SERPINA1 and PRSS3

Number of citations of the paper that reports this interaction (PMID 11057674)
144

Data Source:
HPRD (in vitro)

		SERPINA1	PRSS3
Gene Name		serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	protease, serine, 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Golgi Apparatus Platelet Alpha Granule Lumen Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Glycoprotein Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Identical Protein Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Serine-type Peptidase Activity
	Biological Process	Response To Hypoxia Platelet Degranulation Acute-phase Response Blood Coagulation Response To Lead Ion Negative Regulation Of Endopeptidase Activity Platelet Activation Response To Estradiol Response To Lipopolysaccharide Response To Methanol Response To Triglyceride Response To Cytokine Response To Chromate Negative Regulation Of Serine-type Endopeptidase Activity	Proteolysis Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Digestion Cobalamin Metabolic Process Zymogen Activation Endothelial Cell Migration Small Molecule Metabolic Process Innate Immune Response
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective AMN causes hereditary megaloblastic anemia 1 Defects in cobalamin (B12) metabolism Innate Immune System Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Alpha-defensins Defensins Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism
Drugs		2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-Triol Beta-Mercaptoethanol	4-(1,3,2-Dioxaborolan-2-Yloxy)Butan-1-Aminium 4-Hydroxybutan-1-Aminium 4-(Hydroxymethyl)Benzamidine Benzamidine [3-(1,3,2-Dioxaborolan-2-Yloxy)Propyl]Guanidine Guanidine-3-Propanol [4-(1,3,2-Dioxaborolan-2-Yloxy)Methyl]Benzamidine 1,3,2-Dioxaborolan-2-Ol
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Metabolite levels ( 22916037)
Protein-Protein Interactions		26 interactors: ADAMTS4 ATP5C1 CELA1 CTRB1 CTSG DERL2 DERL3 ECHS1 ELANE GSDMB KLK13 KLK3 KLK5 LRP1 MMP11 MMP26 MMP7 PRSS1 PRSS2 PRSS3 PRTN3 RAP2A RCHY1 SDC2 SMAD4 VKORC1	3 interactors: APP SERPINA1 TFPI
Entrez ID		5265	5646
HPRD ID		02463	06685
Ensembl ID		ENSG00000197249	ENSG00000010438
Uniprot IDs		E9KL23 P01009	A8CED3 P35030 Q6ISJ4 Q7Z5F4
PDB IDs		1ATU 1D5S 1EZX 1HP7 1IZ2 1KCT 1OO8 1OPH 1PSI 1QLP 1QMB 2D26 2QUG 3CWL 3CWM 3DRM 3DRU 3NDD 3NDF 3NE4 3T1P 7API 8API 9API	1H4W 2R9P 3L33 3L3T 3P92 3P95 4DG4
Enriched GO Terms of Interacting Partners?		Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Protein Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Catabolic Process Cobalamin Metabolic Process Metabolic Process Response To Stress Vitamin Metabolic Process Digestion Killing By Host Of Symbiont Cells Defense Response Defense Response To Bacterium Tetrapyrrole Metabolic Process Water-soluble Vitamin Metabolic Process Protein Processing Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Negative Regulation Of Growth Of Symbiont In Host Regulation Of Growth Defense Response To Fungus Interaction With Symbiont Leukocyte Mediated Cytotoxicity ER-associated Ubiquitin-dependent Protein Catabolic Process Response To Fungus Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Beta-amyloid Clearance Response To Bacterium Small Molecule Metabolic Process Response To External Stimulus Negative Regulation Of Growth Negative Regulation Of Locomotion Response To Stimulus Factor XII Activation Nephrogenic Mesenchyme Morphogenesis Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Defense Response To Gram-positive Bacterium Regulation Of Dendrite Morphogenesis Regulation Of Cellular Component Organization Acute Inflammatory Response Phototransduction, Visible Light Wound Healing	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Regulation Of Proteolysis Platelet Degranulation Response To Wounding Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Response To Methanol Platelet Activation Synaptic Growth At Neuromuscular Junction Response To Triglyceride Collateral Sprouting In Absence Of Injury Response To Chromate Blood Coagulation, Extrinsic Pathway Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Cellular Protein Metabolic Process Exocytosis Negative Regulation Of Serine-type Endopeptidase Activity Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Serine-type Peptidase Activity Axon Choice Point Recognition Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Neuron Remodeling Secretion By Cell Secretion Cellular Copper Ion Homeostasis Cell Activation Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Stress Response To Lead Ion Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior
Tagcloud ?		abundantly adam10 amyloidophilic annular assemblies bace2 carries congo congophilia congophilic contributor dot generic iatrogenic join misfolding misfoldome pathophysiologic placentas preeclampsia prefibrillar presenilin proteoforms protofibrils prototype secretases shares supramolecular	3d agar anchorage atypical bioluminescent cationic defines drive find invasive invasiveness isoform malignancy matrigel mediator mesotrypsin microarray modality neither orthotopic prostate prostatectomy proteolytic silencing soft suppress suppresses transwell trypsin
Tagcloud (Difference) ?		abundantly adam10 amyloidophilic annular assemblies bace2 carries congo congophilia congophilic contributor dot generic iatrogenic join misfolding misfoldome pathophysiologic placentas preeclampsia prefibrillar presenilin proteoforms protofibrils prototype secretases shares supramolecular	3d agar anchorage atypical bioluminescent cationic defines drive find invasive invasiveness isoform malignancy matrigel mediator mesotrypsin microarray modality neither orthotopic prostate prostatectomy proteolytic silencing soft suppress suppresses transwell trypsin
Tagcloud (Intersection) ?