized undescribed wr
Tagcloud (Difference) ?		abundantly adam10 amyloidophilic annular assemblies bace2 carries congo congophilia congophilic contributor dot generic iatrogenic join misfolding misfoldome pathophysiologic placentas preeclampsia prefibrillar presenilin proteoforms protofibrils prototype secretases shares supramolecular	apparatus cdt cdts chimeras complementation cytolethal derl1 derlin dispensable distending ducreyi erad evasion exit exotoxins exploited haemophilus hrd1 intoxication p97 reaching retrograde retrotranslocation ricin toxins trafficked uncharacterized undescribed wr
Tagcloud (Intersection) ?