PRMT8 and DCAF8

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		PRMT8	DCAF8
Gene Name		protein arginine methyltransferase 8	DDB1 and CUL4 associated factor 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane	Nucleus Cytoplasm Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Histone-arginine N-methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Identical Protein Binding Protein Homodimerization Activity Histone Methyltransferase Activity (H4-R3 Specific) Protein Heterodimerization Activity	Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Histone Methylation Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone Arginine Methylation Regulation Of Protein Binding Histone H4-R3 Methylation	Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS		HDL cholesterol ( 19060911)
Protein-Protein Interactions		13 interactors: CEP162 COIL DCAF8 GPATCH2L HIST1H4A OFCC1 PPARA PRMT1 SERBP1 SYNCRIP TAF15 VHL ZNF451	9 interactors: DDB1 GTPBP3 MDFI PRMT1 PRMT8 RAF1 RBPMS SUV39H1 THAP1
Entrez ID		56341	50717
HPRD ID		11029	18300
Ensembl ID		ENSG00000111218	ENSG00000132716
Uniprot IDs		Q59GT2 Q9NR22	B7Z8C9 Q5TAQ9
PDB IDs			3I8E
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Megakaryocyte Differentiation Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Gene Expression Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Glycolytic By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Negative Regulation Of Myeloid Cell Differentiation Posttranscriptional Regulation Of Gene Expression Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H4-K20 Demethylation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Chromatin Modification CRD-mediated MRNA Stabilization Transcription Initiation From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Myeloid Cell Differentiation Negative Regulation Of Receptor Biosynthetic Process Chromatin Organization Behavioral Response To Nicotine Enamel Mineralization Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Regulation Of Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Sequestering Of Triglyceride Negative Regulation Of Cholesterol Storage Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription DNA-templated Transcription, Initiation Negative Regulation Of Glycolytic Process DNA Replication-dependent Nucleosome Assembly Regulation Of RNA Biosynthetic Process Negative Regulation Of Appetite Tooth Mineralization Regulation Of RNA Metabolic Process Positive Regulation Of Fatty Acid Beta-oxidation Peptidyl-arginine N-methylation DNA Methylation On Cytosine Histone H4-R3 Methylation Cellular Protein Modification Process Response To Hypoxia Amelogenesis Negative Regulation Of Transcription Regulatory Region DNA Binding Chromatin Silencing At RDNA Negative Regulation Of Macrophage Derived Foam Cell Differentiation	Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone Modification Peptidyl-arginine N-methylation Histone Methylation Histone H4-R3 Methylation Histone Arginine Methylation Peptidyl-arginine Methylation Protein Methylation Chromatin Modification Chromatin Organization Chromosome Organization Death-inducing Signaling Complex Assembly Methylation Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Regulation Of Transcription, DNA-templated Regulation Of Protein Import Into Nucleus Negative Regulation Of Megakaryocyte Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Phosphorylation Regulation Of RNA Metabolic Process Regulation Of Protein Localization To Nucleus Histone H3-K9 Dimethylation UV-damage Excision Repair Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Viral Release From Host Cell MAPK Cascade Organelle Organization Positive Regulation Of Phosphorylation Cellular Protein Modification Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Protein Modification Process Regulation Of Binding Regulation Of Intracellular Protein Transport Histone H3-K9 Trimethylation Peptidyl-amino Acid Modification Activation Of Protein Kinase Activity Peptidyl-lysine Dimethylation Histone H2A Monoubiquitination Signal Transduction By Phosphorylation Response To Hypoxia Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of Metabolic Process Histone H2A Ubiquitination Regulation Of Protein Phosphorylation Chromatin Silencing At RDNA Regulation Of SMAD Protein Import Into Nucleus
Tagcloud ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt6 prmt7 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Difference) ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt6 prmt7 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Intersection) ?