PRMT8 and CEP162

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		PRMT8	CEP162
Gene Name		protein arginine methyltransferase 8	centrosomal protein 162kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane	Nucleoplasm Cytoplasm Centrosome Centriole Spindle Cytosol Axonemal Microtubule
	Molecular Function	Protein Binding Histone-arginine N-methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Identical Protein Binding Protein Homodimerization Activity Histone Methyltransferase Activity (H4-R3 Specific) Protein Heterodimerization Activity	Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Histone Methylation Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone Arginine Methylation Regulation Of Protein Binding Histone H4-R3 Methylation	Organelle Organization Cilium Assembly
Pathways			Organelle biogenesis and maintenance Assembly of the primary cilium Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS		HDL cholesterol ( 19060911)
Protein-Protein Interactions		13 interactors: CEP162 COIL DCAF8 GPATCH2L HIST1H4A OFCC1 PPARA PRMT1 SERBP1 SYNCRIP TAF15 VHL ZNF451	6 interactors: CPNE4 KDM1A PRMT1 PRMT8 SPP1 YEATS4
Entrez ID		56341	22832
HPRD ID		11029	10796
Ensembl ID		ENSG00000111218	ENSG00000135315
Uniprot IDs		Q59GT2 Q9NR22	Q5TB80
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Megakaryocyte Differentiation Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Gene Expression Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Glycolytic By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Negative Regulation Of Myeloid Cell Differentiation Posttranscriptional Regulation Of Gene Expression Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H4-K20 Demethylation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Chromatin Modification CRD-mediated MRNA Stabilization Transcription Initiation From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Myeloid Cell Differentiation Negative Regulation Of Receptor Biosynthetic Process Chromatin Organization Behavioral Response To Nicotine Enamel Mineralization Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Regulation Of Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Sequestering Of Triglyceride Negative Regulation Of Cholesterol Storage Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription DNA-templated Transcription, Initiation Negative Regulation Of Glycolytic Process DNA Replication-dependent Nucleosome Assembly Regulation Of RNA Biosynthetic Process Negative Regulation Of Appetite Tooth Mineralization Regulation Of RNA Metabolic Process Positive Regulation Of Fatty Acid Beta-oxidation Peptidyl-arginine N-methylation DNA Methylation On Cytosine Histone H4-R3 Methylation Cellular Protein Modification Process Response To Hypoxia Amelogenesis Negative Regulation Of Transcription Regulatory Region DNA Binding Chromatin Silencing At RDNA Negative Regulation Of Macrophage Derived Foam Cell Differentiation	Histone Modification Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Chromatin Modification Peptidyl-arginine N-methylation Histone H4-R3 Methylation Chromatin Organization Histone Arginine Methylation Peptidyl-arginine Methylation Regulation Of Megakaryocyte Differentiation Regulation Of Hematopoietic Progenitor Cell Differentiation Chromosome Organization Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Primitive Erythrocyte Differentiation Histone Methylation Regulation Of Protein Binding Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Protein Methylation Regulation Of Myeloid Cell Differentiation Peptidyl-amino Acid Modification Negative Regulation Of Megakaryocyte Differentiation Regulation Of Binding Negative Regulation Of Collateral Sprouting Organelle Organization Cellular Protein Modification Process Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Negative Regulation Of Axon Regeneration Histone H3-K4 Demethylation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Hormone Biosynthetic Process Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Differentiation Methylation Histone H2A Acetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Bone Resorption Granulocyte Differentiation Regulation Of Axon Regeneration Negative Regulation Of Histone Methylation In Utero Embryonic Development Positive Regulation Of Erythrocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Histone H3-K4 Methylation
Tagcloud ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt6 prmt7 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Difference) ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt6 prmt7 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Intersection) ?